Effect of Foeniculum Vulgare (Fennel) on Sleep Quality of Menopausal Women: A Double-blinded, Randomized Placebo-controlled Trial
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Objectives: Aim of present study was designed to investigate the soporific effect of fennel among menopausal women.Methods: The present double–blinded and placebo-controlled trial examined the fennel effect on Pittsburgh Sleep Quality Index (PSQI). Total score and relevant 7 components, including sleep duration, sleep latency, use of sleeping medication, subjective sleep quality, sleep disturbances, daytime dysfunction and habitual sleep efficiency among 50 menopausal women compared to control group within a 12-week follow-up. Results: The patients in both groups reported no certain side effects and all subjects completed the study. The mean actual sleep duration was 5 hours and 66 minutes. Intergroup comparison revealed no statistically significant differences in the mean total PSQI score (P = 0.439), subjective sleep quality (P = 0.826), habitual sleep efficiency (P = 0.127), sleep disturbances (P = 0.130), use of sleeping medication (P = 0.52) and daytime dysfunction (P = 0.439). A tendency toward significant between 2 groups was seen concerning the sleep duration (P = 0.059). Intergroup comparison showed significantly borderline levels (P = 0.059). Conclusions: The treatment of 12 weeks with fennel caused a slight effect that did not reach to significant. These findings should be considered cautiously because of small sample size, short-term follow-up and subjective measure of sleep quality.
Abstract
Objectives: Aim of present study was designed to investigate the soporific effect of fennel among menopausal women.Methods: The present double–blinded and placebo-controlled trial examined the fennel effect on Pittsburgh Sleep Quality Index (PSQI). Total score and relevant 7 components, including sleep duration, sleep latency, use of sleeping medication, subjective sleep quality, sleep disturbances, daytime dysfunction and habitual sleep efficiency among 50 menopausal women compared to control group within a 12-week follow-up. Results: The patients in both groups reported no certain side effects and all subjects completed the study. The mean actual sleep duration was 5 hours and 66 minutes. Intergroup comparison revealed no statistically significant differences in the mean total PSQI score (P = 0.439), subjective sleep quality (P = 0.826), habitual sleep efficiency (P = 0.127), sleep disturbances (P = 0.130), use of sleeping medication (P = 0.52) and daytime dysfunction (P = 0.439). A tendency toward significant between 2 groups was seen concerning the sleep duration (P = 0.059). Intergroup comparison showed significantly borderline levels (P = 0.059). Conclusions: The treatment of 12 weeks with fennel caused a slight effect that did not reach to significant. These findings should be considered cautiously because of small sample size, short-term follow-up and subjective measure of sleep quality.
참고문헌 (18)
- Taavoni S, "Postmenopausal women’s quality of sleep and its related factors", J Midlife Health, 6, pp.21~25 (2015)
- Freedman RR, "Sleep disturbance in menopause", Menopause, 14, pp.826~829 (2007)
- Fatemeh Abdi, "Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action", 대한폐경학회지, 22(2), pp.62~64 (2016), 대한폐경학회
- Pelin Zivdir, "Effect of Feelings of Guilt and Shame on Life Quality of Women in Menopause", 대한폐경학회지, 23(1), pp.5~14 (2017), 대한폐경학회
- Sarti CD, "Hormone therapy and sleep quality in women around menopause", Menopause, 12, pp.545~551 (2005)
- Timur S, "Effects of sleep disturbance on the quality of life of Turkish menopausal women : a populationbased study", Maturitas, 64, pp.177~181 (2009)
- Listos J, "Adenosinergic system is involved in development of diazepam tolerance in mice", Pharmacol Biochem Behav, 94, pp.510~515 (2010)
- Hattori A, "Short-duration ACTH therapy for cryptogenic West syndrome with better outcome", Pediatr Neurol, 35, pp.415~418 (2006)
- Taavoni S, "Effect of valerian on sleep quality in postmenopausal women : a randomized placebo-controlled clinical trial", Menopause, 18, pp.951~955 (2011)
- Kooti W, "Therapeutic and pharmacological potential of Foeniculum vulgare Mill : A review", J Herb Med Pharmacol, 4, pp.1~9 (2015)
- Shirazi M, "Comparison of melissa with citalopram and placebo in treatment of sleep disorders in menopausal women : Clinical trial", Tehran Univ Med J, 74, pp.562~568 (2016)
- Asgari P, "The effect of Glycyrriza glabra on quality of life in postmenopausal women", Complement Med J Fac Nurs Midwifery, 5, pp.1146~1154 (2015)
- Talbott S, "Effect of MonaVie Rest™on sleep duration and sleep quality in moderately stressed subjects (647.23)", FASEB J, 28, pp.647.23~ (2014)
- Abolfazl Fattah, "Effect of Phytoestrogen on Depression and Anxiety in Menopausal Women: A Systematic Review", 대한폐경학회지, 23(3), pp.160~165 (2017), 대한폐경학회
- Jamison JR., "Phytoestrogens: An HRT alternative?", J Complement Med, 1, pp.62~65 (2002)
- Ghazanfarpour M, "Effect of Foeniculum vulgare (fennel) on symptoms of depression and anxiety in postmenopausal women: a double-blind randomised controlled trial", J Obstet Gynaecol, 38, pp.121~126 (2018)
- Yaralizadeh M, "Effect of Foeniculum vulgare(fennel)vaginal cream on vaginal atrophy in postmenopausal women : A double-blind randomized placebo-controlled trial", Maturitas, 84, pp.75~80 (2016)
- Najar S, "Effect of fennel vaginal cream on dysparonia and sexual satisfaction among postmenopausal women : A double-blind randomized controlled trial", Iran J Obstet Gynecol Infertil, 18, pp.8~16 (2015)