한국여성에서 임신 초기 갑상선기능의 평가
Maternal Thyroid Function during the First Trimester of Pregnancy in Korean Women
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Background and Objectives: Thyroid dysfunction during pregnancy can result in many complications for both mother and infant. Due to the physiologic changes in thyroid stimulating hormone (TSH) level during early pregnancy, it is recommend to use trimester-specific reference ranges for every population. We obtained the reference range of TSH during the first trimester in Korean women according to gestational week. Materials and Methods: The study population consisted of pregnant women who had undergone a TSH screening during the first trimester of pregnancy (n=8365) and nonpregnant women (n=1835). Results: Median concentration of serum TSH decreased significantly from the 5th to 8th week of gestation (median TSH concentration: 2.00 mIU/L for 5 weeks; 1.70 mIU/L for 6 weeks; 1.40 mIU/L for 7 weeks; 1.05 mIU/L for 8 weeks). However, there was no significant difference in median concentration of serum TSH from the 8th to 12th weeks of gestation. Using the fixed cut-off value of TSH ＞3.66 mIU/L, the diagnosis rate of subclinical hypothyroidism was 15.0% for 5 weeks, 10.0% for 6 weeks, 5.9% for 7 weeks, and 3.6% for 8-12 weeks. Conclusion: When interpreting the TSH test for pregnancy (maternal thyroid function), we should consider that the TSH level decreases significantly during the early first trimester.
Abstract
Background and Objectives: Thyroid dysfunction during pregnancy can result in many complications for both mother and infant. Due to the physiologic changes in thyroid stimulating hormone (TSH) level during early pregnancy, it is recommend to use trimester-specific reference ranges for every population. We obtained the reference range of TSH during the first trimester in Korean women according to gestational week. Materials and Methods: The study population consisted of pregnant women who had undergone a TSH screening during the first trimester of pregnancy (n=8365) and nonpregnant women (n=1835). Results: Median concentration of serum TSH decreased significantly from the 5th to 8th week of gestation (median TSH concentration: 2.00 mIU/L for 5 weeks; 1.70 mIU/L for 6 weeks; 1.40 mIU/L for 7 weeks; 1.05 mIU/L for 8 weeks). However, there was no significant difference in median concentration of serum TSH from the 8th to 12th weeks of gestation. Using the fixed cut-off value of TSH ＞3.66 mIU/L, the diagnosis rate of subclinical hypothyroidism was 15.0% for 5 weeks, 10.0% for 6 weeks, 5.9% for 7 weeks, and 3.6% for 8-12 weeks. Conclusion: When interpreting the TSH test for pregnancy (maternal thyroid function), we should consider that the TSH level decreases significantly during the early first trimester.
참고문헌 (28)
- Stagnaro-Green A., "Overt hyperthyroidism and hypothyroidism during pregnancy", Clin Obstet Gynecol, 54(3), pp.478~487 (2011)
- Casey BM, "Thyroid disease in pregnancy", Obstet Gynecol, 108(5), pp.1283~1292 (2006)
- Vaidya B, "Detection of thyroid dysfunction in early pregnancy: Universal screening or targeted high-risk case finding?", J Clin Endocrinol Metab, 92(1), pp.203~207 (2007)
- Horacek J, "Universal screening detects two-times more thyroid disorders in early pregnancy than targeted high-risk case finding", Eur J Endocrinol, 163(4), pp.645~650 (2010)
- Glinoer D, "Serum TSH determinations in pregnancy: how, when and why?", Nat Rev Endocrinol, 6(9), pp.526~529 (2010)
- Stagnaro-Green A, "Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum", Thyroid, 21(10), pp.1081~1125 (2011)
- De Groot L, "Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline", J Clin Endocrinol Metab, 97(8), pp.2543~2565 (2012)
- Lazarus J, "2014 European Thyroid Association guidelines for the management of subclinical hypothyroidism in pregnancy and in children", Eur Thyroid J, 3(2), pp.76~94 (2014)
- Li C, "Assessment of thyroid function during first-trimester pregnancy:what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women?", J Clin Endocrinol Metab, 99(1), pp.73~79 (2014)
- Blatt AJ, "National status of testing for hypothyroidism during pregnancy and postpartum", J Clin Endocrinol Metab, 97(3), pp.777~784 (2012)
- Stagnaro-Green A., "Postpartum management of women begun on levothyroxine during pregnancy", Front Endocrinol (Lausanne), 6, pp.183~ (2015)
- Alexander EK, "Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum", Thyroid, 27(3), pp.315~389 (2017)
- Klein RZ, "Prevalence of thyroid deficiency in pregnant women", Clin Endocrinol (Oxf), 35(1), pp.41~46 (1991)
- Casey BM, "Subclinical hypothyroidism and pregnancy outcomes", Obstet Gynecol, 105(2), pp.239~245 (2005)
- Glinoer D, "The regulation of thyroid function in pregnancy:pathways of endocrine adaptation from physiology to pathology", Endocr Rev, 18(3), pp.404~433 (1997)
- Maraka S, "Subclinical hypothyroidism in pregnancy: a systematic review and meta-analysis", Thyroid, 26(4), pp.580~590 (2016)
- Glinoer D., "Thyroid hyperfunction during pregnancy", Thyroid, 8(9), pp.859~864 (1998)
- Ballabio M, "Pregnancy-induced changes in thyroid function: role of human chorionic gonadotropin as putative regulator of maternal thyroid", J Clin Endocrinol Metab, 73(4), pp.824~831 (1991)
- Medici M, "Thyroid function in pregnancy: what is normal?", Clin Chem, 61(5), pp.704~713 (2015)
- McNeil AR, "Reporting thyroid function tests in pregnancy", Clin Biochem Rev, 36(4), pp.109~126 (2015)
- Negro R, "Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy", J Clin Endocrinol Metab, 95(4), pp.1699~1707 (2010)
- Li Y, "Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30months", Clin Endocrinol (Oxf), 72(6), pp.825~829 (2010)
- Su PY, "Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development: a prospective population-based cohort study in China", J Clin Endocrinol Metab, 96(10), pp.3234~3241 (2011)
- Bryant SN, "An analysis of population-based prenatal screening for overt hypothyroidism", Am J Obstet Gynecol, 213(4), pp.565 e1~565 e6 (2015)
- Laurberg P, "Dynamics and predictors of serum TSH and fT4 reference limits in early pregnancy: a study within the Danish National Birth Cohort", J Clin Endocrinol Metab, 101(6), pp.2484~2492 (2016)
- 김혜성, "Gestational Age-specific Cut-off Values Are Needed for Diagnosis of Subclinical Hypothyroidism in Early Pregnancy", Journal of Korean Medical Science, 30(9), pp.1308~1312 (2015), 대한의학회
- Rosario PW, "Should pregnant women older than 30 years without risk factors be investigated for thyroid dysfunction?", Thyroid, 22(4), pp.445~446 (2012)
- Zhang X, "Reference intervals of thyroid function during pregnancy:self-sequential longitudinal study versus cross-sectional study", Thyroid, 26(12), pp.1786~1793 (2016)