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소아 알레르기 질환의 발생과 면역치료

Development of Airway Allergic Diseases and Immunotherapy in Children

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참고문헌

주제분류이비인후과학

초록

Allergic march is a part of a phase that occurs in a series of continuous steps in disease of pediatricpatients, which proceeds from atopic dermatitis to asthma, and from asthma to allergic rhinitis. Recently, several hypotheses have been raised to explain the allergic march. Among them,the study of the hygiene theory related to microbiota, and the study on the role of innate cytokineswhich occurs in skin barrier damage are attracting attentions. If the interaction betweenthe microbiota and the immune system occurs improperly, the activity of the regulatory T cellbecomes insufficient and the immune-regulatory function is reduced, resulting in allergic diseases. Because of the skin barrier disruption, the innate cytokines are activated, thus resultingin Th2 inflammation reaction being increased. Considering this pathogenesis, blocking thelinkage to pathogens is regarded to play an important role in preventing and treating allergicmarch.

Abstract

Allergic march is a part of a phase that occurs in a series of continuous steps in disease of pediatricpatients, which proceeds from atopic dermatitis to asthma, and from asthma to allergic rhinitis. Recently, several hypotheses have been raised to explain the allergic march. Among them,the study of the hygiene theory related to microbiota, and the study on the role of innate cytokineswhich occurs in skin barrier damage are attracting attentions. If the interaction betweenthe microbiota and the immune system occurs improperly, the activity of the regulatory T cellbecomes insufficient and the immune-regulatory function is reduced, resulting in allergic diseases. Because of the skin barrier disruption, the innate cytokines are activated, thus resultingin Th2 inflammation reaction being increased. Considering this pathogenesis, blocking thelinkage to pathogens is regarded to play an important role in preventing and treating allergicmarch.

참고문헌 (66)

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