본문 바로가기
KERD
논문KCI 등재

간암 줄기세포의 기원

Cellular origin of liver cancer stem cells

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류의학일반

초록

Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver CSCs. Clinically HCCs show a wide range of manifestations from slow growth to very aggressive metastasis. One of the reasons may be that liver CSCs originate from different cells. This review describes the basic concept of CSCs and the cellular origin of liver CSCs.

Abstract

Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver CSCs. Clinically HCCs show a wide range of manifestations from slow growth to very aggressive metastasis. One of the reasons may be that liver CSCs originate from different cells. This review describes the basic concept of CSCs and the cellular origin of liver CSCs.

참고문헌 (51)

  1. Lafaro KJ, "Epidemiology of hepatocellular carcinoma", Surg Oncol Clin N Am, 24, pp.1~17 (2015)
  2. 윤승규, "The Biology of Cancer Stem Cells and Its Clinical Implication in Hepatocellular Carcinoma", Gut and Liver, 6(1), pp.29~40 (2012), 거트앤리버 발행위원회
  3. Sasaki M, "Clinicopathological significance of ‘subtypes with stem-cell feature’ in combined hepatocellular-cholangiocarcinoma", Liver Int, 35, pp.1024~1035 (2015)
  4. Bucher NLR, "Regeneration of liver and kidney" (1971), Little Brown
  5. Duncan AW, "Stem cells and liver regeneration", Gastroenterology, 137, pp.466~481 (2009)
  6. Zajicek G, "The streaming liver", Liver, 5, pp.293~300 (1985)
  7. Fellous TG, "Locating the stem cell niche and tracing hepatocyte lineages in human liver", Hepatology, 49, pp.1655~1663 (2009)
  8. Eckersley-Maslin MA, "Bone marrow stem cells and the liver: are they relevant?", J Gastroenterol Hepatol, 24, pp.1608~1616 (2009)
  9. Almeida-Porada G, "Formation of human hepatocytes by human hematopoietic stem cells in sheep", Blood, 104, pp.2582~2590 (2004)
  10. Shackel N, "In pursuit of the “Holy Grail”--stem cells, hepatic injury, fibrogenesis and repair", Hepatology, 41, pp.16~18 (2005)
  11. Wang X, "Cell fusion is the principal source of bone-marrow-derived hepatocytes", Nature, 422(6934), pp.897~901 (2003)
  12. Alison MR, "Hepatocytes from non-hepatic adult stem cells", Nature, 406(6793), pp.257~ (2000)
  13. Theise ND, "Teperman L, et al. Liver from bone marrow in humans", Hepatology, 32, pp.11~16 (2000)
  14. Ying QL, "Changing potency by spontaneous fusion", Nature, 416(6880), pp.545~548 (2002)
  15. Lagasse E, "Purified hematopoietic stem cells can differentiate into hepatocytes in vivo", Nat Med, 6, pp.1229~1234 (2000)
  16. Jang YY, "Hematopoietic stem cells convert into liver cells within days without fusion", Nat Cell Biol, 6, pp.532~539 (2004)
  17. Harris RG, "Lack of a fusion requirement for development of bone marrow-derived epithelia", Science, 305(5680), pp.90~93 (2004)
  18. Zeisberg M, "Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition", J Biol Chem, 282(32), pp.23337~23347 (2007)
  19. Fausto N, "Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells", Hepatology, 39, pp.1477~1487 (2004)
  20. Jirtle RL, "Modulation of insulin-like growth factor-II", mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration, 1991, pp.266(33), 22444~22450
  21. Marquardt JU, "Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications", J Hepatol, 53, pp.568~577 (2010)
  22. Reya T, "Stem cells, cancer, and cancer stem cells", Nature, 414(6859), pp.105~111 (2001)
  23. Sell S, "Liver cancer stem cells", J Clin Oncol, 26, pp.2800~2805 (2008)
