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내전형 연축성 발성장애 환자의 보툴리눔 독소-A 주입술 전후의 음성특성 비교

Voice Characteristics of Adductor Spasmodic Dysphonia before and after Botulinum Toxin-A Injection

최예린|최홍식|김향희|윤보람
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2011.02|대한이비인후과학회지 두경부외과학 (Korean Journal of Otorhinolaryngology-Head and Neck Surgery)|제54권 제02호|pp. 148-153

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참고문헌

주제분류이비인후과학

초록

Background and Objectives Botulinum toxin type A (BTX-A) injection is well known for its effectiveness in the treatment of “Spasmodic dysphonia”. However, studies on the efficacy of BTX-A injection have not been attempted in Korea. Therefore, this study was carried out to investigate the effects of BTX-A. Subjects and Method The study examined 12 female patients with ‘adductor spasmodic dysphonia’. Objective assesments included aerodynamic analysis and electoroglottography (EGG) of each patient before and after BTX-A. Subjective assessments included using the Korean-version of Voice Handicap Index-30 (KVHI-30) and a patient self-rating scale. Results Aerodynamic analysis revealed that only maximum phonation time (MPT) was significantly shortened after the injection of BTX-A (p<0.05). In the EGG, the mean frequ-ency distribution was significantly increased, while the mean amplitude and the mean clos-ed quotient distribution were significantly decreased (p<0.05). The KVHI-30 and patient self-rating scale scores were significantly decreased (p<0.01) as well, demonstrating the effects of BTX-A on the quality of life. Conclusion Our results show the effects of BTX-A objectively by comparing voice characteristics, which were measured through EGG before and after BTX-A injection, as well as by determining aerodynamic characteristics. The subjective self-assessment on the quality of life is significant as it may serve as a clinically relevant measure. This study may be helpful in elucidating treatment efficacy of BTX-A in many ways.

Abstract

Background and Objectives Botulinum toxin type A (BTX-A) injection is well known for its effectiveness in the treatment of “Spasmodic dysphonia”. However, studies on the efficacy of BTX-A injection have not been attempted in Korea. Therefore, this study was carried out to investigate the effects of BTX-A. Subjects and Method The study examined 12 female patients with ‘adductor spasmodic dysphonia’. Objective assesments included aerodynamic analysis and electoroglottography (EGG) of each patient before and after BTX-A. Subjective assessments included using the Korean-version of Voice Handicap Index-30 (KVHI-30) and a patient self-rating scale. Results Aerodynamic analysis revealed that only maximum phonation time (MPT) was significantly shortened after the injection of BTX-A (p<0.05). In the EGG, the mean frequ-ency distribution was significantly increased, while the mean amplitude and the mean clos-ed quotient distribution were significantly decreased (p<0.05). The KVHI-30 and patient self-rating scale scores were significantly decreased (p<0.01) as well, demonstrating the effects of BTX-A on the quality of life. Conclusion Our results show the effects of BTX-A objectively by comparing voice characteristics, which were measured through EGG before and after BTX-A injection, as well as by determining aerodynamic characteristics. The subjective self-assessment on the quality of life is significant as it may serve as a clinically relevant measure. This study may be helpful in elucidating treatment efficacy of BTX-A in many ways.

참고문헌 (24)

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