Mammary Paget’s disease without underlying malignancy of the breast
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Mammary Paget’s disease (MPD) is usually accompanied by underlying breast malignancy; however, a few cases have been reported as only skin lesions without any evidence of malignancy of the breast on imaging tests and microscopic examination of surgical specimen. Here, we describe a 47-year-old woman who visited our hospital who had an eczematous lesion on right nipple and areola for over 10 years. The lesion was diagnosed as Paget’s disease by punch biopsy; however, imaging studies demonstrated no breast malignancy or lymph node metastasis. The patient underwent surgery of on the nipple and areola including underlying breast tissue. No underlying malignancy was found upon microscopic examination, except for Paget’s disease. Immunohistochemical stains revealed that the tumor cells were positive for cytokeratin 7, and negativity for p63, cytokeratin 5/6, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. We report a case of MPD without underlying malignancy. To the best of our knowledge, this is the third case reported in Korea.
Abstract
Mammary Paget’s disease (MPD) is usually accompanied by underlying breast malignancy; however, a few cases have been reported as only skin lesions without any evidence of malignancy of the breast on imaging tests and microscopic examination of surgical specimen. Here, we describe a 47-year-old woman who visited our hospital who had an eczematous lesion on right nipple and areola for over 10 years. The lesion was diagnosed as Paget’s disease by punch biopsy; however, imaging studies demonstrated no breast malignancy or lymph node metastasis. The patient underwent surgery of on the nipple and areola including underlying breast tissue. No underlying malignancy was found upon microscopic examination, except for Paget’s disease. Immunohistochemical stains revealed that the tumor cells were positive for cytokeratin 7, and negativity for p63, cytokeratin 5/6, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. We report a case of MPD without underlying malignancy. To the best of our knowledge, this is the third case reported in Korea.
참고문헌 (20)
- Haagensen CD, "The physiology of the breast as it concerns the clinician", Am J Obstet Gynecol, 109, pp.206~209 (1971)[DOI]
- Lagios MD, "Paget's disease of the nipple. Alternative management in cases without or with minimal extent of underlying breast carcinoma", Cancer, 54, pp.545~551 (1984)[DOI]
- Jones RE Jr, "Mammary Paget's disease without underlying carcinoma", Am J Dermatopathol, 7, pp.361~365 (1985)[DOI]
- Campana F, "Paget's disease of the nipple without any associated mammary tumor clinically or radiologically detectable. Apropos of 51 cases treated at the Curie Institute", J Gynecol Obstet Biol Reprod (Paris), 16, pp.1069~1073 (1987)
- Mori O, "A case of mammary Paget's disease without an underlying carcinoma: microscopic analysis of the DNA content in Paget cells", J Dermatol, 21, pp.160~165 (1994)[DOI]
- Pranteda G, "Mammary Paget's disease with acantholytic features and without any detectable breast tumor", J Exp Clin Cancer Res, 17, pp.519~522 (1998)
- Caliskan M, "Paget's disease of the breast: the experience of the European Institute of Oncology and review of the literature", Breast Cancer Res Treat, 112, pp.513~521 (2008)[DOI]
- Lim HS, "Paget disease of the breast: mammographic, US, and MR imaging findings with pathologic correlation", Radiographics, 31, pp.1973~1987 (2011)[DOI]
- Bansal S, "A rare presentation of mammary Paget's disease involving the entire breast in the absence of any underlying ductal malignancy", Indian J Dermatol Venereol Leprol, 79, pp.518~521 (2013)[DOI]
- Lloyd J, "Mammary and extramammary Paget's disease", J Clin Pathol, 53, pp.742~749 (2000)[DOI]
- Dalberg K, "Paget's disease of the nipple in a population based cohort", Breast Cancer Res Treat, 111, pp.313~319 (2008)[DOI]
- Chen CY, "Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S.", Cancer, 107, pp.1448~1458 (2006)[DOI]
- Siponen E, "Surgical treatment in Paget's disease of the breast", Am J Surg, 200, pp.241~246 (2010)[DOI]
- Liegl B, "Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases", Histopathology, 50, pp.439~447 (2007)[DOI]
- Meissner K, "Study of neu-protein expression in mammary Paget's disease with and without underlying breast carcinoma and in extramammary Paget's disease", Am J Pathol, 137, pp.1305~1309 (1990)
- Liu W, "Mammary Paget's disease and extramammary Paget's disease: two morphologically similar but biologically different diseases", J Cutan Pathol, 37, pp.1145~1149 (2010)[DOI]
- Kuan SF, "Differential expression of mucin genes in mammary and extramammary Paget's disease", Am J Surg Pathol, 25, pp.1469~1477 (2001)[DOI]
- Ling H, "Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study", PLoS One, 8, pp.e61455~ (2013)[DOI]
- Han JY, "Two cases of Paget's disease", Korean J Dermatol, 14, pp.255~260 (1976)
- Yeo JY, "Clinical observations on Paget's disease of the breast", J Korean Surg Soc, 47, pp.366~373 (1994)