Association between Elevated Pleural Interleukin-33 Levels and Tuberculous Pleurisy
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Background: Interferon-γ (IFN-γ) plays a crucial role in Mycobacterium tuberculosis induced pleural responses. Interleukin (IL)-33 up-regulates the production of IFN-γ. We aimed to identify whether an association between pleural IL-33 levels and tuberculous pleurisy exists and determine its diagnostic value. Methods: Pleural IL-33, ST2 (a receptor of IL-33), adenosine deaminase (ADA), and IFN-γ, as well as serum IL-33 and ST2 were measured in 220 patients with pleural effusions (PEs). Patients with malignant (MPEs), parapneumonic (PPEs), tuberculous (TPEs), and cardiogenic (CPEs) pleural effusions were included. Results: Pleural and serum IL-33 levels were highest or tended to be higher in patients with TPEs than in those with other types of PEs. The median pleural fluid-to-serum IL-33ratio was higher in TPE cases (≥ 0.91) than in other PE cases (≤ 0.56). Pleural IL-33 levels correlated with those of pleural ADA and IFN-γ. However, the diagnostic accuracies of pleural IL-33 (0.74) and pleural fluid-to-serum IL-33 ratio (0.75) were lower than that of ADA (0.95) or IFN-γ (0.97). Pleural ST2 levels in patients with MPEs were higher than in patients with TPEs. Serum ST2 levels did not differ among the groups. Conclusions: We identified an association between elevated pleural IL-33 levels and tuberculous pleurisy. However, we recommend conventional pleural markers (ADA or IFN-γ) as diagnostic markers of TPE.
Abstract
Background: Interferon-γ (IFN-γ) plays a crucial role in Mycobacterium tuberculosis induced pleural responses. Interleukin (IL)-33 up-regulates the production of IFN-γ. We aimed to identify whether an association between pleural IL-33 levels and tuberculous pleurisy exists and determine its diagnostic value. Methods: Pleural IL-33, ST2 (a receptor of IL-33), adenosine deaminase (ADA), and IFN-γ, as well as serum IL-33 and ST2 were measured in 220 patients with pleural effusions (PEs). Patients with malignant (MPEs), parapneumonic (PPEs), tuberculous (TPEs), and cardiogenic (CPEs) pleural effusions were included. Results: Pleural and serum IL-33 levels were highest or tended to be higher in patients with TPEs than in those with other types of PEs. The median pleural fluid-to-serum IL-33ratio was higher in TPE cases (≥ 0.91) than in other PE cases (≤ 0.56). Pleural IL-33 levels correlated with those of pleural ADA and IFN-γ. However, the diagnostic accuracies of pleural IL-33 (0.74) and pleural fluid-to-serum IL-33 ratio (0.75) were lower than that of ADA (0.95) or IFN-γ (0.97). Pleural ST2 levels in patients with MPEs were higher than in patients with TPEs. Serum ST2 levels did not differ among the groups. Conclusions: We identified an association between elevated pleural IL-33 levels and tuberculous pleurisy. However, we recommend conventional pleural markers (ADA or IFN-γ) as diagnostic markers of TPE.
