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Use of Repetitive Transcranial Magnetic Stimulation for Treatment in Psychiatry

André Aleman
대한정신약물학회 (Korean College of Neuropsychopharmacology)|2013.08|Clinical Psychopharmacology and Neuroscience|제11권 제2호|pp. 53-59

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참고문헌

키워드

DepressionSchizophreniaTranscranial magnetic stimulationHallucinationsPrefrontal cortex.

초록

The potential of noninvasive neurostimulation by repetitive transcranial magnetic stimulation (rTMS) for improving psychiatric disorders has been studied increasingly over the past two decades. This is especially the case for major depression and for auditory-verbal hallucinations in schizophrenia. The present review briefly describes the background of this novel treatment modality and summarizes evidence from clinical trials into the efficacy of rTMS for depression and hallucinations. Evidence for efficacy in depression is stronger than for hallucinations, although a number of studies have reported clinically relevant improvements for hallucinations too. Different stimulation parameters (frequency, duration, location of stimulation) are discussed. There is a paucity of research into other psychiatric disorders, but initial evidence suggests that rTMS may also hold promise for the treatment of negative symptoms in schizophrenia, obsessive compulsive disorder and post-traumatic stress disorder. It can be concluded that rTMS induces alterations in neural networks relevant for psychiatric disorders and that more research is needed to elucidate efficacy and underlying mechanisms of action.

Abstract

The potential of noninvasive neurostimulation by repetitive transcranial magnetic stimulation (rTMS) for improving psychiatric disorders has been studied increasingly over the past two decades. This is especially the case for major depression and for auditory-verbal hallucinations in schizophrenia. The present review briefly describes the background of this novel treatment modality and summarizes evidence from clinical trials into the efficacy of rTMS for depression and hallucinations. Evidence for efficacy in depression is stronger than for hallucinations, although a number of studies have reported clinically relevant improvements for hallucinations too. Different stimulation parameters (frequency, duration, location of stimulation) are discussed. There is a paucity of research into other psychiatric disorders, but initial evidence suggests that rTMS may also hold promise for the treatment of negative symptoms in schizophrenia, obsessive compulsive disorder and post-traumatic stress disorder. It can be concluded that rTMS induces alterations in neural networks relevant for psychiatric disorders and that more research is needed to elucidate efficacy and underlying mechanisms of action.

참고문헌 (58)

