갑상선 유두상 암종에서 S100A4와 S100A2의 발현과임상 양상과의 관계
Expression of S100A4 and S100A2 is Associated with ClinicopathologicFeatures in Papillary Thyroid Carcinoma
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Abstract
Background and Objectives：S100 calcium-binding proteins are known to play multiple roles in progression and invasion of various carcinomas. In this study, we focused on two kinds of these proteins, S100A4 and S100A2, and investigated their expressions in thyroid neoplasm. Subjects and Method：We investigated S100A4 and S100A2 expressions in 75 thyroid neoplasms by immunohistochemistry. Results：S100A4 and S100A2 were not expressed in normal thyroid follicles or follicular carcinomas. Positive relationships were established between S100A4 expression and size (p=.014), invasiveness (p=.029) and T stage (p=.004) of papillary carcinomas. Especially, the S100A4 expression was observed more frequently in the peripheral area (p=.046). But there was no correlation between S100A4 expression with multiple tumor formation and lymph node me-tastasis. Positive relationships were established between S100A2 expression and size (p=.041), invasiveness (p=.008) and T stage (p<.001) of papillary carcinomas. S100A4 expression was also observed more frequently in the peripheral area (p=.001). Conclusion: These findings suggest that S100A4 and S100A2 contribute to the progression and local invasion of thyroid carcinoma. (Korean J Otolaryngol 2007 ;50 :319-26)
참고문헌 (20)
- Wang TS, "Incidence of metastatic well-differentiated thyroid cancer in cervical lymph nodes", 130(1), pp.110~113 (2004)
- Andersen PE, "Differentiated carcinoma of the thyroid with extrathyroidal extension", 170(5), pp.467~470 (1995)
- Heizmann CW, "The multifunctional S100 protein family", 172, pp.69~80 (2002)
- Wang H, "Overexpressionof S100A2 protein as a prognostic marker for patientswith stage I non small cell lung cancer", pp.285~90
- Sherbet GV, "S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis", 18(4A), pp.2415~2421 (1998)
- Gupta S, "Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma", 21(1), pp.106~112 (2003)
- Davies BR, "Expression of S100A4 protein is associated with metastasis and reduced survival in human bladder cancer", 196(3), pp.292~299 (2002)
- Cho YG, "Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer", 111(5), pp.539~545 (2003)
- Tan M, "ranscriptional activation of the human S100A2 protein by wild-type p53", 445(2-3), pp.265~268 (1999)
- Lauriola L, "Prognostic significance of the Ca2+ binding protein S100A2 in laryngeal squamous-cell carcinoma", 89(4), pp.345~349 (2000)
- Imazawa M, "S100A2 overexpression is frequently observed in esophageal squamous cell carcinoma", 25(2B), pp.1247~1250 (2005)
- Wang H, "Overexpression of S100A2 protein as a prognostic marker for patients with stage I non small cell lung cancer", 116(2), pp.285~290 (2005)
- "S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer", 64(16), pp.5564~5569 (2004)
- "Fine-needle aspiration diagnosis of the follicular variant of papillary carcinoma", 84(6), pp.349~354 (1998)
- "Association of S100A4 mRNA expression with differentiation and metastasis of renal cell carcinoma", 25(6), pp.712~714 (2005)
- "Overexpression of S100A4 is closely associated with progression of colorectal cancer", 11(31), pp.4852~4856 (2005)
- "Suppression of tumor development and metastasis formation in mice lacking the S100A4 (mts1) gene", 65(9), pp.3772~3780 (2005)
- "Microarray analysis of metastasis-associated gene expression profiling in a murine model of thyroid carcinoma pulmonary metastasis: Identification of S100A4 (Mts1) gene overexpression as a poor prognostic marker for thyroid carcinoma", 89(12), pp.6146~6154 (2004)
- "S100A4 expression is an early event of papillary carcinoma of the thyroid", 67(5-6), pp.397~402 (2004)
- "Expression of S100A2 and S100A6 in thyroid carcinomas", 46(5), pp.569~575 (2005)