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골 대사 약물 복용 환자의 MRONJ 위험 인자로의 Implants

Dental Implants as Risk Factors for MRONJ in Patients Taking Bone Modifying Agents

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초록

As the age of patients requiring implant treatments increases, the number of patients taking more than one type of medicine due to underlying diseases increases. In particular, bone modifying agents such as bisphosphonate bring rare but potentially fatal osteonecrosis of the jaw (ONJ), so careful attention is needed before dental treatment. For patients receiving these medications, the outcome of implants and the incidence of implant related ONJ are still unclear, causing clinicians to hesitate to treat them. Therefore, in this article, we would like to discuss the dental implants as a risk factor for the occurrence of ONJ and discuss what clinicians should consider in implant treatment for patients taking bone modifying agents by reviewing previous literatures.

Abstract

As the age of patients requiring implant treatments increases, the number of patients taking more than one type of medicine due to underlying diseases increases. In particular, bone modifying agents such as bisphosphonate bring rare but potentially fatal osteonecrosis of the jaw (ONJ), so careful attention is needed before dental treatment. For patients receiving these medications, the outcome of implants and the incidence of implant related ONJ are still unclear, causing clinicians to hesitate to treat them. Therefore, in this article, we would like to discuss the dental implants as a risk factor for the occurrence of ONJ and discuss what clinicians should consider in implant treatment for patients taking bone modifying agents by reviewing previous literatures.

참고문헌 (57)

