3차원 생체모사체 제작의 최신지견
Recent Advances in Three-Dimensional Multicellular Spheroid Formation for Biomedical Research
1
조회
0
다운로드
1
인용
0
참고문헌
초록
Multicellular spheroids (MCSs) from three dimensional culture, which is a complex architecturalstructure with dynamic cell to cell and cell to matrix interactions, mimic real tissues regardingstructural and functional properties. MCSs have emerged as an effective tool for fillingup the gap between the in vitro and in vivo experimental model and can replace the in vivomodel. The viability and functional performance can be enhanced when cells are grown as multicellularspheroid (MCS). In this review paper, we discussed the basic mechanism of MCSformation, their biomedical applications, and recent advances in MCS culture and tissue engineering.
Abstract
Multicellular spheroids (MCSs) from three dimensional culture, which is a complex architecturalstructure with dynamic cell to cell and cell to matrix interactions, mimic real tissues regardingstructural and functional properties. MCSs have emerged as an effective tool for fillingup the gap between the in vitro and in vivo experimental model and can replace the in vivomodel. The viability and functional performance can be enhanced when cells are grown as multicellularspheroid (MCS). In this review paper, we discussed the basic mechanism of MCSformation, their biomedical applications, and recent advances in MCS culture and tissue engineering.
참고문헌 (42)
- Fatehullah A, "Organoids as an in vitro model of human development and disease", Nat Cell Biol, 18(3), pp.246~254 (2016)
- Cui X, "Advances in multicellular spheroids formation", J R Soc Interface, 14(127), pp.20160877~ (2017)
- Lin RZ, "Dynamic analysis of hepatoma spheroid formation : Roles of E-cadherin and beta1-integrin", Cell Tissue Res, 324(3), pp.411~422 (2006)
- Narayanan RA, "Differential gene expression analysis during porcine hepatocyte spheroid formation", Mamm Genome, 13(9), pp.515~523 (2002)
- De Witt Hamer PC, "The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids", Oncogene, 27(14), pp.2091~2096 (2008)
- Kunz-Schughart LA, "The use of 3-D cultures for high-throughput screening : The multicellular spheroid model", J Biomol Screen, 9(4), pp.273~285 (2004)
- Weaver VM, "beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium", Cancer Cell, 2(3), pp.205~216 (2002)
- Debnath J, "The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini", Cell, 111(1), pp.29~40 (2002)
- Korff T, "Blood vessel maturation in a 3-dimensional spheroidal coculture model: Direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness", FASEB J, 15(2), pp.447~457 (2001)
- Kelm JM, "Design of artificial myocardial microtissues", Tissue Eng, 10(1-2), pp.201~214 (2004)
- Mironov V, "Organ printing: Computer-aided jet-based 3D tissue engineering", Trends Biotechnol, 21(4), pp.157~161 (2003)
- Kelm JM, "Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types", Biotechnol Bioeng, 83(2), pp.173~180 (2003)
- Kelm JM, "Microscale tissue engineering using gravity-enforced cell assembly", Trends Biotechnol, 22(4), pp.195~202 (2004)
- de Ridder L, "Autologous spheroid culture: A screening tool for human brain tumour invasion", Crit Rev Oncol Hematol, 36(2-3), pp.107~122 (2000)
- Wartenberg M, "Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells", FASEB J, 15(6), pp.995~1005 (2001)
- Yuhas JM, "A simplified method for production and growth of multicellular tumor spheroids", Cancer Res, 37(10), pp.3639~3643 (1977)
- Hamilton GA, "Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolayers", In Vitro Cell Dev Biol Anim, 37(10), pp.656~667 (2001)
- Wu LY, "Microfluidic self-assembly of tumor spheroids for anticancer drug discovery", Biomed Microdevices, 10(2), pp.197~202 (2008)
- Napolitano AP, "Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels", Tissue Eng, 13(8), pp.2087~2094 (2007)
- Dean DM, "Rods, tori, and honeycombs: The directed self-assembly of microtissues with prescribed microscale geometries", FASEB J, 21(14), pp.4005~4012 (2007)
- Karp JM, "Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells", Lab Chip, 7(6), pp.786~794 (2007)
- Khademhosseini A, "Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment", J Biomed Mater Res A, 79(3), pp.522~532 (2006)
- Fukuda J, "Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures", Biomaterials, 27(30), pp.5259~5267 (2006)
- Nyberg SL, "Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver", Liver Transpl, 11(8), pp.901~910 (2005)
- Song H, "Spatial composition of prostate cancer spheroids in mixed and static cultures", Tissue Eng, 10(7-8), pp.1266~1276 (2004)
- Ingram M, "Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor", In Vitro Cell Dev Biol Anim, 33(6), pp.459~466 (1997)
- Unsworth BR, "Growing tissues in microgravity", Nat Med, 4(8), pp.901~907 (1998)
- Du Y, "Identification and characterization of a novel prespheroid 3-dimensional hepatocyte monolayer on galactosylated substratum", Tissue Eng, 13(7), pp.1455~1468 (2007)
- Lu HF, "Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance", Biomaterials, 24(27), pp.4893~4903 (2003)
- Takezawa T, "Cell culture on a thermoresponsive polymer surface", Biotechnology(NY), 8(9), pp.854~856 (1990)
- Takezawa T, "Characterization of morphology and cellular metabolism during the spheroid formation by fibroblasts", Exp Cell Res, 208(2), pp.430~441 (1993)
- Ueno K, "Formation of multicellular spheroids composed of rat hepatocytes", Res Commun Chem Pathol Pharmacol, 77(1), pp.107~120 (1992)
- Elkayam T, "Enhancing the drug metabolism activities of C3A--a human hepatocyte cell line--by tissue engineering within alginate scaffolds", Tissue Eng, 12(5), pp.1357~1368 (2006)
- Lin KH, "Long-term maintenance of liver-specific functions in three-dimensional culture of adult rat hepatocytes with a porous gelatin sponge support", Biotechnol Appl Biochem, 21(1), pp.19~27 (1995)
- Akiyama M, "Periosteal cell pellet culture system: A new technique for bone engineering", Cell Transplant, 15(6), pp.521~532 (2006)
- Sebastian A, "Tissue engineering with electric fields: Immobilization of mammalian cells in multilayer aggregates using dielectrophoresis", Biotechnol Bioeng, 98(3), pp.694~700 (2007)
- Ino K, "Cell patterning using magnetite nanoparticles and magnetic force", Biotechnol Bioeng, 97(5), pp.1309~1317 (2007)
- Torisawa YS, "A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip", Biomaterials, 28(3), pp.559~566 (2007)
- Mohr JC, "3-D microwell culture of human embryonic stem cells", Biomaterials, 27(36), pp.6032~6042 (2006)
- Louie AY, "In vivo visualization of gene expression using magnetic resonance imaging", Nat Biotechnol, 18(3), pp.321~325 (2000)
- Santini MT, "Temporal dynamics of 1H-NMR-visible metabolites during radiation-induced apoptosis in MG-63 human osteosarcoma spheroids", Radiat Res, 166(5), pp.734~745 (2006)
- Huang S, "Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study", BMC Med Imaging, 8, pp.3~ (2008)
