Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two Cases
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초록
Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D2/D3 receptors with preferential binding to the D3 receptor, antagonism of 5HT2B receptors, and partial agonism of 5HT1A. Currently, cariprazine has shown clinical efficacy in patients with schizophrenia and with bipolar disorder, as well as adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. In the present case series, we report on two patients with treatment-resistant schizophrenia and partial response to clozapine who benefit from combination with cariprazine. The effects of cariprazine combination were remarkable also concerning the adverse metabolic effects of clozapine.
Abstract
Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D2/D3 receptors with preferential binding to the D3 receptor, antagonism of 5HT2B receptors, and partial agonism of 5HT1A. Currently, cariprazine has shown clinical efficacy in patients with schizophrenia and with bipolar disorder, as well as adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. In the present case series, we report on two patients with treatment-resistant schizophrenia and partial response to clozapine who benefit from combination with cariprazine. The effects of cariprazine combination were remarkable also concerning the adverse metabolic effects of clozapine.
참고문헌 (35)
- Galderisi S, "Interplay among psychopathologic variables, personal resources, context-related factors, and real-life functioning in individuals with schizophrenia : a network analysis", JAMA Psychiatry, 75, pp.396~404 (2018)
- Iasevoli F, "Treatment resistant schizophrenia is associated with the worst community functioning among severely-ill highly-disabling psychiatric conditions and is the most relevant predictor of poorer achievements in functional milestones", Prog Neuropsychopharmacol Biol Psychiatry, 65, pp.34~48 (2016)
- De Berardis D, "Safety and efficacy of combined clozapine-azathioprine treatment in a case of resistant schizophrenia associated with Behçet's disease : a 2-year follow-up", Gen Hosp Psychiatry, 35, pp.213~ (2013)
- De Berardis D, "Treatment resistance in psychiatry: risk factors, biology, and management", pp.349~367 (2019), Springer
- De Berardis D, "Safety of antipsychotics for the treatment of schizophrenia : a focus on the adverse effects of clozapine", Ther Adv Drug Saf, 9, pp.237~256 (2018)
- Stahl SM, "Mechanism of action of cariprazine", CNS Spectr, 21, pp.123~127 (2016)
- Misiak B, "Cariprazine-a novel antipsychotic drug and its place in the treatment of schizophrenia", Psychiatr Pol, 52, pp.971~981 (2018)
- Chhatlani A, "Use of cariprazine in psychiatric disorders : a systematic review", Ann Clin Psychiatry, 30, pp.326~334 (2018)
- McCormack PL, "Cariprazine : first global approval", Drugs, 75, pp.2035~2043 (2015)
- "Neuropsychopharmacol Hung", 2019, 103~118
- cariprazine : an in vivo positron emission tomography study in nonhuman primates, "Synapse", 2013, 258~264
- Corponi F, "Novel antipsychotics specificity profile : a clinically oriented review of lurasidone, brexpiprazole, cariprazine and lumateperone", Eur Neuropsychopharmacol, 29, pp.971~985 (2019)
- Citrome L, "Cariprazine : chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability", Expert Opin Drug Metab Toxicol, 9, pp.193~206 (2013)
- Ragguett RM, "Cariprazine for the treatment of bipolar depression : a review", Expert Rev Neurother, 19, pp.317~323 (2019)
- Domenico De Berardis, "Rapid improvement of obsessive-compulsive disorder associated with schizophrenia with cariprazine add-on in a subject under paliperidone long-acting injection", International Clinical Psychopharmacology, 35(2), pp.113~118 (2019), Ovid Technologies (Wolters Kluwer Health)[DOI]
- De Berardis D, "The novel antipsychotic cariprazine(RGH-188) : state-of-the-art in the treatment of psychiatric disorders", Curr Pharm Des, 22, pp.5144~5162 (2016)
- Orsolini L, "Cariprazine (RGH-188): a new pharmacological target option for the treatment of schizophrenia, bipolar disorders and depression?", Minerva Psichiatr, 58, pp.17~25 (2017)
- Huang M, "The role of dopamine D3 receptor partial agonism in cariprazineinduced neurotransmitter efflux in rat hippocampus and nucleus accumbens", J Pharmacol Exp Ther, 371, pp.517~525 (2019)
- Gründer G, "Cariprazine, an orally active D2", D3 receptor antagonist, for the potential treatment of schizophrenia, bipolar mania and depression, 2010, pp.11, 823~832
- Calabrese F, "The role of dopamine D3 receptors in the mechanism of action of cariprazine", CNS Spectr, pp.1~9 (2019)
- Zhao MJ, "Efficacy and acceptability of cariprazine in acute exacerbation of schizophrenia : meta-analysis of randomized placebo-controlled trials", J Clin Psychopharmacol, 38, pp.55~59 (2018)
- Fleischhacker W, "The efficacy of cariprazine in negative symptoms of schizophrenia : Post hoc analyses of PANSS individual items and PANSS-derived factors", Eur Psychiatry, 58, pp.1~9 (2019)
- Frank A, "Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor", Sci Rep, 8, pp.12509~ (2018)
- Werner FM, "Safety of antipsychotic drugs : focus on therapeutic and adverse effects", Expert Opin Drug Saf, 13, pp.1031~1042 (2014)
- Moritz AE, "Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds", Cell Signal, 41, pp.75~81 (2018)
- Stahl SM, "Drugs for psychosis and mood : unique actions at D3, D2, and D1 dopamine receptor subtypes", CNS Spectr, 22, pp.375~384 (2017)
- Werner FM, "Neural networks in neurological and psychiatric diseases", Curr Pharm Des, 25, pp.374~375 (2019)
- Herman A, "Involvement of 5-HT1A and 5-HT2A receptors but not 2-adrenoceptors in the acute electrophysiological effects of cariprazine in the rat brain in vivo", Mol Pharmacol, 94, pp.1363~1370 (2018)
- Nakamura T, "Clinical pharmacology study of cariprazine(MP-214)in patients with schizophrenia(12-week treatment)", Drug Des Devel Ther, 10, pp.327~338 (2016)
- Thorn CF, "PharmGKB summary : clozapine pathway, pharmacokinetics", Pharmacogenet Genomics, 28, pp.214~222 (2018)
- Schoretsanitis G, "A comprehensive review of the clinical utility of and a combined analysis of the clozapine", norclozapine ratio in therapeutic drug monitoring for adult patients, 2019, pp.12, 603~621
- Tóth K, "Potential role of patients' CYP3A-status in clozapine pharmacokinetics", Int J Neuropsychopharmacol, 20, pp.529~537 (2017)
- Barnes SA, "The effects of cariprazine and aripiprazole on PCP-induced deficits on attention assessed in the 5-choice serial reaction time task", Psychopharmacology(Berl), 235, pp.1403~1414 (2018)
- Halaris A, "Metabolic syndrome reversal with cariprazine", J Clin Psychopharmacol, 39, pp.413~416 (2019)
- Nasrallah HA, "The safety and tolerability of cariprazine in long-term treatment of schizophrenia : a post hoc pooled analysis", BMC Psychiatry, 17, pp.305~ (2017)