  1. Ruggiero SL, "American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update", J Oral Maxillofac Surg, 72(10), pp.1938~1956 (2014)
  2. Chadha GK, "Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy : a systematic review", J Oral Implantol, 39(4), pp.510~520 (2013)
  3. S hannon J, "Bisphosphonates and osteonecrosis of the jaw", J Am Geriatr Soc, 59(12), pp.2350~2355 (2011)
  4. Al-Sabbagh M, "Effect of Bisphosphonate and Age on Implant Failure as Determined by Patient-Reported Outcomes", J Oral Implantol, 41(6), pp.e287~291 (2015)
  5. Wood J, "Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid", J Pharmacol Exp Ther, 302(3), pp.1055~1061 (2002)
  6. Otto S, "Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases", Cancer Treat Rev, 69, pp.177~187 (2018)
  7. Khosla S, "Bisphosphonate-associated osteonecrosis of the jaw : report of a task force of the American Society for Bone and Mineral Research", J Bone Miner Res, 22(10), pp.1479~1491 (2007)
  8. Watts NB, "Invasive Oral Procedures and Events in Postmenopausal Women With Osteoporosis Treated With Denosumab for Up to 10 Years", J Clin Endocrinol Metab, 104(6), pp.2443~2452 (2019)
  9. Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws AAoO, "American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws", J Oral Maxillofac Surg, 65(3), pp.369~376 (2007)
  10. Lazarovici TS, "Bisphosphonate-related osteonecrosis of the jaw associated with dental implants", J Oral Maxillofac Surg, 68(4), pp.790~796 (2010)
  11. Limones A, "zoledronic acid : A systematic review and meta-analysis", Med Oral Patol Oral Cir Bucal, 25(3), pp.e326~e336 (2020)
  12. Hanley DA, "Denosumab : mechanism of action and clinical outcomes", Int J Clin Pract, 66(12), pp.1139~1146 (2012)
  13. Aghaloo TL, "Osteonecrosis of the jaw in a patient on Denosumab", J Oral Maxillofac Surg, 68(5), pp.959~963 (2010)
  14. Poxleitner P, "The Prevention of Medication-related Osteonecrosis of the Jaw", Dtsch Arztebl Int, 114(5), pp.63~69 (2017)
  15. Saad F, "Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases", Ann Oncol, 23(5), pp.1341~1347 (2012)
  16. Roelofs AJ, "Molecular mechanisms of action of bisphosphonates : current status", Clin Cancer Res, 12(20 Pt 2), pp.6222s~6230s (2006)
  17. Madrid C, "What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review", Clin Oral Implants Res, 20(Suppl 4), pp.87~95 (2009)
  18. Esposito M, "Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology", Eur J Oral Sci, 106(1), pp.527~551 (1998)
  19. Giovannacci I, "Medication-Related Osteonecrosis of the Jaw Around Dental Implants: Implant Surgery-Triggered or Implant Presence-Triggered Osteonecrosis?", J Craniofac Surg, 27(3), pp.697~701 (2016)
  20. Minsk L, "Dental implant outcomes in postmenopausal women undergoing hormone replacement", Compend Contin Educ Dent, 19(9), pp.859~862 (1998)
  21. Yajima N, "Influence of Bisphosphonates on Implant Failure Rates and Characteristics of Postmenopausal Woman Mandibular Jawbone", J Oral Implantol, 43(5), pp.345~349 (2017)
  22. Cabrales-Salgado RJ, "Mechanical Properties of the Mandible in Postmenopausal Women Under Aledronate Treatment", J Int Acad Periodontol, 22(4), pp.231~235 (2020)
  23. Fliefel R, "Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw(BRONJ)with characterization of patients : a systematic review", Int J Oral Maxillofac Surg, 44(5), pp.568~585 (2015)
  24. Sher J, "Dental Implant Placement in Patients with a History of Medications Related to Osteonecrosis of the Jaws: A Systematic Review", J Oral Implantol (2020)
  25. Marx RE, "Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment", J Oral Maxillofac Surg, 65(12), pp.2397~2410 (2007)
  26. Jacobsen C, "Osteopathology induced by bisphosphonates and dental implants : clinical observations", Clin Oral Investig, 17(1), pp.167~175 (2013)
  27. Marx RE, "Bisphosphonate induced exposed bone (osteonecrosis", osteopetrosis) of the jaws:risk factors, recognition, prevention, and treatment, 2005, pp.63(11), 1567~1575
  28. Aljohani S, "What is the effect of anti-resorptive drugs(ARDs)on the development of medication-related osteonecrosis of the jaw(MRONJ)in osteoporosis patients : A systematic review", J Craniomaxillofac Surg, 45(9), pp.1493~1502 (2017)
  29. Otto S, "Tooth extraction in patients receiving oral or intravenous bisphosphonate administration:A trigger for BRONJ development?", J Craniomaxillofac Surg, 43(6), pp.847~854 (2015)
  30. Kos M, "Bisphosphonates enhance bacterial adhesion and biofilm formation on bone hydroxyapatite", J Craniomaxillofac Surg, 43(6), pp.863~869 (2015)
  31. Khan AA, "Diagnosis and management of osteonecrosis of the jaw : a systematic review and international consensus", J Bone Miner Res, 30(1), pp.3~23 (2015)
