후두 편평상피암에서 β-catenin과 AdenomatousPolyposis Coli(APC) 단백의 발현
Expression of β-catenin and Adenomatous Polyposis Coli(APC)Protein in Squamous Cell Carcinoma of the Laryngeal Cancers
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Abstract
Background and Objectives：β-catenin has an esential role in intercellular adhesion and signal transduction. The Adeno-matous poliposis coli (APC) protein interacts with β-catenin in a multi-protein complex to regulate the level of expresion of β-catenin. Mutations in β-catenin or APC gene can lead to the accumulation of β-catenin in the cytosol and the nucleus. This study was designed to investigate the expresion of APC and β-catenin in laryngeal cancer. Subjects and Method：Imunohistochemical methods were used to determine the β-catenin and APC protein expresion in 15 laryngeal cancers. Re-sults were correlated with clinicopathological parameters. Results：β-catenin expression to the plasma membrane was reduced or absent in 11 of 15 cases (73% ) of the laryngeal cancers. Cytoplasmic expression of the β-catenin was seen in 6 out of 15 cases (40% ). APC imunoactivity was negative in 5 of 15 (33% ) of the laryngeal cancers. One of the six cytoplasmic expressions of the β-catenin was negative for APC imunoactivity, and one of the five negative for APC imunoactivity was cytoplasmic expresion of the β-catenin. Conclusion：There was no correlation between βanalysis. This finding sugests that cytoplasmic expression of the β-catenin resulted not from the APC mutation but from the β-catenin mutation and abnormal Wnt signal. Only the expression of the β-catenin in cytoplasm was associated with lymph node metastasis.
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