Fatal Pulmonary Mucormycosis Caused by Rhizopus microsporus in a Patient with Diabetes
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Mucormycosis is an opportunistic infection caused by fungi of the order Mucorales, environmental nonseptate molds widely distributed in soil, plants, and decaying materials [1]. Mucormy- cosis can be divided into the following categories on the basis of the site of infection: rhinocerebral, pulmonary, cutaneous, and disseminated [2-4]. The most common clinical presentation is rhinocerebral disease, followed by pulmonary infection. Medically important Mucorales are Lichtheimia, Absidia, Mu- cor, Rhizomucor, Rhizopus, Cunninghamella , and Syncephalas- trum . Identification of Mucorales is primarily based on standard mycological methods. However, culture-based identification is often difficult and time-consuming. Conventional phenotypic methods usually identify isolates only to the genus level, and sometimes only as Mucorales. In recent years, internal tran- scribed spacer (ITS) sequencing has been applied to fungi and is considered a reliable method for the accurate identification of most pathogenic Mucorales to the species level [5]. However, a few species have high ITS sequence homology, making their differentiation difficult.
Abstract
Mucormycosis is an opportunistic infection caused by fungi of the order Mucorales, environmental nonseptate molds widely distributed in soil, plants, and decaying materials [1]. Mucormy- cosis can be divided into the following categories on the basis of the site of infection: rhinocerebral, pulmonary, cutaneous, and disseminated [2-4]. The most common clinical presentation is rhinocerebral disease, followed by pulmonary infection. Medically important Mucorales are Lichtheimia, Absidia, Mu- cor, Rhizomucor, Rhizopus, Cunninghamella , and Syncephalas- trum . Identification of Mucorales is primarily based on standard mycological methods. However, culture-based identification is often difficult and time-consuming. Conventional phenotypic methods usually identify isolates only to the genus level, and sometimes only as Mucorales. In recent years, internal tran- scribed spacer (ITS) sequencing has been applied to fungi and is considered a reliable method for the accurate identification of most pathogenic Mucorales to the species level [5]. However, a few species have high ITS sequence homology, making their differentiation difficult.
참고문헌 (13)
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