두경부 암의 예후인자로서의 SUV 측정의 분석

Abstract

Background and Objectives：Previous studies have shown that uptake of 18Fluoro-2-deoxy-glucose in head and neck cancer, as determined by the standardized uptake value (SUV) on positron emission tomography scan (PET scan), is associated with the biology of tumor. The aims of this study were to confirm the association with the biology of tumor and to establish whether a high SUV had prognostic significance. Materials and Method：Thirty patients with the head and neck cancer diagnosed as squamous cell carcinoma underwent a PET scan before treatment. SUVs were analyzed for possibility correlated with disease-free survival. Results：In univariate survival analysis, when patients were divided into two groups based on the SUV cut-off (p= 0.029). Corelation analysis demonstrated that SUV provided prognostic information independent of the tumor size, pathologic differentiation and stage. Conclusion：We conclude that high FDG uptake on PET (SUV >8 in pre-treatment PET scan) is an important prognostic indicator for poor outcome. Identified patients are thought to require intensive treatment protocol and more careful follow up.(Korean J Otolaryngol 2003 ;46 :955-8)