두경부에 발생한 중복암에 대한 임상적 고찰 70예
Multiple Primary Malignancies in the Head and Neck：A Clinical Review of 70 Patients
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Abstract
Background and Objectives：Recent advances in medical management, along with increased life span, have contributed to the increased oportunity for detecting multiple primary malignancy (MPM)and clinical characteristics of MPM in the head and neck region. Subjects and Method：We reviewed retrospectively the med-ical records of 984 patients with malignant tumors of head and neck who had been diagnosed histopathologicaly and treated be-tween August 1985 to July 2005. Results：Seventy patients (7.11%) were diagnosed as having MPM (double, n= 66；triple, n= 4). This group consisted of 67 men and 3 women (p<0.01). Twenty-five patients (36% ) had synchronous double primary malig-nancy (SDPM) and 45 patients (64% ) had metachronous double primary malignancy (MDPM). The hypopharynx was the most fre-quently involved site of the index tumor. The most common index tumors were squamous cell carcinoma histopathologically. Second primary malignancies were found in esophagus, stomach and lung. Fifty-five patients were found with first primary ma-lignancy in head and neck, and 25 were with second primary malignancy. The patients with first and second primary malignancy (average of survival 11.1 months) was very por. Patients with MPM have high cigaretes smoking and alcohol drinking habit. Conclusion：Patients with head and neck malignancies will require care-ful folow up for prevention, early detection, and the treatment of second primary malignancy. (Korean J Otorhinolaryngol Head Neck Surg 2007 ;50 :694-8)
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