상악동 후비공 비용과 비용에서의Matrix Metalloproteinase-2/-9의 발현
Expression of Matrix Metalloproteinase-2/-9 in Nasal Polyp and Antrochoanal Polyp
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Abstract
Background and Objectives：Nasal polyp (NP) and antrochoanal polyp (ACP) are soft tissue masses, featuring chronic inflammationand tissue remodeling. To elucidate the mechanism of tissue remodeling, we investigated the expressions of matrixmetalloproteinase-2 (MMP-2) and MMP-9 in ACP and NP and compared them with normal inferior turbinate mucosa. Subjectsand Method：Nasal samples, obtained from controls (n=10), from ACP (n=10) and from NP (n=13), were analysed byimmunohistochemistry. MMP-2/-9 expression was identified in epithelial, endothelial, gland, inflammatory cells. We assessedMMP-2/-9 immunoreactivity of ACP and NP in comparison with the normal inferior turbinate. The number of immunostainedinflammatory cells were determined. Results：In ACP, compared with controls, the MMP-2 expression was increased in vesselendothelium, while the MMP-9 expression was increased in vessel endothelium and inflammatory cells. In NP, compared withcontrols, increased expression of MMP-9 was observed in gland and inflammatory cells. Conclusion：ACP showed increasedexpression of MMP-2/-9, while NP showed increased expression of MMP-9. It is concluded that MMP-2/-9 in ACP and MMP-9in NP may play a role in tissue remodeling. (Korean J Otolaryngol 2006;49:786-90)
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