Effect of Differential Thermal Drying Conditions on the Immunomodulatory Function of Ginger
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Thermal drying is a common process used in the food industry for the modification of agricultural products. However, while various studies have investigated the alteration in physiochemical properties and chemical composition after drying, research focusing on the relationship between different dehydration conditions and bioactivity is scarce. In the current study, we prepared dried ginger under nine different conditions by varying the processing time and temperature and compared their immunomodulatory effects. Interestingly, depending on the drying condition, there were significant differences in the immunestimulating activity of the dried ginger samples. Gingers processed at 50oC 1h displayed the strongest activation of macrophages measured by TNF-α and IL-6 levels, whereas, freezedried or 70oC- and 90oC-dried ginger showed little effect. Similar results were recapitulated in primary bone marrow-derived macrophages, further confirming that different dehydration conditions can cause significant differences in the immune-stimulating activity of ginger. Induction of ERK, p38, and JNK signaling was found to be the major underlying molecular mechanism responsible for the immunomodulatory effect of ginger. These results highlight the potential to improve the bioactivity of functional foods by selectively controlling processing conditions
Abstract
Thermal drying is a common process used in the food industry for the modification of agricultural products. However, while various studies have investigated the alteration in physiochemical properties and chemical composition after drying, research focusing on the relationship between different dehydration conditions and bioactivity is scarce. In the current study, we prepared dried ginger under nine different conditions by varying the processing time and temperature and compared their immunomodulatory effects. Interestingly, depending on the drying condition, there were significant differences in the immunestimulating activity of the dried ginger samples. Gingers processed at 50oC 1h displayed the strongest activation of macrophages measured by TNF-α and IL-6 levels, whereas, freezedried or 70oC- and 90oC-dried ginger showed little effect. Similar results were recapitulated in primary bone marrow-derived macrophages, further confirming that different dehydration conditions can cause significant differences in the immune-stimulating activity of ginger. Induction of ERK, p38, and JNK signaling was found to be the major underlying molecular mechanism responsible for the immunomodulatory effect of ginger. These results highlight the potential to improve the bioactivity of functional foods by selectively controlling processing conditions
참고문헌 (44)
- Escudero-Lopez B, "Effect of thermal processing on the profile of bioactive compounds and antioxidant capacity of fermented orange juice", Int. J. Food. Sci. Nutr, 67, pp.779~788 (2016)
- Jorge A, "Evaluation of the chemical composition and colour in long-life tomatoes(Lycopersicon esculentum Mill)dehydrated by combined drying methods", Int. J. Food Sci. Technol, 49, pp.2001~2007 (2014)
- Sharma KD, "Chemical composition, functional properties and processing of carrot—a review", J. Food Sci. Technol, 49, pp.22~32 (2012)
- Price KR, "Composition and content of flavonol glycosides in broccoli florets(Brassica olearacea)and their fate during cooking", J. Sci. Food Agric, 77, pp.468~472 (1998)
- Byun S, "Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization", Mol. Nutr. Food Res, 60, pp.1068~1078 (2016)
- Van Eylen D, "Kinetics of the stability of broccoli (Brassica oleracea Cv, Italica) myrosinase and isothiocyanates in broccoli juice during pressure", temperature treatments, 2007, pp.55, 2163~2170
- Ali BH, "Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research", Food Chem. Toxicol, 46, pp.409~420 (2008)
- Byun S, "Identification of a Dual Inhibitor of Janus Kinase 2(JAK2)and p70 Ribosomal S6 Kinase1(S6K1)Pathways", J. Biol. Chem, 290, pp.23553~23562 (2015)
- Abuajah CI, "Functional components and medicinal properties of food : a review", J. Food Sci. Technol, 52, pp.2522~2529 (2015)
- Ferreira SS, "Structure–function relationships of immunostimulatory polysaccharides : A review", Carbohydr. Polym, 132, pp.378~396 (2015)
- Wang C-Z, "Cancer chemoprevention effects of ginger and its active constituents : potential for new drug discovery", Am. J. Chin. Med, 43, pp.1351~1363 (2015)
