The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27kip1
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27kip1 are involved in the cell cycle. This is Jab1 and p27kip1 interact with each other, Jab1 accelerate p27kip1 from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27kip1 is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27kip1 were described in a recent article on the basis of relevant. Besides Jab1 and p27kip1 will organize the relationship between the disease and women. (J Menopausal Med 2016;22:6-8)
Abstract
The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27kip1 are involved in the cell cycle. This is Jab1 and p27kip1 interact with each other, Jab1 accelerate p27kip1 from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27kip1 is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27kip1 were described in a recent article on the basis of relevant. Besides Jab1 and p27kip1 will organize the relationship between the disease and women. (J Menopausal Med 2016;22:6-8)
참고문헌 (18)
- Chamovitz DA, "JAB1", CSN5 and the COP9 signalosome. A complex situation, 2001, pp.2, 96~101
- Schwechheimer C, "COP9 signalosome revisited: a novel mediator of protein degradation", Trends Cell Biol, 11, pp.420~426 (2001)
- Tomoda K, "Degradation of the cyclindependent-kinase inhibitor p27Kip1 is instigated by Jab1", Nature, 398, pp.160~165 (1999)
- Chen F, "Ciglitazoneinduced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway", Cell Signal, 17, pp.1572~1577 (2005)
- Zhang Q, "Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells", FEBS Lett, 579, pp.3932~3940 (2005)
- Bloom J, "Deregulated degradation of the cdk inhibitor p27 and malignant transformation", Semin Cancer Biol, 13, pp.41~47 (2003)
- Hsu MC, "Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2", neu, 2008, pp.21, 609~616
- Adler AS, "Genetic regulators of large-scale transcriptional signatures in cancer", Nat Genet, 38, pp.421~430 (2006)
- Kim TH, "Expression of p27 and Jun activation domain-binding protein 1 in endometriosis", Arch Gynecol Obstet, 292, pp.377~381 (2015)
- Fedele L, "Structural and ultrastructural defects in preovulatory endometrium of normo-ovulating infertile women with minimal or mild endometriosis", Fertil Steril, 53, pp.989~993 (1990)
- Giudice LC, "Endometriosis", Lancet, 364, pp.1789~1799 (2004)
- Wingfield M, "Cell proliferation is increased in the endometrium of women with endometriosis", Fertil Steril, 64, pp.340~346 (1995)
- Gebel HM, "Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis", Fertil Steril, 69, pp.1042~1047 (1998)
- Dmowski WP, "Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis", Hum Reprod, 16, pp.1802~1808 (2001)
- Jemal A, "Cancer statistics, 2004", CA Cancer J Clin, 54, pp.8~29 (2004)
- 박정민, "Hereditary Risk Evaluation for Borderline Ovarian Tumors Based on Immunohistochemistry", 대한폐경학회지, 20(1), pp.14~20 (2014), 대한폐경학회
- Lee WS, "Expression of p53, p27 and Jab1 protein in epithelial ovarian tumors", Eur J Gynaecol Oncol, 33, pp.358~362 (2012)
- Sui L, "Jab1 expression is associated with inverse expression of p27(kip1) and poor prognosis in epithelial ovarian tumors", Clin Cancer Res, 7, pp.4130~4135 (2001)