The Effect of Short-term Treatment with Fennel on Bone Density in Postmenopausal Women: A Randomized Controlled Trial
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Objectives: The goal of this study is to assess the effect of fennel on bone density. Methods: This was a double-blind, randomized, placebo-controlled trial, which studied sixty eligible postmenopausal women, who were randomly assigned to fennel and placebo groups. Then, the dual energy X-ray absorptiometry was utilized to measure bone mineral density (BMD) and bone mineral content (BMC) of the spine, femoral neck, intertrochanter, and trochanter at the baseline and after three-month follow-up. Results: The mean BMD and BMC at lumbar spine (P = 0.14, P = 0.504), total hip femoral (P = 0.427, P = 0.471), trochanter (P = 0.075, P = 0.07), intertrochanter, (P = 0.864, P = 0.932) and femoral neck (P = 0.439, P = 0.641) was not significantly different between the fennel and placebo groups. Conclusions: The results of this study did not approve the effect of fennel on bone density in post-menopausal women. However, to gain deeper insights, further studies with longer durations and larger sample sizes are recommended. (J Menopausal Med 2017;23:124-130)
Abstract
Objectives: The goal of this study is to assess the effect of fennel on bone density. Methods: This was a double-blind, randomized, placebo-controlled trial, which studied sixty eligible postmenopausal women, who were randomly assigned to fennel and placebo groups. Then, the dual energy X-ray absorptiometry was utilized to measure bone mineral density (BMD) and bone mineral content (BMC) of the spine, femoral neck, intertrochanter, and trochanter at the baseline and after three-month follow-up. Results: The mean BMD and BMC at lumbar spine (P = 0.14, P = 0.504), total hip femoral (P = 0.427, P = 0.471), trochanter (P = 0.075, P = 0.07), intertrochanter, (P = 0.864, P = 0.932) and femoral neck (P = 0.439, P = 0.641) was not significantly different between the fennel and placebo groups. Conclusions: The results of this study did not approve the effect of fennel on bone density in post-menopausal women. However, to gain deeper insights, further studies with longer durations and larger sample sizes are recommended. (J Menopausal Med 2017;23:124-130)
참고문헌 (27)
- Prestwood KM, "Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women: a randomized controlled trial", JAMA, 290, pp.1042~1048 (2003)
- Anitha D, "Comparison of Buckling Ratio and Finite Element Analysis of Femoral Necks in Post-menopausal Women", 대한폐경학회지, 20(2), pp.52~56 (2014), 대한폐경학회
- Atkinson C, "The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebocontrolled trial", Am J Clin Nutr, 79, pp.326~333 (2004)
- Boyack M, "Efficacy of raloxifene for treatment of menopause: a systematic review", J Am Acad Nurse Pract, 14, pp.150~165 (2002)
- Kreijkamp-Kaspers S, "Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial", JAMA, 292, pp.65~74 (2004)
- Colacurci N, "Effects of soy isoflavones on menopausal neurovegetative symptoms", Minerva Ginecol, 56, pp.407~412 (2004)
- Ghazanfarpour M, "Topical administration of isoflavones for treatment of vaginal symptoms in postmenopausal women: A systematic review of randomised controlled trials", J Obstet Gynaecol, 35, pp.783~787 (2015)
- Ghazanfarpour M, "The application of soy isoflavones for subjective symptoms and objective signs of vaginal atrophy in menopause: A systematic review of randomised controlled trials", J Obstet Gynaecol, 36, pp.160~171 (2016)
- Ghazanfarpour M, "Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis", J Obstet Gynaecol, 36, pp.301~311 (2016)
- Balk JL, "A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium", J Soc Gynecol Investig, 9, pp.238~242 (2002)
- Garga C, "Chemical composition, therapeutic potential and perspectives of Foeniculum vulgare", Pharmacogn Rev, 3, pp.346~352 (2009)
- Sadrefozalayi S, "Effect of the aqueous extract of Foeniculum vulgare (fennel) on the kidney in experimental PCOS female rats", Avicenna J Phytomed, 4, pp.110~117 (2014)
- Rahimi R, "Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy", Chin J Integr Med, 19, pp.73~79 (2013)
- Mahmoudi Z, "Effects of Foeniculum vulgare ethanol extract on osteogenesis in human mecenchymal stem cells", Avicenna J Phytomed, 3, pp.135~142 (2013)
- Kim TH, "Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss", Int J Mol Med, 29, pp.1053~1059 (2012)
- Emel Kiyak Caglayan, "Evaluation of Bone Density Measurement in Type 2 Diabetic Postmenopausal Women with Hypertension and Hyperlipidemia", 대한폐경학회지, 21(1), pp.36~40 (2015), 대한폐경학회
- Chi XX, "The effects of soy isoflavone on bone density in north region of climacteric Chinese women", J Clin Biochem Nutr, 53, pp.102~107 (2013)
- Huang HY, "One-year soy isoflavone supplementation prevents early postmenopausal bone loss but without a dose-dependent effect", J Nutr Biochem, 17, pp.509~517 (2006)
- Kenny AM, "Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial", Am J Clin Nutr, 90, pp.234~242 (2009)
- Ye YB, "Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : a single-blind randomized, placebo-controlled trial", Eur J Nutr, 45, pp.327~334 (2006)
- Brink E, "Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study", Am J Clin Nutr, 87, pp.761~770 (2008)
- Clifton-Bligh PB, "Red clover isoflavones enriched with formononetin lower serum LDL cholesterol-a randomized, double-blind, placebo-controlled study", Eur J Clin Nutr, 69, pp.134~142 (2015)
- Thorup AC, "Intake of novel red clover supplementation for 12 weeks improves bone status in healthy menopausal women", Evid Based Complement Alternat Med, 2015, pp.689138~ (2015)
- Abdi F, "Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials", Climacteric, 19, pp.535~545 (2016)
- Tai TY, "The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study", Osteoporos Int, 23, pp.1571~1580 (2012)
- Wong WW, "Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial", Am J Clin Nutr, 90, pp.1433~1439 (2009)
- Arjmandi BH, "One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women", Nutr J, 4, pp.8~ (2005)