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Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports

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초록

COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events. However, the healthcare workers (HCWs) have paid the higher price of this pandemic in terms of fatalities, contagions, and psychological well-being. Studies suggest that this particular population is at increased risk of developing a severe post-traumatic stress disorder (PTSD). The early diagnosis and timely treatment of PTSD in HCWs may restore well-being and significantly impact health services functioning, reducing burnout, days spent far from work, disrupted personal and team empowerment, and worse job performances. In the present article, we reported on two cases of HCWs directly involved in the treatment of COVID-19 patients who showed selective serotonin reuptake inhibitor-resistant PTSD, which was successfully treated with extended- release trazodone TRZ ContramidⓇ add-on.

Abstract

COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events. However, the healthcare workers (HCWs) have paid the higher price of this pandemic in terms of fatalities, contagions, and psychological well-being. Studies suggest that this particular population is at increased risk of developing a severe post-traumatic stress disorder (PTSD). The early diagnosis and timely treatment of PTSD in HCWs may restore well-being and significantly impact health services functioning, reducing burnout, days spent far from work, disrupted personal and team empowerment, and worse job performances. In the present article, we reported on two cases of HCWs directly involved in the treatment of COVID-19 patients who showed selective serotonin reuptake inhibitor-resistant PTSD, which was successfully treated with extended- release trazodone TRZ ContramidⓇ add-on.

참고문헌 (42)

