Empathy and Social Attribution Skills Moderate the Relationship between Temporal Lobe Volume and Facial Expression Recognition Ability in Schizophrenia
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Objective: While impaired facial expression recognition has been closely associated with reduced temporal lobe volume in patients with schizophrenia, this study aimed at examining whether empathy and social attribution affect such a relationship. Methods: A total of 43 patients with schizophrenia and 43 healthy controls underwent a facial expression recognition task (FERT) and magnetic resonance imaging. Basic empathy scale and the social attribution task-multiple choice were used to measure empathy and social attribution. Results: Patients with schizophrenia showed significant positive correlations between the total temporal lobe volume and the FERT-accuracy (FERT-ACC). Diminished temporal lobe volume predicted the impaired facial emotion recognition ability. Both empathy and social attribution played roles as moderators of the path from the left amygdala volume, left fusiform gyrus volume, both sides of the superior temporal gyrus volume, and left middle temporal gyrus volume to the FERT-ACC. In contrast, empathy alone functioned as a moderator between the right fusiform gyrus volume, right middle temporal gyrus volume, and FERT-ACC. No significant interaction was found for healthy controls. Conclusion: Our results suggest that social cognition remediation training on empathy and social attribution, could buffer the negative effects of small temporal lobe volume on interpersonal emotional communication in patients with schizophrenia.
Abstract
Objective: While impaired facial expression recognition has been closely associated with reduced temporal lobe volume in patients with schizophrenia, this study aimed at examining whether empathy and social attribution affect such a relationship. Methods: A total of 43 patients with schizophrenia and 43 healthy controls underwent a facial expression recognition task (FERT) and magnetic resonance imaging. Basic empathy scale and the social attribution task-multiple choice were used to measure empathy and social attribution. Results: Patients with schizophrenia showed significant positive correlations between the total temporal lobe volume and the FERT-accuracy (FERT-ACC). Diminished temporal lobe volume predicted the impaired facial emotion recognition ability. Both empathy and social attribution played roles as moderators of the path from the left amygdala volume, left fusiform gyrus volume, both sides of the superior temporal gyrus volume, and left middle temporal gyrus volume to the FERT-ACC. In contrast, empathy alone functioned as a moderator between the right fusiform gyrus volume, right middle temporal gyrus volume, and FERT-ACC. No significant interaction was found for healthy controls. Conclusion: Our results suggest that social cognition remediation training on empathy and social attribution, could buffer the negative effects of small temporal lobe volume on interpersonal emotional communication in patients with schizophrenia.
참고문헌 (80)
- Aas M, "A history of childhood trauma is associated with slower improvement rates : findings from a one-year follow-up study of patients with a first-episode psychosis", BMC Psychiatry, 16, pp.126~ (2016)
- Kohler CG, "Facial emotion recognition in schizophrenia : intensity effects and error pattern", Am J Psychiatry, 160, pp.1768~1774 (2003)
- Mandal MK, "Facial expressions of emotions and schizophrenia : a review", Schizophr Bull, 24, pp.399~412 (1998)
- Morrison RL, "Deficits in facial-affect recognition and schizophrenia", Schizophr Bull, 14, pp.67~83 (1988)
- Namiki C, "Impaired facial emotion recognition and reduced amygdalar volume in schizophrenia", Psychiatry Res, 156, pp.23~32 (2007)
- Sachs G, "Facial recognition deficits and cognition in schizophrenia", Schizophr Res, 68, pp.27~35 (2004)
- Wölwer W, "Facial affect recognition in the course of schizophrenia", Eur Arch Psychiatry Clin Neurosci, 246, pp.165~170 (1996)
- Shenton ME, "A review of MRI findings in schizophrenia", Schizophr Res, 49, pp.1~52 (2001)
- Wookyoung Jung, "Heart and Brain Interaction of Psychiatric Illness: A Review Focused on Heart Rate Variability, Cognitive Function, and Quantitative Electroencephalography", Clinical Psychopharmacology and Neuroscience, 17(4), pp.459~474 (2019), 대한정신약물학회[DOI]
- Hyeonjin Jeon, "From Neurons to Social Beings: Short Review of the Mirror Neuron System Research and Its Socio-Psychological and Psychiatric Implications", Clinical Psychopharmacology and Neuroscience, 16(1), pp.18~31 (2018), 대한정신약물학회[DOI]
- WonKyung Cho, "Biological Aspects of Aggression and Violence in Schizophrenia", Clinical Psychopharmacology and Neuroscience, 17(4), pp.475~486 (2019), 대한정신약물학회[DOI]