참고문헌 (36)
- Caramori G, "Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy", PLoS One, 6, pp.22637~ (2011)
- Baumann MH, "Pleural tuberculosis in the United States: incidence and drug resistance", Chest, 131, pp.1125~1132 (2007)
- Sahn SA, "State of the art. The pleura", Am Rev Respir Dis, 138, pp.184~234 (1988)
- Sneller MC, "Granuloma formation, implications for the pathogenesis of vasculitis", Cleve Clin J Med, 69(S2), pp.S40~S43 (2002)
- Sada-Ovalle I, "Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria", PLoS Pathog, 4, pp.e1000239~ (2008)
- Schierloh P, "Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy", Infect Immun, 75, pp.5325~5337 (2007)
- Feng CG, "NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis", J Immunol, 177, pp.7086~7093 (2006)
- Orme IM, "Cytokine", chemokine cascades in immunity to tuberculosis, 1999, pp.20, 307~312
- Pasquinelli V, "IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB", J Infect Dis, 199, pp.661~665 (2009)
- Asano M, "Endogenous gamma interferon is essential in granuloma formation induced by glycolipid-containing mycolic acid in mice", Infect Immun, 61, pp.2872~2878 (1993)
- van Crevel R, "Innate immunity to Mycobacterium tuberculosis", Clin Microbiol Rev, 15, pp.294~309 (2002)
- Schmitz J, "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor- related protein ST2 and induces T helper type 2-associated cytokines", Immunity, 23, pp.479~490 (2005)
- Bourgeois E, "The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production", Eur J Immunol, 39, pp.1046~1055 (2009)
- Smith DE, "IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma", Clin Exp Allergy, 40, pp.200~208 (2010)
- Préfontaine D, "Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells", J Immunol, 183, pp.5094~5103 (2009)
- Masamune A, "Nuclear expression of interleukin-33 in pancreatic stellate cells", Am J Physiol Gastrointest Liver Physiol, 299, pp.G821~G832 (2010)
- Wood IS, "IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes", Biochem Biophys Res Commun, 384, pp.105~109 (2009)
- Wong CF, "Assay of pleural fluid interleukin-6, tumour necrosis factor-alpha and interferon- gamma in the diagnosis and outcome correlation of tuberculous effusion", Respir Med, 97, pp.1289~1295 (2003)
- Orphanidou D, "Tumour necrosis factor, interleukin-1 and adenosine deaminase in tuberculous pleural effusion", Respir Med, 90, pp.95~98 (1996)
- Barnes PF, "Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis", J Immunol, 145, pp.149~154 (1990)
- Espinassous Q, "IL-33 enhances lipopolysaccharideinduced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex", J Immunol, 183, pp.1446~1455 (2009)
- Xu D, "IL-33 exacerbates antigen-induced arthritis by activating mast cells", Proc Natl Acad Sci U S A, 105, pp.10913~10918 (2008)
- Smithgall MD, "IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells", Int Immunol, 20, pp.1019~1030 (2008)
- Cooper AM, "Interleukin-12 and tuberculosis: an old story revisited", Curr Opin Immunol, 19, pp.441~447 (2007)
- Valdés L, "Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions", Eur Respir J, 33, pp.816~820 (2009)
- Oshikawa K, "Expression of ST2 in helper T lymphocytes of malignant pleural effusions", Am J Respir Crit Care Med, 165, pp.1005~1009 (2002)
- Okamoto M, "T-helper type 1", T-helper type 2 balance in malignant pleural effusions compared to tuberculous pleural effusions, 2005, pp.128, 4030~4035
- Aoe K, "Diagnostic significance of interferon-gamma in tuberculous pleural effusions", Chest, 123, pp.740~744 (2003)
- Greco S, "Adenosine deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: a meta-analysis", Int J Tuberc Lung Dis, 7, pp.777~786 (2003)
- Boonyagars L, "Use of adenosine deaminase for the diagnosis of tuberculosis: a review", J Infect Dis Antimicrob Agents, 27, pp.111~118 (2010)
- Light RW, "Pleural effusions: the diagnostic separation of transudates and exudates", Ann Intern Med, 77, pp.507~513 (1972)
- Oboki K, "IL-33 and IL-33 receptors in host defense and diseases", Allergol Int, 59, pp.143~160 (2010)
- Miller AM, "Role of IL-33 in inflammation and disease", J Inflamm, 8, pp.22~ (2011)
- Chen YM, "Cross regulation by IL-10 and IL-2", IL-12 of the helper T cells and the cytolytic activity of lymphocytes from malignant effusions of lung cancer patients, 1997, pp.112, 960~966
- Moussion C, "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel ‘alarmin’?", PLoS One, 3, pp.e3331~ (2008)
- Joshi AD, "Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages", BMC Immunol, 11, pp.52~ (2010)