  24. Oishi N, "Novel therapeutic strategies for targeting liver cancer stem cells", Int J Biol Sci, 7, pp.517~535 (2011)
  25. Coulouarn C, "Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties", Oncogene, 28, pp.3526~3536 (2009)
  26. Pineau P, "miR-221 overexpression contributes to liver tumorigenesis", Proc Natl Acad Sci U S A, 107, pp.264~269 (2010)
  27. Ma S, "miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1", Cell Stem Cell, 7, pp.694~707 (2010)
  28. Wong QW, "MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1", Gastroenterology, 135, pp.257~269 (2008)
  29. Wong QW, "MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling", Clin Cancer Res, 16, pp.867~875 (2010)
  30. Ji J, "Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells", Hepatology, 50, pp.472~480 (2009)
  31. Libbrecht L, "Hepatic progenitor cells in human liver diseases", Semin Cell Dev Biol, 13, pp.389~396 (2002)
  32. Theise ND, "The canals of Hering and hepatic stem cells in humans", Hepatology, 30, pp.1425~1433 (1999)
  33. Kordes C, "Hepatic stem cell niches", J Clin Invest, 123, pp.1874~1880 (2013)
  34. Durnez A, "The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin", Histopathology, 49, pp.138~151 (2006)
  35. Gerlach JC, "Perivascular mesenchymal progenitors in human fetal and adult liver", Stem Cells Dev, 21, pp.3258~3269 (2012)
  36. Yin S, "CD133positive hepatocellular carcinoma cells possess high capacity for tumorigenicity", Int J Cancer, 120, pp.1444~1450 (2007)
  37. Piao LS, "CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma", Cancer Lett, 315, pp.129~137 (2012)
  38. Ma S, "Aldehyde dehydrogenase discriminates the CD133liver cancer stem cell populations", Mol Cancer Res, 6, pp.1146~1153 (2008)
  39. Zhu Z, "Cancer stem", progenitor cells are highly enriched in CD133+CD44+population in hepatocellular carcinoma, 2010, pp.126, 2067~2078
  40. Yang ZF, "Significance of CD90+ cancer stem cells in human liver cancer", Cancer Cell, 13, pp.153~166 (2008)
  41. Yamashita T, "EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem", progenitor cell features, 2009, pp.136, 1012~1024
  42. Park SC, "Identification of cancer stem cell subpopulations of CD34(+) PLC", PRF, Stem Cells Dev, pp.2015, 24[DOI]
  43. Park SC, "Clonogenically culturing and expanding CD34+liver cancer stem cells in vitro", Stem Cells Dev (2015)
  44. Holczbauer A, "Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types", Gastroenterology, 145, pp.221~231 (2013)
  45. Bralet MP, "Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats", Hepatology, 36, pp.623~630 (2002)
  46. Nagaki M, "Regulation of hepatic genes and liver transcription factors in rat hepatocytes by extracellular matrix", Biochem Biophys Res Commun, 210, pp.38~43 (1995)
  47. Blaheta RA, "Dedifferentiation of human hepatocytes by extracellular matrix proteins in vitro: quantitative and qualitative investigation of cytokeratin 7, 8, 18, 19 and vimentin filaments", J Hepatol, 28, pp.677~690 (1998)
  48. Xu J, "TGF-beta-induced epithelial to mesenchymal transition", Cell Res, 19, pp.156~172 (2009)
  49. Dubois-Pot-Schneider H, "Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells", Hepatology, 60, pp.2077~2090 (2014)
  50. Lowes KN, "Oval cell numbers in human chronic liver diseases are directly related to disease severity", Am J Pathol, 154, pp.537~541 (1999)
  51. Eun JR, "Hepatoma SK Hep-1 cells exhibit characteristics of oncogenic mesenchymal stem cells with highly metastatic capacity", PLoS One, 9(10), pp.e110744~ (2014)

관련 논문AI추천

이 간행물의 다른 논문 (13건)