G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women’s Health
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Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism. (J Menopausal Med 2015;21:79-81)
Abstract
Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism. (J Menopausal Med 2015;21:79-81)
참고문헌 (15)
- Prossnitz ER., "The G-protein-coupled estrogen receptor GPER in health and disease", Nat Rev Endocrinol, 7, pp.715~726 (2011)
- Kolkova Z., "G protein-coupled estrogen receptor 1(GPER, GPR 30)in normal human endometrium and early pregnancy decidua", Mol Hum Reprod, 16, pp.743~751 (2010)
- Owman C., "Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues", Biochem Biophys Res Commun, 228, pp.285~292 (1996)
- McDonnell DP., "Connections and regulation of the human estrogen receptor", Science, 296, pp.1642~1644 (2002)
- Heldring N., "Estrogen receptors : how do they signal and what are their targets", Physiol Rev, 87, pp.905~931 (2007)
- Filardo EJ., "GPR30 : a seven-transmembranespanning estrogen receptor that triggers EGF release", Trends Endocrinol Metab, 16, pp.362~367 (2005)
- Prossnitz ER., "Estrogen signaling through the transmembrane G protein-coupled receptor GPR30", Annu Rev Physiol, 70, pp.165~190 (2008)
- Otto C., "G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol", Endocrinology, 149, pp.4846~4856 (2008)
- Pedram A., "Nature of functional estrogen receptors at the plasma membrane", Mol Endocrinol, 20, pp.1996~2009 (2006)
- Madak-Erdogan Z., "Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors", Mol Endocrinol, 22, pp.2116~2127 (2008)
- Filardo EJ., "Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF", Mol Endocrinol, 14, pp.1649~1660 (2000)
- Bologa CG., "Virtual and biomolecular screening converge on a selective agonist for GPR30", Nat Chem Biol, 2, pp.207~212 (2006)
- Kanda N., "17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression", J Invest Dermatol, 123, pp.319~328 (2004)
- Ylikomi T., "G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid", Eur J Biochem, 271, pp.4159~4168 (2004)
- Ji TH., "G protein-coupled receptors. I. Diversity of receptor-ligand interactions", J Biol Chem, 273, pp.17299~17302 (1998)