Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity.
Abstract
Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity.
참고문헌 (32)
- Arner P, "Dynamics of human adipose lipid turnover in health and metabolic disease", Nature, 478, pp.110~113 (2011)
- Ridaura VK, "Gut microbiota from twins discordant for obesity modulate metabolism in mice", Science, 341, pp.1241214~ (2013)
- Turnbaugh PJ, "An obesity-associated gut microbiome with increased capacity for energy harvest", Nature, 444, pp.1027~1031 (2006)
- Velagapudi VR, "The gut microbiota modulates host energy and lipid metabolism in mice", J. Lipid Res, 51, pp.1101~1112 (2010)
- Ellulu MS, "Obesity and inflammation : the linking mechanism and the complications", Arch. Med. Sci, 13, pp.851~863 (2017)
- Makki K, "Adipose tissue in obesity-related inflammation and insulin resistance : cells, cytokines, and chemokines", ISRN Inflamm, 2013, pp.139239~ (2013)
- Cani PD, "Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity", Gut Microbes, 3, pp.279~288 (2012)
- Boulange CL, "Impact of the gut microbiota on inflammation, obesity, and metabolic disease", Genome Med, 8, pp.42~ (2016)
- George Kerry R, "Benefaction of probiotics for human health : a review", J. Food Drug Anal, 26, pp.927~939 (2018)
- He MQ, "Gut microbiota as a potential target of metabolic syndrome : the role of probiotics and prebiotics", Cell. Biosci, 7, pp.54~ (2017)
- Yoo SR, "Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and suppress diet-induced obesity", Obesity (Silver Spring), 21, pp.2571~2578 (2013)
- Li H, "Probiotic mixture of Lactobacillus plantarum strains improves lipid metabolism and gut microbiota structure in high fat diet-fed mice", Front. Microbiol, 11, pp.512~ (2020)
- Jeong SH, "Microbial succession and metabolite changes during long-term storage of Kimchi", J. Food Sci, 78, pp.M763~M769 (2013)
- Kwon MS, "Lactobacillus sakei WIKIM30 ameliorates atopic dermatitis-like skin lesions by inducing regulatory T cells and altering gut microbiota structure in mice", Front. Immunol, 9, pp.1905~ (2018)
- 홍이판, "Different Immune Regulatory Potential of Lactobacillus plantarum and Lactobacillus sakei Isolated from Kimchi", Journal of Microbiology and Biotechnology, 24(12), pp.1629~1635 (2014), 한국미생물·생명공학회[DOI]
- Lim SM, "Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression", Nutr. Res, 36, pp.337~348 (2016)
- Won SM, "Isolation of lactic acid bacteria from kimchi and screening of Lactobacillus sakei ADM14with anti-adipogenic effect and potential probiotic properties", LWT Food Sci. Technol, 126, pp.109296~ (2020)
- Lee J, "Mixture of two Lactobacillus plantarum strains modulates the gut microbiota structure and regulatory T cell response in diet-induced obese mice", Mol. Nutr. Food Res, 62, pp.e1800329~ (2018)
- Sanchez de Medina F, "Intestinal inflammation and mucosal barrier function", Inflamm. Bowel Dis, 20, pp.2394~2404 (2014)
- Meddings J, "The significance of the gut barrier in disease", Gut, 57, pp.438~440 (2008)
- Morrison DJ, "Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism", Gut Microbes, 7, pp.189~200 (2016)
- Bessesen DH, "Progress and challenges in anti-obesity pharmacotherapy", Lancet Diabetes. Endocrinol, 6, pp.237~248 (2018)
- Kadooka Y, "Regulation of abdominal adiposity by probiotics(Lactobacillus gasseri SBT2055)in adults with obese tendencies in a randomized controlled trial", Eur. J. Clin. Nutr, 64, pp.636~643 (2010)
- Cani PD, "The role of the gut microbiota in energy metabolism and metabolic disease", Curr. Pharm. Des, 15, pp.1546~1558 (2009)
- Tilg H, "Gut microbiome, obesity, and metabolic dysfunction", J. Clin. Invest, 121, pp.2126~2132 (2011)
- Reddy JK, "Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation", Am. J. Physiol. Gastrointest. Liver Physiol, 290, pp.G852~G858 (2006)
- Choe SS, "Adipose tissue remodeling : its role in energy metabolism and metabolic disorders", Front. Endocrinol, 7, pp.30~ (2016)
- Ahmad R, "Obesity-induces organ and tissue specific tight junction restructuring and barrier deregulation by claudin switching", Sci. Rep, 7, pp.5125~ (2017)
- Cani PD, "Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability", Gut, 58, pp.1091~1103 (2009)
- Chaithanya Chelakkot, "Mechanisms regulating intestinal barrier integrity and its pathological implications", Experimental and Molecular Medicine, 50, pp.1~9 (2018), 생화학분자생물학회
- Priyadarshini M, "Role of short chain fatty acid receptors in intestinal physiology and pathophysiology", Compr. Physiol, 8, pp.1091~1115 (2018)
- Tang Y, "G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer", Int. J. Cancer, 128, pp.847~856 (2011)
