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Lactobacillus rhamnosus GG Reverses Insulin Resistance but Does Not Block Its Onset in Diet-Induced Obese Mice

김보배|현창기|박근영
한국미생물·생명공학회 (The Korean Society For Microbiology And Biotechnology)|2015|Journal of Microbiology and Biotechnology|제25권 제5호|pp. 753-757|DOI 10.4014/jmb.1409.09016

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키워드

adiponectininsulin resistancedysbiosisLactobacillus rhamnosus GGadiposity
주제분류생물학

초록

Recently, Lactobacillus rhamnosus GG (LGG) was shown to exert insulin-sensitizing and adiposity-reducing effects in high-fat (HF) diet-fed mice. In the present study, we observed that the effects were correlated with the extent of dysbiosis induced by HF diet feeding before LGG administration. LGG-treated mice were protected from HF diet-induced adiposity and/ or insulin resistance when LGG was treated after, not along with, HF diet feeding. Results indicate that, under HF dietary condition, supplemented LGG reverses insulin resistance, but does not block its onset.

Abstract

Recently, Lactobacillus rhamnosus GG (LGG) was shown to exert insulin-sensitizing and adiposity-reducing effects in high-fat (HF) diet-fed mice. In the present study, we observed that the effects were correlated with the extent of dysbiosis induced by HF diet feeding before LGG administration. LGG-treated mice were protected from HF diet-induced adiposity and/ or insulin resistance when LGG was treated after, not along with, HF diet feeding. Results indicate that, under HF dietary condition, supplemented LGG reverses insulin resistance, but does not block its onset.

참고문헌 (18)

  1. Andreasen AS, "Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects", Br. J. Nutr, 104, pp.1831~1838 (2010)
  2. Aronsson L, "Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4)", PLoS One, 5, pp.e13087~ (2010)
  3. Cani PD, "Interplay between obesity and associated metabolic disorders: new insights into the gut", Curr. Opin. Pharmacol, 9, pp.737~743 (2009)
  4. Cao H., "Adipocytokines in obesity and metabolic disease", J. Endocrinol, 220, pp.T47~T59 (2014)
  5. Clemente JC, "The impact of the gut microbiota on human health: an integrative view", Cell, 148, pp.1258~1270 (2012)
  6. Delzenne NM, "Targeting gut microbiota in obesity: effects of prebiotics and probiotics", Nat. Rev. Endocrinol, 7, pp.639~646 (2011)
  7. Honda K, "Anti-diabetic effects of lactic acid bacteria in normal and type 2 diabetic mice", J. Clin. Biochem. Nutr, 51, pp.96~101 (2012)
  8. Kahn SE, "Mechanisms linking obesity to insulin resistance and type 2 diabetes", Nature, 444, pp.840~846 (2006)
  9. Kim SW, "Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production", Biochem. Biophys. Res. Commun, 431, pp.258~263 (2013)
  10. Kondo S, "Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity", Biosci. Biotechnol. Biochem, 74, pp.1656~1661 (2010)
  11. Lee HY, "Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice", Biochim. Biophys. Acta, 1761, pp.736~744 (2006)
  12. Ley RE, "Obesity alters gut microbial ecology", Proc. Natl. Acad. Sci. USA, 102, pp.11070~11075 (2005)
  13. Matsuzaki T, "Antidiabetic effects of an oral administration of Lactobacillus casei in a non-insulin-dependent diabetes mellitus (NIDDM)model using KK-Ay mice", Endocr. J, 44, pp.357~365 (1997)
  14. Olefsky JM, "Macrophages, inflammation, and insulin resistance", Annu. Rev. Physiol, 72, pp.219~246 (2010)
  15. Quigley EM, "Gut microbiota and the role of probiotics in therapy", Curr. Opin. Pharmacol, 11, pp.593~603 (2011)
  16. Tabuchi M, "Antidiabetic Effect of Lactobacillus GG in streptozotocin-induced diabetic rats", Biosci. Biotechnol. Biochem, 67, pp.1421~1424 (2003)
  17. Takemura N, "Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet", Exp. Biol. Med, 235, pp.849~856 (2010)
  18. Yadav H, "Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats", Nutrition, 23, pp.62~68 (2007)

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