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두경부암에서 MicroRNA의 진단적 및 치료적 역할

The Role of MicroRNA in Head and Neck Cancer

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주제분류이비인후과학

초록

Head and neck squamous cell carcinoma (HNSCC) include epithelial tumors arising in thestructures of aerodigestive tract such as oral and nasal cavity, pharynx, larynx, paranasal sinuses,and local lymph nodes. HNSCC is the sixth most common cancer worldwide, and itsprognosis is very poor. MicroRNAs (miRNAs) are small single stranded noncoding RNAswhich are about 19-25 nucleotides involved in cell proliferation, development, differentiationand metastasis. It is believed that miRNA alterations correlate with initiation and progressionof cancer cell proliferation or inhibition of tumorigenesis especially in development, progression,and metastasis of HNSCC. Altered expression of miRNAs could be novel molecular biomarkersfor the diagnosis and prognosis of HNSCC. Despite the advances in cancer treatment,the mortality rate of HNSCC is still high. The potential application of miRNAs for cancertherapy has been demonstrated in many studies. In this review, we discuss the very recentstudies on different aspects of miRNA dysregulation with their clinical significance and miRNA-based therapy.

Abstract

Head and neck squamous cell carcinoma (HNSCC) include epithelial tumors arising in thestructures of aerodigestive tract such as oral and nasal cavity, pharynx, larynx, paranasal sinuses,and local lymph nodes. HNSCC is the sixth most common cancer worldwide, and itsprognosis is very poor. MicroRNAs (miRNAs) are small single stranded noncoding RNAswhich are about 19-25 nucleotides involved in cell proliferation, development, differentiationand metastasis. It is believed that miRNA alterations correlate with initiation and progressionof cancer cell proliferation or inhibition of tumorigenesis especially in development, progression,and metastasis of HNSCC. Altered expression of miRNAs could be novel molecular biomarkersfor the diagnosis and prognosis of HNSCC. Despite the advances in cancer treatment,the mortality rate of HNSCC is still high. The potential application of miRNAs for cancertherapy has been demonstrated in many studies. In this review, we discuss the very recentstudies on different aspects of miRNA dysregulation with their clinical significance and miRNA-based therapy.

참고문헌 (56)

