본문 바로가기
KERD
논문KCI 등재

RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity

장재혁|장민아|고성균|Ahn Jong Seog|Jang Jun-Pil|Nogawa Toshihiko|Takahashi Shunji|Osada Hiroyuki
한국미생물·생명공학회 (The Korean Society For Microbiology And Biotechnology)|2022.03|Journal of Microbiology and Biotechnology|제32권 제3호|pp. 302-306|DOI 10.4014/jmb.2110.10039

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

Streptomyces sp.Oxindolestructural elucidationanti-angiogenic activity
주제분류생물학

초록

A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and Highresolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.

Abstract

A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and Highresolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.

참고문헌 (18)

  1. Newman DJ, "Natural products as sources of new drugs over the nearly four decades from 01", 1981 to 09, J. Nat. Prod, pp.2020 (2019), 83[DOI]
  2. Fenical W, "Developing a new resource for drug discovery : marine actinomycete bacteria", Nat. Chem. Biol, 2, pp.666~673 (2006)
  3. Saito S, "Discovery of"heat shock metabolites"produced by thermotolerant actinomycetes in high-temperature culture", J. Antibiot, 73, pp.203~210 (2020)
  4. Gil Soo Kim, "Jejucarbazoles A–C, carbazole glycosides with indoleamine 2,3-dioxygenase 1 inhibitory activity from Streptomyces sp. KCB15JA151", RSC Advances, 11(32), pp.19805~19812 (2021), Royal Society of Chemistry (RSC)[DOI]
  5. Jun-Pil Jang, "Aturanosides A and B, glycosylated anthraquinones with antiangiogenic activity from a soil-derived Streptomyces species", Journal of Natural Products, 81(9), pp.2004~2009 (2018), American Chemical Society (ACS)[DOI]
  6. Jun-Pil Jang, "Pentaminomycins A and B, hydroxyarginine-containing cyclic pentapeptides from Streptomyces sp. RK88-1441", Journal of Natural Products, 81(4), pp.806~810 (2018), American Chemical Society (ACS)[DOI]
  7. Jang J-P, "Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum", J. Nat. Prod, 80, pp.134~140 (2017)
  8. Carmeliet P, "Angiogenesis in health and disease", Nat. Med, 6, pp.653~660 (2003)
  9. Lee J, "Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells", Carcinogenesis, 11, pp.1991~1998 (2010)
  10. Jing Zhang, "Antimetastatic effect of prodigiosin through inhibition of tumor invasion", Biochemical Pharmacology, 69(3), pp.407~414 (2005), Elsevier BV[DOI]
  11. KOICHI NAKAE, "Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities", The Journal of Antibiotics, 53(10), pp.1130~1136 (2000), Japan Antibiotics Research Association[DOI]
  12. Jun-Pil Jang, "RK-270A−C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270", The Journal of Antibiotics, 68(4), pp.293~295 (2014), Springer Science and Business Media LLC[DOI]
  13. Zheng D, "Structure elucidation of four prenylindole derivatives from Streptomyces sp. isolated from Ailuropoda melanoleuca feces", Magn. Reson. Chem, 51, pp.188~191 (2013)
  14. Bryan BA, "What tangled webs they weave : Rho-GTPase control of angiogenesis", Cell. Mol. Life. Sci, 64, pp.2053~2065 (2007)
  15. Rini BI, "Vascular endothelial growth factor-targeted therapy in renal cell carcinoma : current status and future directions", Clin. Cancer Res, 13, pp.1098~1106 (2007)
  16. Ng EWM, "Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration", Can. J. Ophthalmol, 40, pp.352~368 (2005)
  17. Olsson AK, "VEGF receptor signalling-in control of vascular function", Nat. Rev. Mol. Cell. Biol, 7, pp.359~371 (2006)
  18. Lamalice L, "Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2", p38, 2004, pp.23, 434~445

관련 논문AI추천

Hygrolansamycins A-D, O-Heterocyclic Macrolides from Streptomyces sp. KCB17JA11고성균, 장재혁, 홍영수, 황방연, Heo Kyung Taek, Jang Jun-Pil, Lee Byeongsan, Lee Hyeok-Won, Oh Tae Hoon한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2022 · 제32권 제10호MMPP is a novel VEGFR2 inhibitor that suppresses angiogenesis via VEGFR2/AKT/ERK/NF-κB pathway신하연, 윤도영, Hee Pom Lee, Hyo-Min Park, Jae-Young Park, Jin Tae Hong, Na-Yeon Kim, Uijin Kim생화학분자생물학회 · BMB Reports2024 · 제57권 제5호Sarcotrine G, a New Derivative Isolated from a Marine Sponge Sarcotragus Species노정래, 박명길, 황병수, Su Young Park한국자기공명학회 · Journal of the Korean Magnetic Resonance Society2008 · 제12권 제1호A new derivative of phorbaketals isolated from a Marine Sponge Phorbas species노정래, 황병수, Cao Yang한국자기공명학회 · Journal of the Korean Magnetic Resonance Society2011 · 제15권 제2호Dieckol Suppresses CoCl2-induced Angiogenesis in Endothelial Cells김영목, 박선주, 장인승, 전유진, 정승현한국수산과학회 · Fisheries and Aquatic Sciences2014 · 제17권 제3호A new sesterterpenoid showing anti-inflammatory effect from the Marine Sponge Haliclona species이경, 노정래한국자기공명학회 · Journal of the Korean Magnetic Resonance Society2015 · 제19권 제1호

이 간행물의 다른 논문 (14건)

Strategies to Mitigate Enteric Methane Emissions from Ruminant Animals김선원, 권문혁, Sanjorjo Rey Anthony, Tseten Tenzinpp. 269-277An Engineered Outer Membrane-Defective Escherichia coli Secreting Protective Antigens against Streptococcus suis via the Twin- Arginine Translocation Pathway as a VaccineLi Shaowen, Liu Yuying, Zhang Yongqing, Chen Xiabing, Zhou Rui, Huang Qi, Li Lu, Li Wenyu, Yin Fan, Bu Zixuanpp. 278-286Electron Transfer to Hydroxylase through Component Interactions in Soluble Methane MonooxygenaseHwang Yunha, Lee Chaemin, 강현구, 이승재pp. 287-293Appropriate Soil Heat Treatment Promotes Growth and Disease Suppression of Panax notoginseng by Interfering with the Bacterial CommunityZhu Shu-Sheng, Yang Min, Yuan Ye, Li Ying-Bin, Zhang Zhi-Ping, Huang Hui-Chuan, Mei Xin-Yue, Du Fen, Liu Yi-Xiangpp. 294-301Functional Characterization of khadi Yeasts Isolates for Selection of Starter CulturesMotlhanka Koketso, Garcia-Aloy Mar, Lebani Kebaneilwe, Zhou Nervepp. 307-316
원문 보기