  1. George MS, "Daily left prefrontal repetitive transcranial magnetic stimulation for acute treatment of medication- resistant depression", Am J Psychiatry, 168, pp.356~364 (2011)
  2. Slotema CW, "Should we expand the toolbox of psychiatric treatment methods to include Repetitive Transcranial Magnetic Stimulation (rTMS)? A meta-analysis of the efficacy of rTMS in psychiatric disorders", J Clin Psychiatry, 71, pp.873~884 (2010)
  3. Matheson SL, "Quality assessment and comparison of evidence for electroconvulsive therapy and repetitive transcranial magnetic stimulation for schizophrenia: a systematic meta-review", Schizophr Res, 118, pp.201~210 (2010)
  4. Barker AT, "Non-invasive magnetic stimulation of human motor cortex", Lancet, 325, pp.1106~1107 (1985)
  5. Sack AT, "Transcranial magnetic stimulation, causal structure- function mapping and networks of functional relevance", Curr Opin Neurobiol, 16, pp.593~599 (2006)
  6. Hallett M, "Transcranial magnetic stimulation and the human brain", Nature, 406, pp.147~150 (2000)
  7. Siebner HR, "Continuous transcranial magnetic stimulation during positron emission tomography: a suitable tool for imaging regional excitability of the human cortex", Neuroimage, 14, pp.883~890 (2001)
  8. Speer AM, "Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients", Biol Psychiatry, 48, pp.1133~1141 (2000)
  9. Keck ME, "Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system", Neuropharmacology, 43, pp.101~109 (2002)
  10. Strafella AP, "Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus", J Neurosci, 21, pp.RC157~ (2001)
  11. Cho SS, "rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex", PLoS One, 4, pp.e6725~ (2009)
  12. Wassermann EM, "Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroencephalogr", Clin Neurophysiol, 108, pp.1~16 (1998)
  13. Rossi S, "Safety of TMS Consensus Group. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research", Clin Neurophysiol, 120, pp.2008~2039 (2009)
  14. Phillips ML, "Neurobiology of emotion perception II: Implications for major psychiatric disorders", Biol Psychiatry, 54, pp.515~528 (2003)
  15. Sackeim HA, "Regional cerebral blood flow in mood disorders. I. Comparison of major depressives and normal controls at rest", Arch Gen Psychiatry, 47, pp.60~70 (1990)
  16. Martinot JL, "Left prefrontal glucose hypometabolism in the depressed state: a confirmation", Am J Psychiatry, 147, pp.1313~1317 (1990)
  17. Elliott R, "Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography", Psychol Med, 27, pp.931~942 (1997)
  18. Barrett J, "Mechanisms of action underlying the effect of repetitive transcranial magnetic stimulation on mood: behavioral and brain imaging studies", Neuropsychopharmacology, 29, pp.1172~1189 (2004)
  19. Schutter DJ, "Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis", Psychol Med, 39, pp.65~75 (2009)
  20. Dell'osso B, "Meta-review of metanalytic studies with repetitive transcranial magnetic stimulation (rTMS) for the treatment of major depression", Clin Pract Epidemiol Ment Health, 7, pp.167~177 (2011)
  21. Berlim MT, "Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and shamcontrolled trials", Psychol Med (2013)
  22. Berlim MT, "Clinically meaningful efficacy and acceptability of low-frequency repetitive transcranial magnetic stimulation (rTMS) for treating primary major depression: a meta-analysis of randomized, double-blind and sham-controlled trials", Neuropsychopharmacology, 38, pp.543~551 (2013)
  23. George MS, "Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial", Arch Gen Psychiatry, 67, pp.507~516 (2010)
  24. Hoffman RE, "Transcranial magnetic stimulation and auditory hallucinations in schizophrenia", Lancet, 355, pp.1073~1075 (2000)
  25. Hoffman RE, "Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations", Arch Gen Psychiatry, 60, pp.49~56 (2003)
  26. Hoffman RE, "Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample", Biol Psychiatry, 58, pp.97~104 (2005)
  27. Silbersweig DA, "A functional neuroanatomy of hallucinations in schizophrenia", Nature, 378, pp.176~179 (1995)
  28. Shergill SS, "Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging", Arch Gen Psychiatry, 57, pp.1033~1038 (2000)
  29. Allen P, "The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations", Neurosci Biobehav Rev, 32, pp.175~191 (2008)
  30. Aleman A, "Efficacy of slow repetitive transcranial magnetic stimulation in the treatment of resistant auditory hallucinations in schizophrenia: a metaanalysis", J Clin Psychiatry, 68, pp.416~421 (2007)
  31. Poulet E, "Slow transcranial magnetic stimulation can rapidly reduce resistant auditory hallucinations in schizophrenia", Biol Psychiatry, 57, pp.188~191 (2005)
  32. Brunelin J, "Low frequency repetitive transcranial magnetic stimulation improves source monitoring deficit in hallucinating patients with schizophrenia", Schizophr Res, 81, pp.41~45 (2006)
  33. McIntosh AM, "Transcranial magnetic stimulation for auditory hallucinations in schizophrenia", Psychiatry Res, 127, pp.9~17 (2004)
  34. Fitzgerald PB, "A double-blind sham-controlled trial of repetitive transcranial magnetic stimulation in the treatment of refractory auditory hallucinations", J Clin Psychopharmacol, 25, pp.358~362 (2005)
  35. Vercammen A, "Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial", Schizophr Res, 114, pp.172~179 (2009)
  36. Slotema CW, "Can low-frequency repetitive transcranial magnetic stimulation really relieve medicationresistant auditory verbal hallucinations? Negative results from a large randomized controlled trial", Biol Psychiatry, 69, pp.450~456 (2011)
  37. Blumberger DM, "MRI-targeted repetitive transcranial magnetic stimulation of Heschl's gyrus for refractory auditory hallucinations", Brain Stimul, 5, pp.577~585 (2012)
  38. Slotema CW, "Meta-analysis of repetitive transcranial magnetic stimulation in the treatment of auditory verbal hallucinations: update and effects after one month", Schizophr Res, 142, pp.40~45 (2012)
  39. Lennox BR, "The functional anatomy of auditory hallucinations in schizophrenia", Psychiatry Res, 100, pp.13~20 (2000)
  40. Jandl M, "Treating auditory hallucinations by transcranial magnetic stimulation: a randomized controlled cross-over trial", Neuropsychobiology, 53, pp.63~69 (2006)
  41. Lee SH, "A double blind study showing that two weeks of daily repetitive TMS over the left or right temporoparietal cortex reduces symptoms in patients with schizophrenia who are having treatment-refractory auditory hallucinations", Neurosci Lett, 376, pp.177~181 (2005)
  42. Cook ND, "The brain code; mechanisms of information transfer and the role of the corpus callosum" (1986), Methuen
  43. Fitzgerald PB, "A randomized, controlled trial of sequential bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression", Am J Psychiatry, 163, pp.88~94 (2006)
  44. Montagne-Larmurier A, "Two-day treatment of auditory hallucinations by high frequency rTMS guided by cerebral imaging: a 6 month follow-up pilot study", Schizophr Res, 113, pp.77~83 (2009)
  45. Johnson KA, "Prefrontal rTMS for treating depression: location and intensity results from the OPT-TMS multi-site clinical trial", Brain Stimul, 6, pp.108~117 (2013)
  46. Rusjan PM, "Optimal transcranial magnetic stimulation coil placement for targeting the dorsolateral prefrontal cortex using novel magnetic resonance image-guided neuronavigation", Hum Brain Mapp, 31, pp.1643~1652 (2010)
  47. Schönfeldt-Lecuona C, "The value of neuronavigated rTMS for the treatment of depression", Neurophysiol Clin, 40, pp.37~43 (2010)
  48. Trojak B, "Further evidence of the usefulness of MRI-based neuronavigation for the treatment of depression by rTMS", J Neuropsychiatry Clin Neurosci, 23, pp.E30~E31 (2011)
  49. Hoffman RE, "Probing the pathophysiology of auditory", verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation, 2007, pp.17, 2733~2743
  50. Sommer IE, "Can fMRI-guidance improve the efficacy of rTMS treatment for auditory verbal hallucinations?", Schizophr Res, 93, pp.406~408 (2007)
  51. Schönfeldt-Lecuona C, "Stereotaxic rTMS for the treatment of auditory hallucinations in schizophrenia", Neuroreport, 15, pp.1669~1673 (2004)
  52. Gross M, "Has repetitive transcranial magnetic stimulation (rTMS) treatment for depression improved? A systematic review and meta-analysis comparing the recent vs. the earlier rTMS studies", Acta Psychiatr Scand, 116, pp.165~173 (2007)
  53. Dlabac-de Lange JJ, "Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: review and meta-analysis", J Clin Psychiatry, 71, pp.411~418 (2010)
  54. Jaafari N, "Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder: a review", World J Biol Psychiatry, 13, pp.164~177 (2012)
  55. Gomes PV, "A randomized, double-blind trial of repetitive transcranial magnetic stimulation in obsessive-compulsive disorder with three-month follow-up", J Neuropsychiatry Clin Neurosci, 24, pp.437~443 (2012)
  56. Watts BV, "A sham controlled study of repetitive transcranial magnetic stimulation for posttraumatic stress disorder", Brain Stimul, 5, pp.38~43 (2012)
  57. Brunoni AR, "Placebo response of non-pharmacological and pharmacological trials in major depression: a systematic review and meta-analysis", PLoS One, 4, pp.e4824~ (2009)
  58. Broadbent HJ, "Blinding success of rTMS applied to the dorsolateral prefrontal cortex in randomised shamcontrolled trials: a systematic review", World J Biol Psychiatry, 12, pp.240~248 (2011)

