기니픽 와우에 대한 리도카인 미세관류의 청각적 효과
Auditory Effects of Microperfused Lidocaine on Guinea Pig Cochlea
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Abstract
Objectives：Lidocaine is one of the therapeutic trials to treat tinnitus. However, the exact mechanism of the efect of lidocaine remains unclear. The aim of this study was to elucidate the action site of lidocaine in the cochlea by measuring compound action potential (CAP) and transient evoked otoacoustic emission (TEOAE) amplitude in guinea pigs. Method：Artificial perilymph was perfused into the scala tympani of the guinea pig cochlea in the control group, and lidocaine diluted with artificial perilymph was perfused into the scala tympani of the experimental groups. Electrocochleogram (ECoG) and TEOAE were measured in each groups both before and after lidocaine perfusion. Results：Artificial perilymph perfused to the scala tympani of the guinea the guinea pig cochleae produced a dose-dependent increase in CAP threshold, but did not affect TEOAE response. Conclusion：This study revealed that lidocaine perfused into the scala tympani of the guinea pig cochlea affects the CAPthreshold but not the TEOAE amplitude and reproducibility. It means that the localy perfused lidocaine affects the cochlear nerve greater than the outer hair cells. (Korean J Otolaryngol 2004 ;47 :9-14)
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