- Goghari VM, "Temporal lobe structures and facial emotion recognition in schizophrenia patients and nonpsychotic relatives", Schizophr Bull, 37, pp.1281~1294 (2011)
- Li H, "Facial emotion processing in schizophrenia : a meta-analysis of functional neuroimaging data", Schizophr Bull, 36, pp.1029~1039 (2010)
- Fried I, "Single neuron activity in human hippocampus and amygdala during recognition of faces and objects", Neuron, 18, pp.753~765 (1997)
- Adolphs R, "Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala", Nature, 372, pp.669~672 (1994)
- Armony JL, "Current emotion research in behavioral neuroscience : the role(s)of the amygdala", Emot Rev, 5, pp.104~115 (2013)
- Davidson RJ, "The functional neuroanatomy of emotion and affective style", Trends Cogn Sci, 3, pp.11~21 (1999)
- Haxby JV, "The distributed human neural system for face perception", Trends Cogn Sci, 4, pp.223~233 (2000)
- Furl N, "Modulation of perception and brain activity by predictable trajectories of facial expressions", Cereb Cortex, 20, pp.694~703 (2010)
- Peelen MV, "Emotional attention in acquired prosopagnosia", Soc Cogn Affect Neurosci, 4, pp.268~277 (2009)
- Trautmann SA, "Emotions in motion : dynamic compared to static facial expressions of disgust and happiness reveal more widespread emotion-specific activations", Brain Res, 1284, pp.100~115 (2009)
- Allison T, "Social perception from visual cues : role of the STS region", Trends Cogn Sci, 4, pp.267~278 (2000)
- Puce A, "Differential sensitivity of human visual cortex to faces, letterstrings, and textures : a functional magnetic resonance imaging study", J Neurosci, 16, pp.5205~5215 (1996)
- Steen RG, "Brain volume in first-episode schizophrenia : systematic review and meta-analysis of magnetic resonance imaging studies", Br J Psychiatry, 188, pp.510~518 (2006)
- Honea R, "Regional deficits in brain volume in schizophrenia : a meta-analysis of voxel-based morphometry studies", Am J Psychiatry, 162, pp.2233~2245 (2005)
- Kuroki N, "Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia : an MRI study", Am J Psychiatry, 163, pp.2103~2110 (2006)
- Lawrie SM, "Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies", Br J Psychiatry, 172, pp.110~120 (1998)
- Nelson MD, "Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging : a meta-analytic study", Arch Gen Psychiatry, 55, pp.433~440 (1998)
- Velakoulis D, "Hippocampal and amygdala volumes according to psychosis stage and diagnosis : a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals", Arch Gen Psychiatry, 63, pp.139~149 (2006)
- Wright IC, "Meta-analysis of regional brain volumes in schizophrenia", Am J Psychiatry, 157, pp.16~25 (2000)
- Kurtz MM, "Social cognitive training for schizophrenia : a meta-analytic investigation of controlled research", Schizophr Bull, 38, pp.1092~1104 (2012)
- Lee KH, "Social cognition, brain networks and schizophrenia", Psychol Med, 34, pp.391~400 (2004)
- Arioli M, "Social cognition through the lens of cognitive and clinical neuroscience", Biomed Res Int, 2018, pp.4283427~ (2018)
- Horat SK, "Impaired social cognition in schizophrenia during the ultimatum game : an EEG study", Schizophr Res, 192, pp.308~316 (2018)
- Sprong M, "Theory of mind in schizophrenia : meta-analysis", Br J Psychiatry, 191, pp.5~13 (2007)
- Marwick K, "Social cognition in schizophrenia : a review of face processing", Br Med Bull, 88, pp.43~58 (2008)
- Kosonogov V, "Empathy, but not mimicry restriction, influences the recognition of change in emotional facial expressions", Q J Exp Psychol(Hove), 68, pp.2106~2115 (2015)
- Brüne M, "Mental state attribution, neurocognitive functioning, and psychopathology:what predicts poor social competence in schizophrenia best?", Schizophr Res, 92, pp.151~159 (2007)
- Fitzpatrick P, "Relationship between theory of mind, emotion recognition, and social synchrony in adolescents with and without autism", Front Psychol, 9, pp.1337~ (2018)
- Olderbak S, "Emotion perception and empathy : an individual differences test of relations", Emotion, 17, pp.1092~1106 (2017)
- Lindenmayer JP, "Improving social cognition in schizophrenia : a pilot intervention combining computerized social cognition training with cognitive remediation", Schizophr Bull, 39, pp.507~517 (2013)
- Ashburner J, "Computational anatomy with the SPM software", Magn Reson Imaging, 27, pp.1163~1174 (2009)
- Ashburner J, "Voxel-based morphometry--the methods", Neuroimage, 11, pp.805~821 (2000)
- Ashburner J, "A fast diffeomorphic image registration algorithm", Neuroimage, 38, pp.95~113 (2007)
- Ashburner J, "Unified segmentation", Neuroimage, 26, pp.839~851 (2005)
- Jolliffe D, "Development and validation of the Basic Empathy Scale", J Adolesc, 29, pp.589~611 (2006)
- Heider F, "An experimental study of apparent behavior", Am J Psychol, 57, pp.243~259 (1944)
