Clinical and Cytogenetic Profiles of Rhabdomyosarcoma with Bone Marrow Involvement in Korean Children: A 15-Year Single-Institution Experience
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Alveolar RMS (ARMS) is characterized by FOXO1-related chromosomal translocations that result in a poorer clinical outcome compared with embryonal RMS (ERMS). Because the chromosomal features of RMS have not been comprehensively defined, we analyzed the clinical and laboratory data of childhood RMS patients and determined the clinical significance of chromosomal abnormalities in the bone marrow.
Abstract
Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Alveolar RMS (ARMS) is characterized by FOXO1-related chromosomal translocations that result in a poorer clinical outcome compared with embryonal RMS (ERMS). Because the chromosomal features of RMS have not been comprehensively defined, we analyzed the clinical and laboratory data of childhood RMS patients and determined the clinical significance of chromosomal abnormalities in the bone marrow.
참고문헌 (17)
- Punyko JA, "Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based evaluation", Cancer, 103, pp.1475~1483 (2005)[DOI]
- Barr FG, "Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group", Genes Chromosomes Cancer, 48, pp.661~672 (2009)[DOI]
- Agamanolis DP, "Tumors of skeletal muscle", Hum Pathol, 17, pp.778~795 (1986)[DOI]
- Sangkhathat S, "Current management of pediatric soft tissue sarcomas", World J Clin Pediatr, 4, pp.94~105 (2015)[DOI]
- Vleeshouwer-Neumann T, "Histone deacetylase inhibitors antagonize distinct pathways to suppress tumorigenesis of embryonal rhabdomyosarcoma", PLoS One, 10, pp.e0144320~ (2015)[DOI]
- Goldstein M, "Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors", Neoplasia, 8, pp.332~343 (2006)[DOI]
- Sorensen PH, "PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group", J Clin Oncol, 20, pp.2672~2679 (2002)[DOI]
- Slater O, "Clinical relevance of molecular genetics to paediatric sarcomas", J Clin Pathol, 60, pp.1187~1194 (2007)[DOI]
- Krskova L, "Detection and clinical significance of bone marrow involvement in patients with rhabdomyosarcoma", Virchows Archiv, 456, pp.463~472 (2010)[DOI]
- Keller C, "Mechanisms of impaired differentiation in rhabdomyosarcoma", FEBS J, 280, pp.4323~4334 (2013)[DOI]
- Sultan I, "Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients", J Clin Oncol, 27, pp.3391~3397 (2009)[DOI]
- Hosoi H, "A review of 331 rhabdomyosarcoma cases in patients treated between 1991 and 2002 in Japan", Int J Clin Oncol, 12, pp.137~145 (2007)[DOI]
- Weiss AR, "Histologic and clinical characteristics can guide staging evaluations for children and adolescents with rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee", J Clin Oncol, 31, pp.3226~3232 (2013)[DOI]
- Ognjanovic S, "Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005", Cancer, 115, pp.4218~4226 (2009)[DOI]
- Schmitt-Ney M, "The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-<TEX>${\beta}$<", TEX> pathway, 2015, pp.10, e0121474~
- Barr FG, "Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions", Cancer Res, 62, pp.4704~4710 (2002)
- Sumegi J, "Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator (NCOA) family", Genes Chromosomes Cancer, 49, pp.224~236 (2010)
