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인후두역류증의 진단：식도점막 생검의 의의

The Diagnosis of Laryngopharyngeal Reflux：The Role of Esophageal Mucosal Biopsy

이승환|김수영|이용섭|정진혁|한동수|박용욱|태경
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2006.01|대한이비인후과학회지 두경부외과학 (Korean Journal of Otorhinolaryngology-Head and Neck Surgery)|제49권 제1호|pp. 79-84

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참고문헌

키워드

역류·후두염·호산구·식도·생검.Reflux·Laryngitis·Eosinophils·Esophagus·Biopsy.
주제분류이비인후과학

초록

Abstract

Background and Objectives：The reflux symptoms, laryngoscopic findings and 24-hour dual-probe pH monitoring are main diagnostic tools for laryngopharyngeal reflux disease. In particular, 24-hour dual-probe pH monitoring is the most specific and sensitive test, but some patients tend to fail the test due to discomfort. Eosinophilia in the esophageal mucosa may be diagnostic of gastroesophageal reflux disease, but esophageal biopsy has rarely been studied in laryngopharyngeal reflux. In this study, to discover another or alternative diagnostic tools that might help in the diagnosis of laryngopharyngeal reflux, we investigated the significance of esophageal mucosal biopsy in patients with laryngopharyngeal reflux symptoms. Subjects and Method：The study group consisted of 110 patients with laryngopharyngeal reflux symptoms and all patients were evaluated by 24 hour dual probe pH monitoring. The results of the 24 hour dual probe pH monitoring was compared with reflux symptom index (RSI),reflux finding score (RFS), gastroesophagoscopic findings, esophagogram and esophageal mucosal biopsy. Results：In 61 of the 110 patients, laryngopharyngeal reflux were confirmed by 24 hour dual probe pH monitoring. The mean RSI and RFS of thelaryngopharyngeal reflux group was higher (7.3±2.5, 6.0±3.9) than those of the group without laryngopharyngeal reflux (6.3±3.5, 4.6±2.9). Intraepithelial eosinophils in proximal esophageal biopsy was correlated with laryngopharyngeal reflux by 24- hour dual-probe pH monitoring. Conclusion：Esophageal mucosal biopsy is a reliable diagnostic test for laryngopharyngeal reflux and it could be used for patients who tend to fail 24-hour dual-probe pH monitoring due to discomfort. (Korean J Otolaryngol 2006;49:79-84)

참고문헌 (20)

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관련 논문AI추천

인후두 역류증의 미세구조 및 분자 수준의 특성우정수대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2009 · 제52권 제5호인후두역류증의 진단이윤세, 이진춘대한이비인후과학회 부산,울산,경남 지부회 · 임상이비인후과2009 · 제20권 제1호인후두역류증의 병태생리학주형로대한이비인후과학회 부산,울산,경남 지부회 · 임상이비인후과2009 · 제20권 제1호인후두 역류 질환 환자에서 선별 검사로서의 식도조영술의 유용성김명찬, 류동수, 윤준식, 이상준, 정용원, 정필상대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2004 · 제47권 제8호인후두역류증의 치료태경, 이용섭대한이비인후과학회 부산,울산,경남 지부회 · 임상이비인후과2009 · 제20권 제1호인후두 역류질환의 최근 경향이상혁, 허세형대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2011 · 제54권 제8호

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