소아의 비안와 두경부 횡문근육종의 치료 결과와 예후 인자

Abstract

Background and Objectives：The survival rate for rhabdomyosarcoma has been improved much after introduction of mul-timodality treatment. We reviewed the treatment results and investigated the related prognostic factors of pediatric nonorbital head and neck rhabdomyosarcoma. Materials and Method：Medical records of 27 children treated for nonorbital head and neck rhabdomyosarcoma from January 1986 to December 2000 were analyzed. Patients ages at diagnosis ranged from 1 to 169 months (mean：75 months). The pathologic subtypes were predominantly embryonal with 23 patients (85% ), followed by alveolar subtype with 1 (4% ), and uncertain one with 3 (11% ). Results：The overall 5-year survival rate was 69%. Of 27 (41% ) had cranial nerve involvement with frequent abducens nerve and facial nerve involvement. Ten (37% ) had skull base or brain invasion. The 5-year survival of patients with skull base or brain invasion was 40% and without skull base or brain invasion was 88%. Parameningeal site (68% vs 71% ) and cranial nerve involvement (64% vs 73% ) were not significant prognostic factors. Conclusion：Skull base or brain invasion was an important prognostic factor. There is no indication of initial agressive surgical resection for the (Korean J Otolaryngol 203 ;46 :965-70)