본문 바로가기
KERD
논문KCI 등재

Serum Galectin-3 Levels in Children with Attention-Deficit/Hyperactivity Disorder

Ümit Is¸ ık|Faruk Kılıç|Arif Demirdas¸|Evrim Aktepe|Pınar Aydog˘ an Avs¸ ar
대한신경정신의학회 (Korean Neuropsychiatric Association)|2020.03|PSYCHIATRY INVESTIGATION|제17권 제3호|pp. 256-261|DOI https://doi.org/10.30773/pi.2019.0247

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

Attention-deficit/hyperactivity disorderGalectin-3Inflammatory mediators.
주제분류정신과학

초록

Objective Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with underlying pathogenesis and etiological factors not fully understood. We assumed that galectin-3, which is also linked with inflammatory responses, may play an important role in the ethiopathogenesis of ADHD. In this study, we aimed to investigate whether serum galectin-3 levels are related to ADHD in childhood. Methods The current study consisted of 35 treatment-naive children with ADHD and 35 control subjects. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires. The severity of anxiety and depression symptoms of the children were determined by the self-report scale. Venous blood samples were collected and serum galectin-3 levels were measured. Results The ADHD group had significantly higher serum Galectin-3 levels than the control group. To control confounding factors, including age, sex, and BMI percentile, one-way analysis of covariance (ANCOVA) test was also performed. Analyses revealed a significantly higher serum log- Galectin-3 levels in children with ADHD compared to controls. No association was found between the mean serum galectin-3 levels and sociodemographic characteristics and clinical test scores, except the oppositional defiant behavior scores. Conclusion Our research supports the hypothesis that serum levels of galectin-3 might be related to ADHD.

Abstract

Objective Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with underlying pathogenesis and etiological factors not fully understood. We assumed that galectin-3, which is also linked with inflammatory responses, may play an important role in the ethiopathogenesis of ADHD. In this study, we aimed to investigate whether serum galectin-3 levels are related to ADHD in childhood. Methods The current study consisted of 35 treatment-naive children with ADHD and 35 control subjects. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires. The severity of anxiety and depression symptoms of the children were determined by the self-report scale. Venous blood samples were collected and serum galectin-3 levels were measured. Results The ADHD group had significantly higher serum Galectin-3 levels than the control group. To control confounding factors, including age, sex, and BMI percentile, one-way analysis of covariance (ANCOVA) test was also performed. Analyses revealed a significantly higher serum log- Galectin-3 levels in children with ADHD compared to controls. No association was found between the mean serum galectin-3 levels and sociodemographic characteristics and clinical test scores, except the oppositional defiant behavior scores. Conclusion Our research supports the hypothesis that serum levels of galectin-3 might be related to ADHD.

참고문헌 (36)