- Klin A, "Attributing social meaning to ambiguous visual stimuli in higher-functioning autism and Asperger syndrome : the social attribution task", J Child Psychol Psychiatry, 41, pp.831~846 (2000)
- Klin A, "Attributing social and physical meaning to ambiguous visual displays in individuals with higher-functioning autism spectrum disorders", Brain Cogn, 61, pp.40~53 (2006)
- Getz GE, "Facial affect recognition deficits in bipolar disorder", J Int Neuropsychol Soc, 9, pp.623~632 (2003)
- Korean Facial Expressions of Emotion(KOFEE), "Park JY", Section of Affect & Neuroscience, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, ~ (2011)
- Preacher KJ, "Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models", Behav Res Methods, 40, pp.879~891 (2008)
- Onitsuka T, "Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia", Arch Gen Psychiatry, 60, pp.349~355 (2003)
- Feinberg TE, "Facial discrimination and emotional recognition in schizophrenia and affective disorders", Arch Gen Psychiatry, 43, pp.276~279 (1986)
- Gur RC, "Brain activation during facial emotion processing", Neuroimage, 16, pp.651~662 (2002)
- Walker E, "Recognition and identification of facial stimuli by schizophrenics and patients with affective disorders", Br J Clin Psychol, 23, pp.37~44 (1984)
- Kim DW, "Source activation during facial emotion perception correlates with positive and negative symptoms scores of schizophrenia", Conf Proc IEEE Eng Med Biol Soc, 2013, pp.6325~6328 (2013)
- Lee SH, "Event-related potential patterns and gender effects underlying facial affect processing in schizophrenia patients", Neurosci Res, 67, pp.172~180 (2010)
- Aleman A, "Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia?", Prog Neurobiol, 77, pp.283~298 (2005)
- Kosaka H, "Differential amygdala response during facial recognition in patients with schizophrenia : an fMRI study", Schizophr Res, 57, pp.87~95 (2002)
- Exner C, "Impaired emotional learning and reduced amygdala size in schizophrenia : a 3-month follow-up", Schizophr Res, 71, pp.493~503 (2004)
- Lee JS, "Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia", Neuropsychiatr Dis Treat, 12, pp.1~14 (2015)
- Maat A, "Emotion recognition and theory of mind are related to gray matter volume of the prefrontal cortex in schizophrenia", Eur Neuropsychopharmacol, 26, pp.255~264 (2016)
- Baas D, "Lateralization of amygdala activation : a systematic review of functional neuroimaging studies", Brain Res Brain Res Rev, 45, pp.96~103 (2004)
- Canli T, "Event-related activation in the human amygdala associates with later memory for individual emotional experience", J Neurosci, 20, pp.RC99~ (2000)
- Hamann S, "Cognitive and neural mechanisms of emotional memory", Trends Cogn Sci, 5, pp.394~400 (2001)
- Hamann S, "Positive and negative emotional verbal stimuli elicit activity in the left amygdala", Neuroreport, 13, pp.15~19 (2002)
- Wager TD, "Valence, gender, and lateralization of functional brain anatomy in emotion : a meta-analysis of findings from neuroimaging", Neuroimage, 19, pp.513~531 (2003)
- Aggleton JP, "Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology", Neuropsychologia, 43, pp.1810~1823 (2005)
- Rugg MD, "Human recognition memory : a cognitive neuroscience perspective", Trends Cogn Sci, 7, pp.313~319 (2003)
- Yonelinas AP, "The nature of recollection and familiarity : a review of 30 years of research", J Mem Lang, 46, pp.441~517 (2002)
- Habel U, "Training of affect recognition in schizophrenia : Neurobiological correlates", Soc Neurosci, 5, pp.92~104 (2010)
- Luckhaus C, "Training of affect recognition in schizophrenia patients with violent offences : behavioral treatment effects and electrophysiological correlates", Soc Neurosci, 8, pp.505~514 (2013)
- Hooker CI, "The influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia", Psychiatry Res, 213, pp.99~107 (2013)
- Horan WP, "Social cognition training for individuals with schizophrenia : emerging evidence", Am J Psychiatr Rehabil, 11, pp.205~252 (2008)
- Popova P, "Changing facial affect recognition in schizophrenia : effects of training on brain dynamics", Neuroimage Clin, 6, pp.156~165 (2014)
- Silver H, "Brief emotion training improves recognition of facial emotions in chronic schizophrenia. A pilot study", Psychiatry Res, 128, pp.147~154 (2004)
- Wölwer W, "Social-cognitive remediation in schizophrenia : generalization of effects of the Training of Affect Recognition(TAR)", Schizophr Bull, 37(Suppl 2), pp.S63~S70 (2011)
- Wölwer W, "Remediation of impairments in facial affect recognition in schizophrenia : efficacy and specificity of a new training program", Schizophr Res, 80, pp.295~303 (2005)
- Kleinhans NM, "Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders", Neuropsychologia, 48, pp.3665~3670 (2010)
