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나선 신경절의 생존

Survival of Spiral Ganglion

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초록

Survival and regeneration of spiral ganglion neuron (SGN) following deafening carries critical implication for cochlear implantation as well as reinnervation of restored hair cells. Survival and development of SGN depend on neurotrophic factors supplied by hair cells glial cells and other targets. The membrane electrical activity of spiral ganglion neurons also support their survival. Cell death inhibitors can also preserve spiral ganglion neurons. Recent studies of spiral ganglion survival including stem cell transplantation have identified several neurotrophic factors which protect neurons from death following hair cell loss. Although these experimental results are still preliminary, progression in study of strategy for SGN survival should be an important part of future neurobiology.

Abstract

Survival and regeneration of spiral ganglion neuron (SGN) following deafening carries critical implication for cochlear implantation as well as reinnervation of restored hair cells. Survival and development of SGN depend on neurotrophic factors supplied by hair cells glial cells and other targets. The membrane electrical activity of spiral ganglion neurons also support their survival. Cell death inhibitors can also preserve spiral ganglion neurons. Recent studies of spiral ganglion survival including stem cell transplantation have identified several neurotrophic factors which protect neurons from death following hair cell loss. Although these experimental results are still preliminary, progression in study of strategy for SGN survival should be an important part of future neurobiology.

참고문헌 (35)

  1. Doyle KJ, "Auditory neuropathy in childhood", Laryngoscope, 108(9), pp.1374~1377 (1998)
  2. Miyamoto RT, "Cochlear implantation in auditory neuropathy", Laryngoscope, 109(2), pp.181~185 (1999)
  3. Rubinstein JT, "How cochlear implants encode speech", Curr Opin Oto laryngol Head Neck Surg, 12(5), pp.444~448 (2004)
  4. Khan AM, "Is word recognition correlated with the number of surviving spiral ganglion cells and electrode insertion depth in human subjects with cochlear implants?", Laryngoscope, 115(4), pp.672~677 (2005)
  5. Spoendlin H, "Retrograde degeneration of the cochlear nerve", Acta Otolaryngol, 79(3), pp.266~275 (1975)
  6. Webster M, "Spiral ganglion neuron loss following organ of Corti loss: a quantitative study", Brain Res, 212(1), pp.17~30 (1981)
  7. Dodson HC, "Response of spiral ganglion neurones to cochlear hair cell destruction in the guinea pig", J Neurocytol, 29(7), pp.525~537 (2000)
  8. Bichler E, "Degeneration of cochlear neurons after amikacin intoxication in the rat", Arch Otorhinolaryngol, 237(3), pp.201~208 (1983)
  9. Zimmermann CE, "Patterns of degeneration in the human cochlear nerve", Hear Res, 90(1), pp.192~201 (1995)
  10. Huang EJ, "Trk receptors: roles in neuronal signal transduction", Annu Rev Biochem, (72), pp.609~642 (2003)
  11. Fritzsch B, "The role of neurotrophic factors in regulating the development of inner ear innervation", Trends Neurosci, 20(4), pp.159~164 (1997)
  12. Ylikoski J, "Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma", Hear Res, 124(1), pp.17~26 (1998)
  13. Staecker H, "NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants", Neuroreport, 6(11), pp.1533~1537 (1995)
  14. Kuang R, "Glial cell line-derived neurotrophic factor. Potential for otoprotection", Ann N Y Acad Sci, (884), pp.270~291 (1999)
  15. Hansen MR, "Reciprocal signaling between spiral ganglion neurons and Schwann cells involves neuregulin and neurotrophins", Hear Res, 161(1), pp.87~98 (2001)
  16. Hansen MR, "Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro", J Neurosci, 21(7), pp.2256~2267 (2001)
  17. Stankovic K, "Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear", J Neurosci, 24(40), pp.8651~8661 (2004)
  18. Kanzaki S, "Glial cell line-derived neurotrophic factor and chronic electrical stimulation prevent VIII cranial nerve degeneration following denervation", J Comp Neurol, 454(3), pp.350~360 (2002)
  19. Shepherd RK, "Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss", J Comp Neurol, 486(2), pp.145~158 (2005)
  20. Miller AL, "Mechanism of electrical stimulation-induced neuroprotection: effects of verapamil on protection of primary auditory afferents", Brain Res, 966(2), pp.218~230 (2003)
  21. Bok J, "An extranuclear locus of cAMPdependent protein kinase action is necessary and sufficient for promotion of spiral ganglion neuronal survival by cAMP", J Neurosci, 23(3), pp.777~787 (2003)
  22. Lefebvre PP, "Mechanisms of cell death in the injured auditory system: otoprotective strategies", Audiol Neurootol, 7(3), pp.165~170 (2002)
  23. Cheng AG, "Calpain inhibitors protect auditory sensory cells from hypoxia and neurotrophin-withdrawal induced apoptosis", Brain Res, 850(1), pp.234~243 (1999)
  24. Waetzig V, "The bright side of JNKs-Multitalented mediators in neuronal sprouting, brain development and nerve fiber regeneration", Prog Neurobiol, 80(2), pp.84~97 (2006)
  25. Bodmer D, "Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro", Laryngoscope, 112(11), pp.2057~2061 (2002)
  26. Guan QH, "The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia", reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways, 2005, pp.1035(1), 51~59
  27. Ohinata Y, "Glutathione limits noise-induced hearing loss", Hear Res, 146(1), pp.28~34 (2000)
  28. Hoffer ME, "Sustained-release devices in inner ear medical therapy", Otolaryngol Clin North Am, 37(5), pp.1053~1060 (2004)
  29. Bianchi LM, "Methods for providing therapeutic agents to treat damaged spiral ganglion neurons", Curr Drug Targets CNS Neurol Disord, 3(3), pp.195~199 (2004)
  30. Pettingill LN, "Neurotrophic factors and neural prostheses: potential clinical applications based upon findings in the auditory system", IEEE Trans Biomed Eng, 54(6), pp.1138~1148 (2007)
  31. Gonçalves MA, "A concise peer into the background, initial thoughts and practices of human gene therapy", Bioessays, 27(5), pp.506~517 (2005)
  32. Staecker H, "Gene expression in the mammalian cochlea: a study of multiple vector systems", Acta Otolaryngol, 121(2), pp.157~163 (2001)
  33. Lalwani AK, "In vitro and in vivo assessment of the ability of adeno-associated virus-brainderived neurotrophic factor to enhance spiral ganglion cell survival following ototoxic insult", Laryngoscope, 112(8), pp.1325~1334 (2002)
  34. Tamura T, "Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin", Acta Otolaryngol Suppl, (551), pp.65~68 (2004)
  35. Olivius P, "A model for implanting neuronal tissue into the cochlea", Brain Res Brain Res Protoc, 12(3), pp.152~156 (2004)

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