Villoglandular Adenocarcinoma of the Uterine Cervix: A Case Report
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Cervical adenocarcinomas constitute for approximately 10%–20% of all invasive cervical cancers. Villoglandular adenocarcinomas (VGAs) are a rare subtype of cervical adenocarcinoma, representing approximately 5% of all cases of cervical adenocarcinomas. Herein, we report the case of a 49-year-old perimenopausal woman successfully treated for VGA. The patient presented to the hospital with a primary complaint of vaginal discharge persisting for 7 months with worsening symptoms. She had no underlying medical conditions or history of oral contraceptive use. A punch biopsy revealed an adenocarcinoma, and a human papillomavirus (HPV) test indicated positive for HPV-16. The patient underwent a radical hysterectomy with bilateral pelvic lymph node dissection, and a pathological diagnosis of VGA was established. After surgery, the patient underwent a 6-week course of concurrent chemoradiotherapy with cisplatin. During the 42 months of follow-up, no signs of disease recurrence or metastasis were observed. Because of the limitations of specimen acquisition, achieving a precise diagnosis through cervicovaginal cytology and punch biopsy is challenging. Instead, conization should be considered to prevent misdiagnosis.
Abstract
Cervical adenocarcinomas constitute for approximately 10%–20% of all invasive cervical cancers. Villoglandular adenocarcinomas (VGAs) are a rare subtype of cervical adenocarcinoma, representing approximately 5% of all cases of cervical adenocarcinomas. Herein, we report the case of a 49-year-old perimenopausal woman successfully treated for VGA. The patient presented to the hospital with a primary complaint of vaginal discharge persisting for 7 months with worsening symptoms. She had no underlying medical conditions or history of oral contraceptive use. A punch biopsy revealed an adenocarcinoma, and a human papillomavirus (HPV) test indicated positive for HPV-16. The patient underwent a radical hysterectomy with bilateral pelvic lymph node dissection, and a pathological diagnosis of VGA was established. After surgery, the patient underwent a 6-week course of concurrent chemoradiotherapy with cisplatin. During the 42 months of follow-up, no signs of disease recurrence or metastasis were observed. Because of the limitations of specimen acquisition, achieving a precise diagnosis through cervicovaginal cytology and punch biopsy is challenging. Instead, conization should be considered to prevent misdiagnosis.
참고문헌 (13)
- Young RH, "Villoglandular papillary adenocarcinoma of the uterine cervix. A clinicopathologic analysis of 13 cases", Cancer, 63, pp.1773~1779 (1989)
- Nagai N, "Villoglandular papillary adenocarcinoma of the uterine cervix responding to neoadjuvant chemotherapy with docetaxel and cisplatin : a case report", Int J Gynecol Cancer, 15, pp.1187~1190 (2005)
- Stolnicu S, "International Endocervical Adenocarcinoma Criteria and Classification(IECC) : a new pathogenetic classification for invasive adenocarcinomas of the endocervix", Am J Surg Pathol, 42, pp.214~226 (2018)
- Hurteau JA, "Villoglandular adenocarcinoma of the cervix : a case report", Obstet Gynecol, 85(5 Pt 2), pp.906~908 (1995)
- González-Bosquet E, "Villoglandular papillary adenocarcinoma of the uterine cervix : a case report and literature review", Eur J Gynaecol Oncol, 30, pp.211~213 (2009)
- Jones MW, "Well-differentiated villoglandular adenocarcinoma of the uterine cervix : a clinicopathological study of 24 cases", Int J Gynecol Pathol, 12, pp.1~7 (1993)
- Zhou QY, "Villoglandular papillary adenocarcinoma of the uterine cervix : a report of 4 cases and a review of the literature", Oncol Lett, 11, pp.837~841 (2016)
- Ogawa M, "Estrogen induces genomic instability in high-risk HPV-infected cervix and promotes the carcinogenesis of cervical adenocarcinoma", Biochem Biophys Res Commun, 659, pp.80~90 (2023)
- Dietl AK, "Villoglandular adenocarcinoma of the uterine cervix : a systematic review and metaanalysis", Arch Gynecol Obstet, 304, pp.317~327 (2021)
- Lakhtakia R, "Villoglandular papillary adenocarcinoma of the cervix : case report", J Surg Oncol, 74, pp.297~299 (2000)
- Liu X, "Cervical villoglandular adenocarcinoma : a rare case report and review of the literature", Eur J Gynaecol Oncol, 43, pp.152~156 (2022)
- Salek G, "Villoglandular papillary adenocarcinoma : case report", Pan Afr Med J, 25, pp.232~ (2016)
- Stanley-Christian H, "Villoglandular adenocarcinoma of the cervix : a report of three cases and review of the literature", Gynecol Oncol, 66, pp.327~330 (1997)