관련 논문AI추천

The Efficacy of Miniaturized Repetitive Transcranial Magnetic Stimulation in Patients with DepressionJeong-Ho Chae, Kuk-In Jang, Sangmin Lee, Sejin Yoon대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제3호Predictors of Response to Repetitive Transcranial Magnetic Stimulation in Depression: A Review of Recent UpdatesSujita Kumar Kar대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제1호Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric ComorbidityAlexander T. Sack, Che-Sheng Chu, Hsin-An Chang, Kuan-Pin Su, Ming-Kuei Lu, Po-Han Chou, Taishiro Kishimoto, Wei Hung Chang, Yen-Feng Lin대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제2호Low-frequency, Repetitive Transcranial Magnetic Stimulation for the Treatment of Patients with Posttraumatic Stress Disorder: a Double-blind, Sham-controlled Study남동현, 배치운, 채정호대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2013 · 제11권 제2호Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations in Patients with Schizophrenia: A Randomized Controlled, Cross-over Study김은지, 김형태, 김홍매, 박종일, 여성욱, 정영철, 황인호, 황태영, Yin Cui대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2014 · 제12권 제3호Transcranial Electrical Stimulation: Clinical Implication and Practice for Treatment of Psychiatric IllnessBori Jung, Chaeyeon Yang, Seung-Hwan Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2024 · 제22권 제3호

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