A Different View on the Etiopathogenesis of Attention-deficit Hyperactivity Disorder from an Inflammation Perspective
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Objective: Attention-deficit hyperactivity disorder (ADHD) has a complex etiology and genetic, environmental and biological factors are considered to play a role in the etiology of ADHD by mutually interacting. Recent studies have emphasized that inflammation may be present in the etiology of ADHD. This study aims to investigate the possible role of visfatin, IL-6, IL-1 and TNF- molecules in the etiology of ADHD. Methods: The study included 60 patients and 20 healthy controls between the ages of 6−18. Serum visfatin, IL-6, IL-1 and TNF- levels were evaluated with enzyme-linked immunosorbent assay (ELISA) kits at a biochemistry laboratory. Results: The study showed no statistically significant difference between children with ADHD and healthy controls in terms of visfatin, IL-6, IL-1 and TNF- levels. When ADHD subgroups (combined and predominantly inattentive types) and the control group were compared in terms of visfatin, IL-6, IL-1 and TNF- levels, no statistically significant difference was recorded. Conclusion: Data on the relationship between ADHD and IL-6, IL-1 and TNF- in this study are in compliance with the literature. However, no study was found on visfatin in ADHD. This study is the first one evaluating the ADHD-Visfatin relationship.
Abstract
Objective: Attention-deficit hyperactivity disorder (ADHD) has a complex etiology and genetic, environmental and biological factors are considered to play a role in the etiology of ADHD by mutually interacting. Recent studies have emphasized that inflammation may be present in the etiology of ADHD. This study aims to investigate the possible role of visfatin, IL-6, IL-1 and TNF- molecules in the etiology of ADHD. Methods: The study included 60 patients and 20 healthy controls between the ages of 6−18. Serum visfatin, IL-6, IL-1 and TNF- levels were evaluated with enzyme-linked immunosorbent assay (ELISA) kits at a biochemistry laboratory. Results: The study showed no statistically significant difference between children with ADHD and healthy controls in terms of visfatin, IL-6, IL-1 and TNF- levels. When ADHD subgroups (combined and predominantly inattentive types) and the control group were compared in terms of visfatin, IL-6, IL-1 and TNF- levels, no statistically significant difference was recorded. Conclusion: Data on the relationship between ADHD and IL-6, IL-1 and TNF- in this study are in compliance with the literature. However, no study was found on visfatin in ADHD. This study is the first one evaluating the ADHD-Visfatin relationship.
참고문헌 (32)
- Faraone SV, "Molecular genetics of attention-defi-cit", hyperactivity disorder, 2005, pp.57, 1313~1323
- Percinel I, "Iron deficiency in the pathophysiology of attention deficit hyperactivity disorder", Current Approaches to Psychiatry, 7, pp.41~55 (2015)
- Leffa DT, "A review on the role of inflammation in attention-deficit", hyperactivity disorder, 2018, pp.25, 328~333
- Anand D, "Attentiondeficit", hyperactivity disorder and inflammation : what does current knowledge tell us? A systematic review, 2017, pp.8, 228~
- Segman RH, "Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder", Mol Psychiatry, 7, pp.72~74 (2002)
- Zalcman S, "Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and-6", Brain Res, 643, pp.40~49 (1994)
- Oades RD, "Attention-deficit hyperactivity disorder(ADHD)and glial integrity : S100B, cytokines and kynurenine metabolism--effects of medication", Behav Brain Funct, 6, pp.29~ (2010)
- Hunter CA, "IL-6 as a keystone cytokine in health and disease", Nat Immunol, 16, pp.448~457 (2015)
- Erta M, "Interleukin-6, a major cytokine in the central nervous system", Int J Biol Sci, 8, pp.1254~1266 (2012)
- Uzun G, "Visfatin and its effects", J Turk Clin Biochem, 11, pp.119~130 (2013)
- Wędrychowicz A, "Peptides from adipose tissue in mental disorders", World J Psychiatry, 4, pp.103~111 (2014)
- Darwish AH, "Serum interleukin-6level in children with attention-deficit hyperactivity disorder(ADHD)", J Child Neurol, 34, pp.61~67 (2019)
- Chang JP, "Cortisol, inflammatory biomarkers and neurotrophins in children and adolescents with attention deficit hyperactivity disorder(ADHD)in Taiwan", Brain Behav Immun, 88, pp.105~113 (2020)
- Xiang-Dong P, "Correlation between interleukin-1, interleukin-6, tumor necrosis factor-and attention deficit hyperactivity disorder", Matern Child Health Care China, 27, pp.370~373 (2012)
- Leffa DT, "Increased oxidative parameters and decreased cytokine levels in an animal model of attention-deficit", hyperactivity disorder, 2017, pp.42, 3084~3092
- Ghaffari MA, "Increased serum levels of tumor necrosis factor-alpha, resistin, and visfatin in the children with autism spectrum disorders : a case-control study", Neurol Res Int, 2016, pp.9060751~ (2016)
- Hedayati M, "Association between serum levels of visfatin and binge eating disorders in overweight women", Int J Rev Life Sci, 5, pp.838~841 (2015)
- Ziora K, "Assessment of serum visfatin levels in girls with anorexia nervosa", Clin Endocrinol(Oxf), 76, pp.514~519 (2012)
- Levin RL, "Attention-deficit", hyperactivity disorder and eating disorders across the lifespan : a systematic review of the literature, 2016, pp.50, 22~36
- Surman CB, "Association between attention-deficit", hyperactivity disorder and bulimia nervosa : analysis of 4 case-control studies, 2006, pp.67, 351~354
- Nazar BP, "The risk of eating disorders comorbid with attention-deficit", hyperactivity disorder : a systematic review and meta-analysis, 2016, pp.49, 1045~1057
- "Turk J Child Adolesc Ment Health", 2004, 109~116
- Mukaddes NM, "Yaşam Boyu Dikkat Eksikliği Hiperaktivite Bozukluğu ve Eşlik Eden Durumlar" (2015), Nobel Tip
- Misener VL, "Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit", hyperactivity disorder, 2004, pp.50, 231~234
- Verlaet AAJ, "Oxidative stress and immune aberrancies in attention-deficit", hyperactivity disorder(ADHD) : a case-control comparison, 2019, pp.28, 719~729
- Donfrancesco R, "Anti-Yo antibodies in children with ADHD : first results about serum cytokines", J Atten Disord, 24, pp.1497~1502 (2020)
- Corominas-Roso M, "IL-6 and TNF- in unmedicated adults with ADHD : relationship to cortisol awakening response", Psychoneuroendocrinology, 79, pp.67~73 (2017)
- Baranowska-Bik A, "Adipokine profile in patients with anorexia nervosa", Endokrynol Pol, 68, pp.422~429 (2017)
- Dostálová I, "Serum visfatin levels in patients with anorexia nervosa and bulimia nervosa", Physiol Res, 58, pp.903~907 (2009)
- Oades RD, "Attention-deficit hyperactivity disorder(ADHD)and glial integrity : an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention", Behav Brain Funct, 6, pp.32~ (2010)
- Genc S, "The relation of oxidative stress biomarkers with proinflammatory cytokines in gestational diabetes", Clin Investig, 7, pp.43~48 (2017)
- Karakoç S, "Relationship between adiponectin, interleukin-6 and tumour necrosis factor-alpha levels and body mass index change in obesity", Future Vis J, 3, pp.1~8 (2019)