  1. American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition", American Psychiatric Association, ~ (2013)
  2. Willcutt EG, "The prevalence of DSM-IV attention-deficit", hyperactivity disorder : a meta-analytic review, 2012, pp.9, 490~499
  3. Thomas R, "Prevalence of attention-deficit", hyperactivity disorder : a systematic review and metaanalysis, 2015, pp.135, e994~e1001
  4. Ercan ES, "The prevalence of childhood psychopathology in Turkey : a cross-sectional multicenter nationwide study(EPICPAT-T)", Nord J Psychiatry, 73, pp.132~140 (2019)
  5. Thapar A, "Practitioner review: What have we learnt about the causes of ADHD?", J Child Psychol Psychiatry, 54, pp.3~16 (2013)
  6. Thapar A, "Attention deficit hyperactivity disorder", Lancet, 6736, pp.1~11 (2015)
  7. Faraone SV, "Biomarkers in the diagnosis of ADHD – promising directions", Curr Psychiatry Rep, 16, pp.497~ (2014)
  8. Dunn GA, "Neuroinflammation as a risk factor for attention deficit hyperactivity disorder", Pharmacol Biochem Behav, 182, pp.22~34 (2019)
  9. Anand D, "Attention-deficit", hyperactivity disorder and inflammation : what does current knowledge tell us? A systematic review, 2017, pp.8, 1~7
  10. Leffa DT, "A review on the role of nflammation in attention-deficit", hyperactivity disorder, 2018, pp.25, 328~333
  11. Donfrancesco R, "Anti-yo antibodies in children with ADHD", J Atten Disord, pp.1087054716643387~
  12. Barondes SH, "Galectins. Structure and function of a large family of animal lectins", J Biol Chem, 269, pp.20807~20810 (1994)
  13. Yang RY, "Galectins : structure, function and therapeutic potential", Expert Rev Mol Med, 10, pp.e17~ (2008)
  14. Dumic J, "Galectin-3 : an open-ended story", Biochim Biophys Acta, 1760, pp.616~635 (2006)
  15. Almkvist J, "Galectins as inflammatory mediators", Glycoconj J, 19, pp.575~581 (2002)
  16. Hsu DK, "Targeted disruption of the Galectin-3 gene results in attenuated peritoneal inflammatory responses", Am J Pathol, 156, pp.1073~1083 (2000)
  17. Venkatraman A, "Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites", Alzheimer’s Dement Transl Res Clin Interv, 4, pp.165~172 (2018)
  18. Doverhag C, "Galectin-3 contributes to neonatal hypoxic-ischemic brain injury", Neurobiol Dis, 38, pp.36~46 (2010)
  19. Rahimian R, "Galectin-3 : mediator of microglia responses in injured brain", Drug Discov Today, 23, pp.375~381 (2018)
  20. Kajitani K, "Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation", Psychopharmacology (Berl), 234, pp.2919~2927 (2017)
  21. Borovcanin MM, "IL-33", ST2 pathway and galectin-3 as a new analytes in pathogenesis and cardiometabolic risk evaluation in psychosis, 2018, pp.9, 271~
  22. Wu L, "A novel function of MicroRNA Let-7d in regulation of galectin-3 expression in attention deficit hyperactivity disorder rat brain", Brain Pathol, 20, pp.1042~1054 (2010)
  23. Wu LH, "Circulating MicroRNA Let-7d in attention-deficit", hyperactivity disorder, 2015, pp.17, 137~146
  24. Gökler B, "Reliability and validity of schedule for affective disorders and schizophrenia for school age children-present and lifetime version-Turkish version(K-SADS-PL-T)", Turkish J Child Adolesc Ment Heal, 11, pp.109~116 (2004)
  25. Kaufman J, "Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version(K-SADS-PL) : Initial reliability and validity data", J Am Acad Child Adolesc Psychiatry, 36, pp.980~988 (1997)
  26. "J Child Adolesc Ment Health", 2001, 132~144
  27. Turgay A, "Disruptive Behavior Disorders Child and Adolescent Screening and Rating Scales for Children, Adolescents, Parents and Teachers" (1994), Michigan Integrative Therapy Institute Publication
  28. Gormez V, "Psychometric properties of the Turkish version of the Revised Child Anxiety and Depression Scale-Child Version in a clinical sample", Psychiatry Clin Psychopharmacol, 27, pp.84~92 (2017)
  29. Filer A, "Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways", Arthritis Rheum, 60, pp.1604~1614 (2009)
  30. Boscher C, "Glycosylation, galectins and cellular signaling", Curr Opin Cell Biol, 23, pp.383~392 (2011)
  31. Yu F, "Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation", J Biol Chem, 277, pp.15819~15827 (2002)
  32. Darwish AH, "Serum interleukin-6 level in children with attention-deficit hyperactivity disorder(ADHD)", J Child Neurol, 34, pp.61~67 (2019)
  33. O’Shea TM, "Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants", Pediatr Res, 75, pp.781~787 (2014)
  34. Jiang HR, "Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis", J Immunol, 182, pp.1167~1173 (2009)
  35. Chen C, "Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium", Clin Cancer Res, 19, pp.1693~1704 (2013)
  36. Chen SS, "Downregulating galectin-3 inhibits proinflammatory cytokine production by human monocyte-derived dendritic cells via RNA interference", Cell Immunol, 294, pp.44~53 (2015)

이 간행물의 다른 논문 (11건)

Major Depressive Disorder: Current Advances and Paradigm ShiftsYong-Ku Kimpp. 179-180Ketamine in Major Depressive Disorder: Mechanisms and Future Perspectives김용구, 신민철pp. 181-192Personalized Psychiatry and Depression: The Role of Sociodemographic and Clinical VariablesGiampaolo Perna, Alessandra Alciati, Silvia Daccò, Massimiliano Grassi, Daniela Caldirolapp. 193-206Understanding the Complex of Suicide in Depression: from Research to ClinicsAlessandro Valchera, Maurizio Pompili, Giovanni Martinotti, Silvia Fraticelli, Roberto Latini, Carmine Tomasetti, Raffaella La Rovere, Domenico De Berardis, Gianluca Serafini, Laura Orsolini, Umberto Volpe, Michele Fornaro, Sabatino Trotta, Federica Vellante, Marco Alessandrini, Massimo Di Giannantoniopp. 207-221The Hypothesis on the Prediction of Treatment Response with Buspirone Augmentation along with Serotonergic Antidepressant in Patients with Major Depressive Disorder Using Loudness Dependence of Auditory Evoked Potentials: Two Cases and Review of the Literature for EvidenceYoung-Min Parkpp. 222-224
원문 보기