Serious Adverse Transfusion Reactions Reported in the National Recipient-Triggered Trace Back System in Korea (2006-2014)
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초록
Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.
Abstract
Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.
참고문헌 (25)
- Ji Eun Cho, "National blood management system and the direction of government policy in Korea", Blood Research, 45(2), pp.81~83 (2010), 대한혈액학회
- 김신영, "Performance review of the National Blood Safety Improvement Project in Korea (2004‒2009)", Blood Research, 48(2), pp.139~144 (2013), 대한혈액학회
- Andreu G, "Hemovigilance network in France: organization and analysis of immediate transfusion incident reports from 1994 to 1998", Transfusion, 42, pp.1356~1364 (2002)
- McClelland B, "Haemovigilance: concept, Europe and UK initiatives", VoxSang, 74(S2), pp.S431~S439 (1998)
- Menitove JE, "Hemovigilance in the United States of America", Vox Sang, 74(S2), pp.S447~S455 (1998)
- Keller-Stanislawski B, "The German Haemovigilance System--reports of serious adverse transfusion reactions between 1997 and 2007", Transfus Med, 19, pp.340~349 (2009)
- Otsubo H, "Current risks in blood transfusion in Japan", Jpn J Infect Dis, 61, pp.427~433 (2008)
- Faber JC, "Review of the main haemovigilance systems in the world", Transfus Clin Biol, 16, pp.86~92 (2009)
- "Definition Look Back and Trace Back January 2015 Page 1 of 1"[URL]
- Kim MJ, "Residual risk of transfusion-transmitted infection with human immunodeficiency virus, hepatitis C virus, and hepatitis B virus in Korea from 2000 through 2010", BMC Infect Dis, 12, pp.160~ (2012)
- Zou S, "Current incidence and residual risk of hepatitis B infection among blood donors in the United States", Transfusion, 49, pp.1609~1620 (2009)
- Brant LJ, "Hepatitis B and residual risk of infection in English and Welsh blood donors, 1996 through 2008", Transfusion, 51, pp.1493~1502 (2011)
- Moiz B, "Estimating window period blood donations for human immunodeficiency virus Type 1, hepatitis C virus, and hepatitis B virus by nucleic acid amplification testing in Southern Pakistan", Transfusion, 54, pp.1652~1659 (2014)
- Feighner BH, "Reemergence of Plasmodium vivax malaria in the republic of Korea", Emerg Infect Dis, 4, pp.295~297 (1998)
- Seo DH, "Analysis of blood donation history of Korean malaria patients", Korean J Clin Pathol, 19, pp.569~571 (1999)
- Korean Society of Blood Transfusion, "The recommendation of standard blood bank and blood center service", pp.69~ (2007), Medrang Inforang
- Purdy E, "Transfusion-transmitted malaria: unpreventable by current donor exclusion guidelines?", Transfusion, 44, pp.464~ (2004)
- World malaria report 2014, "World Health Organization", WHO, ~ (2014)
- 조한익, "대한수혈학회 창립 30주년을 기념하며", 대한수혈학회지, 23(2), pp.97~106 (2012), 대한수혈학회
- Fatalities reported to FDA following blood collection and transfusion: annual summary for fiscal year 2012, "US Food and Drug Administration", US Food and Drug Administration, ~ (2014)
- Eder AF, "Bacterial screening of apheresis platelets and the residual risk of septic transfusion reactions: the American Red Cross experience (2004-2006)", Transfusion, 47, pp.1134~1142 (2007)
- Stainsby D, "Serious hazards of transfusion: a decade of hemovigilance in the UK", Transf Med Rev, 20, pp.273~282 (2006)
- Fujii Y, "Consecutive national surveys of ABO-incompatible blood transfusion in Japan", Vox Sang, 97, pp.240~246 (2009)
- Myhre BA, "Human error-a significant cause of transfusion mortality", Transfusion, 40, pp.879~885 (2000)
- 진선미, "A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia", Blood Research, 47(4), pp.302~306 (2012), 대한혈액학회