  1. Giallonardo V, "The impact of quarantine and physical distancing following COVID-19 on mental health : study protocol of a multicentric Italian population trial", Front Psychiatry, 11, pp.533~ (2020)
  2. Adiukwu F, "Global perspective and ways to combat stigma associated with COVID-19", Indian J Psychol Med, 42, pp.569~574 (2020)
  3. Horesh D, "Traumatic stress in the age of COVID-19 : a call to close critical gaps and adapt to new realities", Psychol Trauma, 12, pp.331~335 (2020)
  4. Raudenská J, "Occupational burnout syndrome and post-traumatic stress among healthcare professionals during the novel coronavirus disease 2019(COVID-19)pandemic", Best Pract Res Clin Anaesthesiol, 34, pp.553~560 (2020)
  5. Carmassi C, "PTSD symptoms in healthcare workers facing the three coronavirus outbreaks : what can we expect after the COVID-19 pandemic", Psychiatry Res, 292, pp.113312~ (2020)
  6. Elaheh Haghgoshayie, "Healthcare workers are at risk of acute or post-traumatic stress and psychological distress during emerging virus outbreaks", Evidence Based Nursing, 24(4), pp.136~136 (2021), BMJ[DOI]
  7. Maunder R, "The experience of the 2003 SARS outbreak as a traumatic stress among frontline healthcare workers in Toronto : lessons learned", Philos Trans R Soc Lond B Biol Sci, 359, pp.1117~1125 (2004)
  8. Akira Kishimoto, "Post-traumatic Stress Disorder Symptoms in a Female Patient Following Repeated Teasing: Treatment with Gabapentin and Lamotrigine and the Possible Role of Sensitization", Clinical Psychopharmacology and Neuroscience, 12(3), pp.240~242 (2014), 대한정신약물학회
  9. 배성만, "Comparison of Memory Function and MMPI-2 Profile between Post-traumatic Stress Disorder and Adjustment Disorder after a Traffic Accident", Clinical Psychopharmacology and Neuroscience, 12(1), pp.41~47 (2014), 대한정신약물학회
  10. Shi L, "Prevalence and correlates of symptoms of post-traumatic stress disorder among Chinese healthcare workers exposed to physical violence : a cross-sectional study", BMJ Open, 7, pp.e016810~ (2017)
  11. Claudia Carmassi, "Defining effective strategies to prevent post-traumatic stress in healthcare emergency workers facing the COVID-19 pandemic in Italy", CNS Spectrums, 26(6), pp.553~554 (2021), Cambridge University Press (CUP)[DOI]
  12. Sutherland ME, "Identifying treatment-resistant PTSD", Nat Hum Behav, 3, pp.549~ (2019)
  13. "Riv Psichiatr", 2020, 255~261
  14. Warner MD, "Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares", Pharmacopsychiatry, 34, pp.128~131 (2001)
  15. Detweiler MB, "Treatment of post-traumatic stress disorder nightmares at a veterans affairs medical center", J Clin Med, 5, pp.117~ (2016)
  16. Goracci A, "Practical guidance for prescribing trazodone extended-release in major depression", Expert Opin Pharmacother, 17, pp.433~441 (2016)
  17. Cuomo A, "Clinical guidance for the use of trazodone in major depressive disorder and concomitant conditions : pharmacology and clinical practice", Riv Psichiatr, 54, pp.137~149 (2019)
  18. Riley DS, "CARE guidelines for case reports : explanation and elaboration document", J Clin Epidemiol, 89, pp.218~235 (2017)
  19. Pettersson A, "The Mini-International Neuropsychiatric Interview is useful and well accepted as part of the clinical assessment for depression and anxiety in primary care : a mixed-methods study", BMC Fam Pract, 19, pp.19~ (2018)
  20. López CM, "Residual insomnia and nightmares postintervention symptom reduction among veterans receiving treatment for Comorbid PTSD and depressive symptoms", Behav Ther, 50, pp.910~923 (2019)
  21. De Berardis D, "Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug naïve patients with post-traumatic stress disorder : an exploratory study in the everyday ‘real world’ clinical practice", Int J Psychiatry Clin Pract, 24, pp.83~87 (2020)
  22. De Berardis D, "Targeting the noradrenergic system in posttraumatic stress disorder : a systematic review and metaanalysis of prazosin trials", Curr Drug Targets, 16, pp.1094~1106 (2015)
  23. Christopher Reist, "Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis", CNS Spectrums, 26(4), pp.338~344 (2021), Cambridge University Press (CUP)[DOI]
  24. Maguire PA, "Reappraising prazosin for night-time symptoms in post-traumatic stress disorder", Aust N Z J Psychiatry, 54, pp.848~849 (2020)
  25. Sema Ketenci, "The Neurochemical Effects of Prazosin Treatment on Fear Circuitry in a Rat Traumatic Stress Model", Clinical Psychopharmacology and Neuroscience, 18(2), pp.219~230 (2020), 대한정신약물학회[DOI]
  26. Vgontzas AN, "Effects of trazodone versus cognitive behavioral therapy in the insomnia with short sleep duration phenotype : a preliminary study", J Clin Sleep Med, 16, pp.2009~2019 (2020)
  27. Montalbano A, "Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism", PLoS One, 14, pp.e0222855~ (2019)
  28. "Pol Merkur Lekarski", 2011, 65~70
  29. "Presse Med", 2019, 1051~1058
  30. Guina J, "Benzodiazepines for PTSD : a systematic review and meta-analysis", J Psychiatr Pract, 21, pp.281~303 (2015)
  31. Gilbert M, "An emulation of randomized trials of administrating benzodiazepines in PTSD patients for outcomes of suicide-related events", J Clin Med, 9, pp.3492~ (2020)
  32. Guina J, "PTSD symptom severities, interpersonal traumas, and benzodiazepines are associated with substance-related problems in trauma patients", J Clin Med, 5, pp.70~ (2016)
  33. MacNamara A, "Emotion regulatory brain function and SSRI treatment in PTSD : neural correlates and predictors of change", Neuropsychopharmacology, 41, pp.611~618 (2016)
  34. Fagiolini A, "A randomized, double-blind study comparing the efficacy and safety of trazodone once-a-day and venlafaxine extended-release for the treatment of patients with major depressive disorder", Int Clin Psychopharmacol, 35, pp.137~146 (2020)
  35. Hoffelt C, "A review of significant pharmacokinetic drug interactions with antidepressants and their management", Ment Health Clin, 6, pp.35~41 (2016)
  36. Adiukwu F, "COVID-19 mental health care toolkit : an international collaborative effort by Early Career Psychiatrists section", Gen Psychiatr, 33, pp.e100270~ (2020)
  37. Ransing R, "Can COVID-19 related mental health issues be measured?", Brain Behav Immun, 88, pp.32~34 (2020)
  38. Kemal Tolga Saracoglu, "The Psychological Impact of COVID-19 Disease is more Severe on Intensive Care Unit Healthcare Providers: A Cross-sectional Study", Clinical Psychopharmacology and Neuroscience, 18(4), pp.607~615 (2020), 대한정신약물학회[DOI]
  39. Ju-Wan Kim, "Telephone based Interventions for Psychological Problems in Hospital Isolated Patients with COVID-19", Clinical Psychopharmacology and Neuroscience, 18(4), pp.616~620 (2020), 대한정신약물학회[DOI]
  40. Pereira-Sanchez V, "COVID-19 effect on mental health : patients and workforce", Lancet Psychiatry, 7, pp.e29~ (2020)
  41. Ransing R, "Mental health interventions during the COVID-19 pandemic : a conceptual framework by early career psychiatrists", Asian J Psychiatr, 51, pp.102085~ (2020)
  42. Ransing R, "Infectious disease outbreak related stigma and discrimination during the COVID-19 pandemic : drivers, facilitators, manifestations, and outcomes across the world", Brain Behav Immun, 89, pp.555~558 (2020)

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