흡입화상환자에서 기관 내 점막의 병리조직학적 변화

Abstract

Background and Objectives：Inhalation injuries can produce a wide spectrum of negative clinical efects. Respiratory failure re-mains one of the leading causes of death in burned patients with inhalation injury. Despite advances in understanding of inhalation injury, few studies have focused on histopathologic findings of tracheal mucosa. The purpose of this study is to investigate histo-Subjects and Method：Tracheotomy was per-formed on 31 patients who was admitted to the Hospital center from May 205 to March 206. Thirty-one patients were divided into two groups：patients with inhalation injury (group I)(n= 16), patients without inhalation injury (group II)(n= 15). Tracheal mucosa were taken out during the tracheotomy. The tracheal mucosa were read blindly by one pathologist. Results：Histopatho-：epithelial ulceration. Diferent findings were observed in the group I as time pased by after inhalation injury, such as interstial edema, inflamatory cell infiltration, capillary dilatation, and increased fibrosis. No abnormal findings were observed in the tracheal mucosa in the group II. Conclusion：Inhalation injuries cause histopathologic damages to tracheal mucosa. The diferent histopathologic findings of tracheal mucosa that take place in time following inhalation injuries sugest to proces an inflamatory reaction. The study in (Korean J Otolaryngol 2007 ;50 :438-41)