폐경 유무에 따른 대사 증후군의 구성 요소와 유병률의 차이
Differences of Prevalence and Components of Metabolic Syndrome according to Menopausal Status
2
조회
0
다운로드
24
인용
0
참고문헌
키워드
초록
연구목적: 폐경은 대사적, 내분비적인 변화를 가져오며 이러한 변화는 대사증후군의 유병률에도 영향을 미칠 가능성이 있을 것으로 생각된다. 이에 건강검진을 위해 방문한 여성을 대상으로 폐경 유무에 따른 대사증후군의유병률과 구성요소의 차이를 조사하였다. 연구재료 및 방법: 2006년 1월부터 2010년 12월까지 부산대학교 병원에서 건강 검진을 시행한 여성에 대하여 신체계측, 혈압, 혈액 검사 수치를 후향적으로 의무기록을 토대로 조사하여, 대사증후군 유무에 따른 차이와 폐경유무와 연령에 따른 대사증후군 구성요소와 발생의 차이를 조사하였다. 결과: 폐경 전 여성에서 대사증후군의 유병률은 8.69%였으며, 폐경 후 여성에서는 21.85%였다. 대사증후군을 가진 여성에서 정상군에 비해 높은 체중과 비만도, 높은 콜레스테롤 수치를 보였다. 대사증후군의 구성요소로는낮은 고밀도 콜레스테롤이 가장 높은 비율을 보였으며, 고혈압과 고혈당은 폐경 후 여성에서 유의하게 높은 비율을 보였다. 대사증후군의 발생에 대해 폐경과 연령군을 세분화하여 회귀분석을 시행한 결과 폐경과는 무관하였으며, 연령의 증가에 따라 대사증후군의 발생이 유의하게 증가하는 것으로 밝혀졌다. 결론: 대사증후군의 발생에 폐경은 제한적인 영향을 미치는 것으로 보이며 연령의 증가가 더 중요할 것으로 생각된다. 그러나, 수술적 폐경, 호르몬 치료를 시행 중인 폐경여성과 대사증후군의 관련성 등에 대해서는 세분화된 대상을 통한 추가적인 연구가 필요할 것으로 사료된다.
Abstract
Objectives: Metabolic and endocrinologic alterations is developed at menopausal transition of women and these alterations can have an effect on prevalence of metabolic syndrome. Therefore, we evaluated the prevalence of metabolic syndrome and differences of components as menopausal status of women who visited our health screening clinic. Methods: We surveyed body sizes, blood pressures and other several blood tests from January 2006 to December 2010 in Pusan National University Hospital by retrospectively reviewing medical records. These results were compared as presence of metabolic syndrome and menopausal status. Differences of the components of metabolic syndrome as the menopausal status and occurrences of metabolic syndrome as the age and the menopausal status are investigated. Results: In premenopausal and postmenopausal women, the prevalence of metabolic syndrome were 8.69% and 21.85%,respectively. More body weight, high body mass index and cholesterol were checked in women who have metabolic syndrome irrespective of menopausal status. Low high density lipoprotein was most prominent component of metabolic syndrome irrespective of menopausal status. Hypertension and high blood sugar were showed meaningful proportions in postmenopausal women. The prevalence of metabolic syndrome was unrelated to the menopausal status by regressively analyze, but meaningfully increased related to aging. Conclusion: Menopausal alterations restrictively effect on occurrence of metabolic syndrome and aging is more effect on it. But more detailed and additional studies are needed about determining the relation of metabolic syndrome in women who surgically menopaused and receiving hormone therapy.
참고문헌 (22)
- Flegal KM, "Prevalence and trends in obesity among US adults, 1999-2000", JAMA, 288, pp.1723~1727 (2002)
- Calle EE, "Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults", N Engl J Med, 348, pp.1625~1638 (2003)
- Bray GA, "Medical consequences of obesity", J Clin Endocrinol Metab, 89, pp.2583~2589 (2004)
- Ford ES, "Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey", JAMA, 287, pp.356~359 (2002)
- von Muhlen D, "Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study", Osteoporos Int, 18, pp.1337~1344 (2007)
- Najarian RM, "Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: the Framingham Offspring Study", Arch Intern Med, 166, pp.106~111 (2006)
- Lovejoy JC, "The menopause and obesity", Prim Care, 30, pp.317~325 (2003)
- Carr MC, "The emergence of the metabolic syndrome with menopause", J Clin Endocrinol Metab, 88, pp.2404~2411 (2003)
- National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report", Circulation, 106, pp.3143~3421 (2002)
- Li Z, "Effects of gender and menopausal status on plasma lipoprotein subspecies and particle sizes", J Lipid Res, 37, pp.1886~1896 (1996)
- Lindheim SR, "Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test", J Soc Gynecol Investig, 1, pp.150~154 (1994)
- Jeon SK, "Relationship between metabolic syndrome and bone mineral density in middle-aged women", J Korean Soc Menopause, 16, pp.142~147 (2010)
- 김희만, "The effect of menopause on the metabolic syndrome among Korean women", DIABETES CARE, 30(3), pp.701~706, AMER DIABETES ASSOC
- Cho GJ, "The relationship between reproductive factors and metabolic syndrome in Korean postmenopausal women: Korea National Health and Nutrition Survey 2005", Menopause, 16, pp.998~1003 (2009)
- Roos A, "Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects", J Clin Endocrinol Metab, 92, pp.491~496 (2007)
- Royer M, "The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III): prevalence of the metabolic syndrome in postmenopausal Latin American women", Climacteric, 10, pp.164~170 (2007)
- Deibert P, "Effect of a weight loss intervention on anthropometric measures and metabolic risk factors in preversus postmenopausal women", Nutr J, 6, pp.31~ (2007)
- Duntas LH, "Thyroid disease and lipids", Thyroid, 12, pp.287~293 (2002)
- Figueiredo Neto JA, "Metabolic syndrome and menopause: cross-sectional study in gynecology clinic", Arq Bras Cardiol, 95, pp.339~345 (2010)
- Oh JY, "Prevalence and factor analysis of metabolic syndrome in an urban Korean population", DIABETES CARE, 27, pp.2027~2032, AMER DIABETES ASSOC
- Novgorodtseva TP, "Composition of fatty acids in plasma and erythrocytes and eicosanoids level in patients with metabolic syndrome", Lipids Health Dis, 10, pp.82~ (2011)
- Pandey S, "Menopause and metabolic syndrome: A study of 498 urban women from western India", J Midlife Health, 1, pp.63~69 (2010)