  32. AlDhalaan NA, "Medication-related Osteonecrosis of the Jaw : A Review", Cureus, 12(2), pp.e6944~ (2020)
  33. Stavropoulos A, "The effect of antiresorptive drugs on implant therapy : Systematic review and metaanalysis", Clin Oral Implants Res, 29(Suppl 18), pp.54~92 (2018)
  34. Martin DC, "Characteristics of implant failures in patients with a history of oral bisphosphonate therapy", J Oral Maxillofac Surg, 68(3), pp.508~514 (2010)
  35. Tallarico M, "Dental implants treatment outcomes in patient under active therapy with alendronate : 3-year follow-up results of a multicenter prospective observational study", Clin Oral Implants Res, 27(8), pp.943~949 (2016)
  36. Pogrel MA, "Previously successful dental implants can fail when patients commence anti-resorptive therapy-a case series", Int J Oral Maxillofac Surg, 47(2), pp.220~222 (2018)
  37. Troeltzsch M, "Clinical features of periimplant medication-related osteonecrosis of the jaw: Is there an association to peri-implantitis?", J Craniomaxillofac Surg, 44(12), pp.1945~1951 (2016)
  38. Pichardo SEC, "Dental implants as risk factors for patients with medication-related osteonecrosis of the jaws(MRONJ)", Br J Oral Maxillofac Surg, 58(7), pp.771~776 (2020)
  39. Kwon TG, "Osteonecrosis associated with dental implants in patients undergoing bisphosphonate treatment", Clin Oral Implants Res, 25(5), pp.632~640 (2014)
  40. Hoefert S, "Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw : a possible pathogenetic model of symptomatic and nonsymptomatic osteonecrosis of the jaw based on scanning electron microscopy findings", Clin Oral Investig, 14(3), pp.271~284 (2010)
  41. Bedogni A, "Oral bisphosphonate-associated osteonecrosis of the jaw after implant surgery : a case report and literature review", J Oral Maxillofac Surg, 68(7), pp.1662~1666 (2010)
  42. Marx RE, "A decade of bisphosphonate bone complications : what it has taught us about bone physiology", Int J Oral Maxillofac Implants, 29(2), pp.e247~258 (2014)
  43. Grant BT, "Outcomes of placing dental implants in patients taking oral bisphosphonates : a review of 115 cases", J Oral Maxillofac Surg, 66(2), pp.223~230 (2008)
  44. Nisi M, "Risk factors influencing BRONJ staging in patients receiving intravenous bisphosphonates : a multivariate analysis", Int J Oral Maxillofac Surg, 44(5), pp.586~591 (2015)
  45. Otto S, "Bisphosphonate-related osteonecrosis of the jaws - characteristics, risk factors, clinical features, localization and impact on oncological treatment", J Craniomaxillofac Surg, 40(4), pp.303~309 (2012)
  46. Fehm T, "Bisphosphonate-induced osteonecrosis of the jaw(ONJ) : Incidence and risk factors in patients with breast cancer and gynecological malignancies", Gynecol Oncol, 112(3), pp.605~609 (2009)
  47. Papadakis I, "Success rate and safety of dental implantology in patients treated with antiresorptive medication: A systematic review", J Oral Implantol (2020)
  48. Mozzati M, "Failure risk estimates after dental implants placement associated with plasma rich in growth factor-Endoret in osteoporotic women under bisphosphonate therapy", J Craniofac Surg, 26(3), pp.749~755 (2015)
  49. de-Freitas NR, "Bisphosphonate treatment and dental implants : A systematic review", Med Oral Patol Oral Cir Bucal, 21(5), pp.e644~651 (2016)
  50. Kasai T, "The prognosis for dental implants placed in patients taking oral bisphosphonates", J Calif Dent Assoc, 37(1), pp.39~42 (2009)
  51. Tallarico M, "Clinical and radiological outcomes of 1-versus 2-stage implant placement : 1-year results of a randomised clinical trial", Eur J Oral Implantol, 4(1), pp.13~20 (2011)
  52. American Dental Association Council on Scientific A, "Dental management of patients receiving oral bisphosphonate therapy: expert panel recommendations", J Am Dent Assoc, 137(8), pp.1144~1150 (2006)
  53. Yip JK, "Association between oral bisphosphonate use and dental implant failure among middle-aged women", J Clin Periodontol, 39(4), pp.408~414 (2012)
  54. Markiewicz MR, "Bisphosphonate-associated osteonecrosis of the jaws : a review of current knowledge", J Am Dent Assoc, 136(12), pp.1669~1674 (2005)
  55. Kumar MN, "Survival of dental implants in bisphosphonate users versus non-users : a systematic review", Eur J Prosthodont Restor Dent, 20(4), pp.159~162 (2012)
  56. Sim Ie W, "Declining Incidence of Medication-Related Osteonecrosis of the Jaw in Patients With Cancer", J Clin Endocrinol Metab, 100(10), pp.3887~3893 (2015)
  57. Kim JY, "Effects of anti-resorptive drugs on implant survival and peri-implantitis in patients with existing osseointegrated dental implants : a retrospective cohort study", Osteoporos Int, 31(9), pp.1749~1758 (2020)

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