중이내 젠타마이신 일회성 투여 후 전정 신경의 반응 변화
Changes in Activity of Vestibular Afferents after Intratympanic Gentamicin Single Injection
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Abstract
Background and Objectives：Aminoglycoside antibiotics are toxic to hair cells of the inner ear. Recently, intratympanic gentamicininjection is widely accepted as a treatment modality for Meniere’s disease. Subjects and Method：We treated anesthetizedchinchillas with one injection of gentamicin into the middle ear and made extracellular recordings from afferents afterthree to four weeks. Results：The spontaneous firing rate of regular and irregular afferents was lower (p<0.05) on the treatedside than on the untreated side. The relative proportions of regular, intermediate, and irregular afferents did not change aftertreatment. The majority of the treated afferents did not significantly respond to rotation, and those that did respond had abnormallylow levels of sensitivity. Sensitivity to externally applied galvanic currents was unaffected. Conclusion：These findingssuggest that a single intratympanic gentamicin injection preserves enough hair cell synaptic activity to drive the spontaneousactivity of vestibular afferents, and does not damage the afferent spike initiation zones.
참고문헌 (22)
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