  1. Liu X, "MicroRNA profiling and head and neck cancer", Comp Funct Genomics, 2009, pp.837514~ (2009)
  2. Gomes CC, "MicroRNA and oral cancer : Future perspectives", Oral Oncol, 44(10), pp.910~914 (2008)
  3. Calin GA, "A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia", N Engl J Med, 353(17), pp.1793~1801 (2005)
  4. Urbich C, "Role of microRNAs in vascular diseases, inflammation, and angiogenesis", Cardiovasc Res, 79(4), pp.581~588 (2008)
  5. Severino P, "MicroRNA expression profile in head and neck cancer : HOX-cluster embedded microRNA-196a and microRNA-10b dysregulation implicated in cell proliferation", BMC Cancer, 13, pp.533~ (2013)
  6. Lu YC, "Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling", Cancer Prev Res(Phila), 5(4), pp.665~674 (2012)
  7. Reis PP, "Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma", Mol Cancer, 9, pp.238~ (2010)
  8. Li J, "MiR-21indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor", Clin Cancer Res, 15(12), pp.3998~4008 (2009)
  9. Hedbäck N, "MiR-21 expression in the tumor stroma of oral squamous cell carcinoma : An independent biomarker of disease free survival", PLoS One, 9(4), pp.e95193~ (2014)
  10. Liu CJ, "miR-31ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma", Cancer Res, 70(4), pp.1635~1644 (2010)
  11. Li G, "Increased expression of miR-93 is associated with poor prognosis in head and neck squamous cell carcinoma", Tumour Biol, 36(5), pp.3949~3956 (2015)
  12. Fang L, "MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8", Oncogene, 30(7), pp.806~821 (2011)
  13. Ni YH, "Upregulation of a potential prognostic biomarker, miR-155, enhances cell proliferation in patients with oral squamous cell carcinoma", Oral Surg Oral Med Oral Pathol Oral Radiol, 117(2), pp.227~233 (2014)
  14. Baba O, "MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis", J Oral Pathol Med, 45(4), pp.248~255 (2016)
  15. Lajer CB, "Different miRNA signatures of oral and pharyngeal squamous cell carcinomas : A prospective translational study", Br J Cancer, 104(5), pp.830~840 (2011)
  16. Cervigne NK, "Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma", Hum Mol Genet, 18(24), pp.4818~4829 (2009)
  17. Chu TH, "miR-211promotes the progression of head and neck carcinomas by targeting TGFβRII", Cancer Lett, 337(1), pp.115~124 (2013)
  18. Chang KW, "Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma", J Dent Res, 87(11), pp.1063~1068 (2008)
  19. Chen Z, "Downregulation of the microRNA-99 family members in head and neck squamous cell carcinoma", Oral Oncol, 48(8), pp.686~691 (2012)
  20. Nohata N, "miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma", Oncotarget, 2(1-2), pp.29~42 (2011)
  21. Johnson SM, "RAS is regulated by the let-7 microRNA family", Cell, 120(5), pp.635~647 (2005)
  22. Chang CJ, "Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer", Oncol Rep, 26(4), pp.1003~1010 (2011)
  23. Childs G, "Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma", Am J Pathol, 174(3), pp.736~745 (2009)
  24. Chang CC, "MicroRNA-17", 20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma, 2013, pp.49(9), 923~931
  25. Kinoshita T, "Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma", Br J Cancer, 109(10), pp.2636~2645 (2013)
  26. Roderburg C, "Micro-RNA profiling reveals a role for miR-29in human and murine liver fibrosis", Hepatology, 53(1), pp.209~218 (2011)
  27. Siemens H, "miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions", Cell Cycle, 10(24), pp.4256~4271 (2011)
  28. Chen D, "MicroRNA deregulations in head and neck squamous cell carcinomas", J Oral Maxillofac Res, 4(1), pp.e2~ (2013)
  29. Xu N, "MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion", J Biol Chem, 287(35), pp.29899~29908 (2012)
  30. Chen YF, "miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A", Redox Biol, 22, pp.101140~ (2019)
  31. Sasahira T, "Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer", Br J Cancer, 107(4), pp.700~706 (2012)
  32. Kinoshita T, "Tumor suppressive microRNA-133a regulates novel targets : Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma", Biochem Biophys Res Commun, 418(2), pp.378~383 (2012)
  33. Jiang L, "Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2(GNAI2)as a microRNA-138 target in tongue squamous cell carcinoma", Hum Genet, 129(2), pp.189~197 (2011)
  34. Liu X, "MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines", Biochem J, 440(1), pp.23~31 (2011)
  35. Xu Q, "Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer", Carcinogenesis, 34(3), pp.539~549 (2013)
  36. Tamagawa S, "Role of miR-200c", miR-141 in the regulation of epithelialmesenchymal transition and migration in head and neck squamous cell carcinoma, 2014, pp.33(4), 879~886
  37. Lo WL, "MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells", J Pathol, 223(4), pp.482~495 (2011)
  38. Liu X, "MicroRNA-222regulates cell invasion by targeting matrix metalloproteinase 1(MMP1)and manganese superoxide dismutase 2(SOD2)in tongue squamous cell carcinoma cell lines", Cancer Genomics Proteomics, 6(3), pp.131~139 (2009)
  39. Sun Q, "Dysregulated miR-363 affects head and neck cancer invasion and metastasis by targeting podoplanin", Int J Biochem Cell Biol, 45(3), pp.513~520 (2013)
  40. Harris T, "Low-level expression of miR-375 correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas", Am J Pathol, 180(3), pp.917~928 (2012)
  41. Siow MY, "Dysregulation of miR-31 and miR-375expression is associated with clinical outcomes in oral carcinoma", Oral Dis, 20(4), pp.345~351 (2014)
  42. Park NJ, "Salivary microRNA: Discovery, characterization, and clinical utility for oral cancer detection", Clin Cancer Res, 15(17), pp.5473~5477 (2009)
  43. Avissar M, "MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma", Clin Cancer Res, 15(8), pp.2850~2855 (2009)
  44. Barker EV, "microRNA evaluation of unknown primary lesions in the head and neck", Mol Cancer, 8, pp.127~ (2009)
  45. Fletcher AM, "Detection of metastatic head and neck squamous cell carcinoma using the relative expression of tissue-specific mir-205", Transl Oncol, 1(4), pp.202~208 (2008)
  46. Santhi WS, "Oncogenic microRNAs as biomarkers of oral tumorigenesis and minimal residual disease", Oral Oncol, 49(6), pp.567~575 (2013)
  47. Luo XJ, "Distinguishable prognostic miRNA signatures of head and neck squamous cell cancer with or without HPV infection", Front Oncol, 10, pp.614487~ (2020)
  48. Lajer CB, "The role of miRNAs in human papilloma virus(HPV)-associated cancers : Bridging between HPV-related head and neck cancer and cervical cancer", Br J Cancer, 117(5), pp.e2~ (2017)
  49. Tong F, "HPV +HNSCC-derived exosomal miR-9 induces macrophage M1polarization and increases tumor radiosensitivity", Cancer Lett, 478, pp.34~44 (2020)
  50. Iorio MV, "MicroRNA dysregulation in cancer:Diagnostics, monitoring and therapeutics. A comprehensive review", EMBO Mol Med, 4(3), pp.143~159 (2012)
  51. Ebert MS, "MicroRNA sponges : Competitive inhibitors of small RNAs in mammalian cells", Nat Methods, 4(9), pp.721~726 (2007)
  52. Bader AG, "The promise of microRNA replacement therapy", Cancer Res, 70(18), pp.7027~7030 (2010)
  53. Rather MI, "Oncogenic microRNA-155 down-regulates tumor suppressor CDC73and promotes oral squamous cell carcinoma cell proliferation : Implications for cancer therapeutics", J Biol Chem, 288(1), pp.608~618 (2013)
  54. Janssen HL, "Treatment of HCV infection by targeting microRNA", N Engl J Med, 368(18), pp.1685~1694 (2013)
  55. Yan B, "Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells", Mol Med Rep, 6(3), pp.675~681 (2012)
  56. Choi WY, "Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430", Science, 318(5848), pp.271~274 (2007)

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