- Azam F, "Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation", Drug Des., Dev. Ther, 8, pp.2045~2059 (2014)
- Backon J, "Ginger in preventing nausea and vomiting of pregnancy: a caveat due to its thromboxane synthetase activity and effect on testosterone binding", Eur. J. Obstet. Gynecol. Reprod. Biol, 42, pp.163~164 (1991)
- Butt MS, "Ginger and its health claims : molecular aspects", Crit. Rev. Food Sci. Nutr, 51, pp.383~393 (2011)
- Jafarzadeh A, "Therapeutic potentials of ginger for treatment of Multiple sclerosis : A review with emphasis on its immunomodulatory, anti-inflammatory and anti-oxidative properties", J. Neuroimmunol, 324, pp.54~75 (2018)
- Li Y, "Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review", Evid. Based Complement. Alternat. Med, 2012, pp.516870~ (2012)
- Nicoll R, "Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease?", Int, J. Cardiol, 131, pp.408~409 (2009)
- Shukla Y, "Cancer preventive properties of ginger: a brief review", Food Chem. Toxicol, 45, pp.683~690 (2007)
- Zeng GF, "Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats", Rejuvenation Res, 16, pp.124~133 (2013)
- Zheng W, "Antioxidant activity and phenolic compounds in selected herbs", J. Agric. Food Chem, 49, pp.5165~5170 (2001)
- Shakya SR, "Medicinal uses of ginger (Zingiber officinale Roscoe) improves growth and enhances immunity in aquaculture", Int. J. Chem. Stud, 3, pp.83~87 (2015)
- Dhama K, "Multiple beneficial applications and modes of action of herbs in poultry health and productionA review", Int. J. Phamacol, 11, pp.152~176 (2015)
- Bartley JP, "Effects of drying on flavour compounds in Australian-grown ginger (Zingiber officinale)", J. Sci. Food Agric, 80, pp.209~215 (2000)
- An K, "Comparison of different drying methods on Chinese ginger(Zingiber officinale Roscoe) : changes in volatiles, chemical profile, antioxidant properties, and microstructure", Food Chem, 197, pp.1292~1300 (2016)
- Gümüşay ÖA, "Drying effects on the antioxidant properties of tomatoes and ginger", Food Chem, 173, pp.156~162 (2015)
- Lapenna A, "Perivascular macrophages in health and disease", Nat. Rev. Immunol, 18, pp.689~702 (2018)
- Shapouri-Moghaddam A, "Macrophage plasticity, polarization, and function in health and disease", J. Cell. Physiol, 233, pp.6425~6440 (2018)
- Bedoret D, "Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice", J. Clin. Invest, 119, pp.3723~3738 (2009)
- Wang M, "Characterization of the microenvironment of the testis that shapes the phenotype and function of testicular macrophages", J. Immunol, 198, pp.4327~4340 (2017)
- Schwandt T, "Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis", EMBO J, 31, pp.201~213 (2012)
- Ruparelia N, "Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans", Eur. Heart J, 36, pp.1923~1934 (2015)
- Tsujioka H, "Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction", J. Am. Coll. Cardiol, 54, pp.130~138 (2009)
- Kurihara T, "Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor", J. Exp. Med, 186, pp.1757~1762 (1997)
- Nimmerjahn A, "Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo", Science, 308, pp.1314~1318 (2005)
- Genard G, "Reprogramming of tumor-associated macrophages with anticancer therapies : radiotherapy versus chemo-and immunotherapies", Front. Immunol, 8, pp.828~ (2017)
- Sangwan A, "Nutritional composition of ginger powder prepared using various drying methods", J. Food Sci. Technol, 51, pp.2260~2262 (2014)
- Ghasemzadeh A, "Formation of 6-, 8- and 10-shogaol in ginger through application of different drying methods: altered antioxidant and antimicrobial activity", Molecules, 23(pii), pp.E1646~ (2018)
- Martinez FO, "Macrophage activation and polarization", Front. Biosci, 13, pp.453~461 (2008)
- Wynn TA, "Macrophage biology in development, homeostasis and disease", Nature, 496, pp.445~455 (2013)
- Mosser DM, "Exploring the full spectrum of macrophage activation", Nat. Rev. Immunol, 8, pp.958~969 (2008)
- Rao KM, "MAP kinase activation in macrophages", J. Leukocyte. Biol, 69, pp.3~10 (2001)
- Lloberas J, "Mitogen-activated protein kinases and mitogen kinase phosphatase 1 : a critical interplay in macrophage biology", Front. Mol. Biosci, 3, pp.28~ (2016)
- Campbell J, "A novel mechanism for TNF-alpha regulation by p38 MAPK : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis", J. Immunol, 173, pp.6928~6937 (2004)
- 정문웅, "Heat-induced conversion of gingerols to shogaols in ginger as affected by heat type (dry or moist heat), sample type (fresh or dried), temperature and time", Food Science and Biotechnology, 27(3), pp.687~693 (2018), 한국식품과학회[DOI]