기면증의 뇌형태 변화
Morphological Changes in Narcolepsy
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Narcolepsy is a chronic neurological disorder with the abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and manifestations related to REM sleep such as cataplexy, sleep paralysis, and hypnagogic hallucination. Over the past decade, numerous neuroimaging studies, have been performed to characterize the pathophysiology and various clinical features of narcolepsy. Here we review structural findings based on brain magnetic resonance imaging in narcolepsy with cataplexy, which include voxel-based morphometry, cortical thickness analyses, and hippocampal volumetry. The current state of research suggests that structural neuroimaging is a useful tool to investigate and understand the anatomical correlates and brain abnormalities of narcolepsy.
Abstract
Narcolepsy is a chronic neurological disorder with the abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and manifestations related to REM sleep such as cataplexy, sleep paralysis, and hypnagogic hallucination. Over the past decade, numerous neuroimaging studies, have been performed to characterize the pathophysiology and various clinical features of narcolepsy. Here we review structural findings based on brain magnetic resonance imaging in narcolepsy with cataplexy, which include voxel-based morphometry, cortical thickness analyses, and hippocampal volumetry. The current state of research suggests that structural neuroimaging is a useful tool to investigate and understand the anatomical correlates and brain abnormalities of narcolepsy.
참고문헌 (25)
- Thannickal TC, "Reduced number of hypocretin neurons in human narcolepsy", Neuron, 27, pp.469~474 (2000)
- Taheri S, "The role of hypocretins (orexins) in sleep regulation and narcolepsy", Annu Rev Neurosci, 25, pp.283~313 (2002)
- Sakurai T, "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior", Cell, 92, pp.573~585 (1998)
- Nishino S, "Hypocretin (orexin) deficiency in human narcolepsy", Lancet, 355, pp.39~40 (2000)
- Plazzi G, "Pontine lesions in idiopathic narcolepsy", Neurology, 46, pp.1250~1254 (1996)
- Bassetti C, "MRI findings in narcolepsy", Sleep, 20, pp.630~631 (1997)
- Frey JL, "Absence of pontine lesions in narcolepsy", Neurology, 48, pp.1097~1099 (1997)
- Desseilles M, "Neuroimaging insights into the pathophysiology of sleep disorders", Sleep, 31, pp.777~794 (2008)
- Draganski B, "Hypothalamic gray matter changes in narcoleptic patients", Nat Med, 8, pp.1186~1188 (2002)
- Overeem S, "Voxel-based morphometry in hypocretin-deficient narcolepsy", Sleep, 26, pp.44~46 (2003)
- Buskova J, "Reduced hypothalamic gray matter in narcolepsy with cataplexy", Neuro Endocrinol Lett, 27, pp.769~772 (2006)
- Kaufmann C, "Reduced cortical gray matter in narcolepsy: preliminary findings with voxel-based morphometry", Neurology, 58, pp.1852~1855 (2002)
- Brenneis C, "Voxel-based morphometry in narcolepsy", Sleep Med, 664, pp.531~536 (2005)
- 주은연, "Gray Matter Concentration Abnormality in Brains of Narcolepsy Patients", Korean Journal of Radiology, 10(6), pp.552~558 (2009), 대한영상의학회
- Rieger M, "Attention deficits in patients with narcolepsy", Sleep, 26, pp.36~43 (2003)
- Good CD, "A voxel-based morphometric study of ageing in 465 normal adult human brains", Neuroimage, 14(1 Pt 1), pp.21~36 (2001)
- Fischl B, "Measuring the thickness of the human cerebral cortex from magnetic resonance images", Proc Natl Acad Sci U S A, 97, pp.11050~11055 (2000)
- Kabani N, "Measurement of cortical thickness using an automated 3-D algorithm: a validation study", Neuroimage, 13, pp.375~380 (2001)
- Hutton C, "A comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging", Neuroimage, 48, pp.371~380 (2009)
- Im K, "Gender difference analysis of cortical thickness in healthy young adults with surface-based methods", Neuroimage, 31, pp.31~38 (2006)
- Joo EY, "Analysis of cortical thickness in narcolepsy patients with cataplexy", Sleep, 34, pp.1357~1364 (2011)
- Schulz H, "Cognitive deficits in patients with daytime sleepiness", Acta Neurol Belg, 97, pp.108~112 (1997)
- Joo EY, "Cerebral perfusion abnormality in narcolepsy with cataplexy", Neuroimage, 28, pp.410~416 (2005)
- Joo EY, "Glucose hypometabolism of hypothalamus and thalamus in narcolepsy", Ann Neurol, 56, pp.437~440 (2004)
- Joo EY, "Hippocampal volume and memory in narcoleptics with cataplexy", Sleep Med, 13, pp.396~401 (2012)