구강점막질환환자에서 치과재료를 이용한 첩포시험 결과에 대한 고찰
Dental materials in patients with oral mucosal disease based on the results of patch test study
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
다양한 원인에 의해 발생하는 구강점막질환은 점막의 변형을 동반하기도 하고 점막의 변형없이 증상만을호소하는 경우도 있다. 점막에 병변이 나타나는 경우그 원인요소는 세균, 바이러스, 진균, 타액분비저하,음식물 등의 직접적인 요소도 있지만 복용하는 약물,면역반응, 혈액이상, 전신질환, 정신장애, 등의 간접적인 요소도 분명히 작용한다고 알려져 있다1, 2). 이중 치과재료는 구강내에 오랜시간 존재하게 되고특히 금속의 경우 마모, 부식, 용해반응으로 인하여나타나는 이온형태의 물질이 체내에 흡수되어 면역반응을 일으키거나, 구강점막에 대한 직접적이고 반복적인 접촉으로 구강내 지연형 접촉성 과민반응을 발생시킬 수 있다3, 4). 이들 점막반응은 발적부터 궤양까지다양한 형태를 보이지만 특징적인 징후가 관찰되지는않아 정확한 감별진단은 어려운 경우가 많다5, 6).
Abstract
The aim of this study was to investigate the frequency of positive patch test reaction to dental materials in patients with oral mucosal diseases. Epicutaneous patch test was performed in 110 patients with oral mucosal diseases; 41 patients with oral lichen planus(OLP), 44 patients with burning mouth syndrome(BMS), 25 patients with other oral mucosal diseases including recurrent aphthous ulcer and mucous membrane pemphigoid. The obtained results were as follows: Oral gold restorations were most common in patents with oral mucosal diseases and porcelain fused metal crown, implant appeared in the order. 33 of 110 patients did not appear skin reactions (negative, 30%) and 77 patients (positive, 70%) had skin reactions including redness, rash, blisters. Dental materials causing positive reaction to patch test were mainly as gold-sodium-thiosulfate (26.7%), nickel sulfate(Ni) (22.7%), cobalt chloride(Co) (14.7%), palladium chloride(Pd) (11.9%), potassium dichromate (10.7%) in order, respectively. In conclusion, old metal restorations could be the cause of oral mucosal diseases and epicutaneous patch test could be used as a tool to improve the oral conditions.
참고문헌 (31)
- Sapp JP, "Contemporary oral and maxillofacial pathology", pp.245~248 (1997), Clarinda Co
- Sharma A, "Lichen planus: An update and review", Cutis, 90, pp.17~23 (2012)
- McParland H, "Oral lichenoid contact lesions to mercury and dental amalgam-a review", J Biomed Biotechnol, 2012, pp.589~569 (2012)
- Ahlgren C, "The necessity of a test reading after 1week to detect late positive patch test reactions in patients with oral lichen lesions" (2013), Clin Oral Investig
- Alanko K, "Oral mucosal diseases investigated by patch testing with a dental screening series", Contact Dermatitis, 34, pp.263~267 (1996)
- Holmstrup P., "Reactions of the oral mucosa related to silver amalgam: A review", J Oral Pathol Med, 20, pp.1~7 (1991)
- Vass G, "Epicutaneous patch test--a new diagnostic option to prevent the rejection of silicone-covered cochlear implants in children", Int J Pediatr Otorhinolaryngol, 77, pp.1635~1638 (2013)
- Cobos-Fuentes MJ, "Oral lichenoid lesions related to contact with dental materials: A literature review", Med Oral Patol Oral Cir Bucal, 14, pp.e514~e520 (2009)
- Lindmaier A, "Problems with dental prosthesis and dental filling materials: Results of epicutaneous tests, consequences and follow-up", Z Hautkr, 64, pp.24~30 (1989)
- Koch P, "Oral lesions and symptoms related to metals used in dental restorations: A clinical, allergological, and histologic study", J Am Acad Dermatol, 41, pp.422~430 (1999)
- Dal Sacco D, "Contact allergy in the burning mouth syndrome: A retrospective study on 38 patients", Acta Derm Venereol, 85, pp.63~64 (2005)
- Bakula A, "Contact allergy in the mouth: Diversity of clinical presentations and diagnosis of common allergens relevant to dental practice", Acta Clin Croat, 50, pp.553~561 (2011)
- Polanco I., "Celiac disease", J Pediatr Gastroenterol Nutr, 47(Suppl 1), pp.S3~S6 (2008)
- 민숙진, "첩포시험을 이용한 구강점막질환 환자의 접촉성 과민반응에 대한 평가", Journal of Oral Medicine and Pain, 27(2), pp.159~172 (2002), 대한안면통증∙구강내과학회
- Levi L, "Allergic reactions associated with metal alloys in porcelain-fused-tometal fixed prosthodontic devices-A systematic review", Quintessence Int, 43, pp.871~877 (2012)
- Rasanen L, "Contact allergy to gold in dental patients", Br J Dermatol, 134, pp.673~677 (1996)
- . Moller H., "Dental gold alloys and contact allergy", Contact Dermatitis, 47, pp.63~66 (2002)
- Stenman E, "Hypersensitivity reactions to dental materials in a referred group of patients", Scand J Dent Res, 97, pp.76~83 (1989)
- Marino R, "Burning mouth syndrome: The role of contact hypersensitivity", Oral Dis, 15, pp.255~258 (2009)
- Grushka M, "Burning mouth syndrome", Am Fam Physician, 65, pp.615~620 (2002)
- Issa Y, "Healing of oral lichenoid lesions after replacing amalgam restorations: A systematic review", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 98, pp.553~565 (2004)
- Dunsche A, "Oral lichenoid reactions associated with amalgam: Improvement after amalgam removal", Br J Dermatol, 148, pp.70~76 (2003)
- Mehulic M, "Expression of contact allergy in undergoing prosthodontic therapy patients with oral diseases", Minerva Stomatol, 54, pp.303~309 (2005)
- Brandao GA, "Evaluation of ionic degradation and slot corrosion of metallic brackets by the action of different dentifrices", Dental Press J Orthod, 18, pp.86~93 (2013)
- Mutlu-Sagesen L, "Ion release from metal-ceramic alloys in three different media", Dent Mater J, 30, pp.598~610 (2011)
- Kim YJ, "Effects of smoking on trace metal levels in saliva", Oral Dis, 16, pp.823~830 (2010)
- Niki Y, "Screening for symptomatic metal sensitivity: A prospective study of 92 patients undergoing total knee arthroplasty", Biomaterials, 26, pp.1019~1026 (2005)
- Cadosch D, "Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening--current concepts", J Biomed Mater Res A, 91, pp.1252~1262 (2009)
- Urban RM, "Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement", J Bone Joint Surg Am, 82, pp.457~476 (2000)
- Virgili A, "Burning mouth syndrome: The role of contact hypersensitivity", Acta Derm Venereol, 76, pp.488~490 (1996)
- Hietanen J, "No evidence of hypersensitivity to dental restorative metals in oral lichen planus", Scand J Dent Res, 95, pp.320~327 (1987)