Transcranial Direct Current Stimulation in Schizophrenia
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초록
Transcranial direct current stimulation (tDCS) is an upcoming treatment modality for patients with schizophrenia. A series of recent observations have demonstrated improvement in clinical status of schizophrenia patients with tDCS. This review summarizes the research work that has examined the effects of tDCS in schizophrenia patients with respect to symptom amelioration, cognitive enhancement and neuroplasticity evaluation. tDCS is emerging as a safe, rapid and effective treatment for various aspects of schizophrenia symptoms ranging from auditory hallucinations−for which the effect is most marked, to negative symptoms and cognitive symptoms as well. An interesting line of investigation involves using tDCS for altering and examining neuroplasticity in patients and healthy subjects and is likely to lead to new insights into the neurological aberrations and pathophysiology of schizophrenia. The mechanistic aspects of the technique are discussed in brief. Future work should focus on establishing the clinical efficacy of this novel technique and on evaluating this modality as an adjunct to cognitive enhancement protocols. Understanding the mechanism of action of tDCS as well as the determinants and neurobiological correlates of clinical response to tDCS remains an important goal, which will help us expand the clinical applications of tDCS for the treatment of patients with schizophrenia.
Abstract
Transcranial direct current stimulation (tDCS) is an upcoming treatment modality for patients with schizophrenia. A series of recent observations have demonstrated improvement in clinical status of schizophrenia patients with tDCS. This review summarizes the research work that has examined the effects of tDCS in schizophrenia patients with respect to symptom amelioration, cognitive enhancement and neuroplasticity evaluation. tDCS is emerging as a safe, rapid and effective treatment for various aspects of schizophrenia symptoms ranging from auditory hallucinations−for which the effect is most marked, to negative symptoms and cognitive symptoms as well. An interesting line of investigation involves using tDCS for altering and examining neuroplasticity in patients and healthy subjects and is likely to lead to new insights into the neurological aberrations and pathophysiology of schizophrenia. The mechanistic aspects of the technique are discussed in brief. Future work should focus on establishing the clinical efficacy of this novel technique and on evaluating this modality as an adjunct to cognitive enhancement protocols. Understanding the mechanism of action of tDCS as well as the determinants and neurobiological correlates of clinical response to tDCS remains an important goal, which will help us expand the clinical applications of tDCS for the treatment of patients with schizophrenia.
참고문헌 (52)
- Tandon R, "Schizophrenia, “just the facts” 5. Treatment and prevention. Past, present, and future", Schizophr Res, 122, pp.1~23 (2010)
- Kapur S, "Half a century of antipsychotics and still a central role for dopamine D2 receptors", Prog Neuropsychopharmacol Biol Psychiatry, 27, pp.1081~1090 (2003)
- Abbott A, "Schizophrenia: The drug deadlock", Nature, 468, pp.158~159 (2010)
- Torrey EF, "Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas", Clin Schizophr Relat Psychoses, 5, pp.208~216 (2012)
- George MS, "Controversy: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation shows efficacy in treating psychiatric diseases (depression, mania, schizophrenia, obsessive-complusive disorder, panic, posttraumatic stress disorder)", Brain Stimul, 2, pp.14~21 (2009)
- Steinberg H, "A pioneer work on electric brain stimulation in psychotic patients. Rudolph Gottfried Arndt and his 1870s studies", Brain Stimul, 6, pp.477~481 (2013)
- Rajji TK, "Neuroplasticity-based brain stimulation interventions in the study and treatment of schizophrenia: a review", Can J Psychiatry, 58, pp.93~98 (2013)
- Guleyupoglu B, "Classification of methods in transcranial electrical stimulation (tES) and evolving strategy from historical approaches to contemporary innovations", J Neurosci Methods, 219, pp.297~311 (2013)
- Brunoni AR, "Clinical research with transcranial direct current stimulation (tDCS): challenges and future directions", Brain Stimul, 5, pp.175~195 (2012)
- Nitsche MA, "Transcranial direct current stimulation: State of the art 2008", Brain Stimul, 1, pp.206~223 (2008)
- Priori A, "Brain polarization in humans: a reappraisal of an old tool for prolonged non-invasive modulation of brain excitability", Clin Neurophysiol, 114, pp.589~595 (2003)
- Fregni F, "Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS", Nat Clin Pract Neurol, 3, pp.383~393 (2007)
- Nitsche MA, "Treatment of depression with transcranial direct current stimulation (tDCS): a review", Exp Neurol, 219, pp.14~19 (2009)
- Hauser TU, "Enhancing performance in numerical magnitude processing and mental arithmetic using transcranial Direct Current Stimulation (tDCS)", Front Hum Neurosci, 7, pp.244~ (2013)
- Fitz NS, "The challenge of crafting policy for do-it-yourself brain stimulation", J Med Ethics (2013)
- Kadosh RC, "The neuroethics of non-invasive brain stimulation", Curr Biol, 22, pp.R108~R111 (2012)
- Homan P, "Muting the voice: a case of arterial spin labeling-monitored transcranial direct current stimulation treatment of auditory verbal hallucinations", Am J Psychiatry, 168, pp.853~854 (2011)
- Mattai A, "Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia", Brain Stimul, 4, pp.275~280 (2011)
- Brunelin J, "Efficacy and safety of bifocal tDCS as an interventional treatment for refractory schizophrenia", Brain Stimul, 5, pp.431~432 (2012)
- Brunelin J, "Examining transcranial directcurrent stimulation (tDCS) as a treatment for hallucinations in schizophrenia", Am J Psychiatry, 169, pp.719~724 (2012)
- Andrade C, "Once- to twice-daily, 3-year domiciliary maintenance transcranial direct current stimulation for severe, disabling, clozapine-refractory continuous auditory hallucinations in schizophrenia", J ECT, 29, pp.239~242 (2013)
- Rakesh G, "Monotherapy with tDCS for Schizophrenia: a case report", Brain Stimul, 6, pp.708~709 (2013)
- Shivakumar V, "Rapid improvement of auditory verbal hallucinations in schizophrenia after add-on treatment with transcranial direct-current stimulation", J ECT, 29, pp.e43~e44 (2013)
- Shiozawa P, "Transcranial direct current stimulation (tDCS) for catatonic schizophrenia: a case study", Schizophr Res, 146, pp.374~375 (2013)
- Shiozawa P, "Transcranial direct current stimulation (tDCS) for the treatment of persistent visual and auditory hallucinations in schizophrenia: A case study", Brain Stimul, 6, pp.831~833 (2013)
- Palm U, "Prefrontal transcranial direct current stimulation (tDCS) changes negative symptoms and functional connectivity MRI (fcMRI) in a single case of treatmentresistant schizophrenia", Schizophr Res, 150, pp.583~585 (2013)
- Shiozawa P, "Safety of repeated transcranial direct current stimulation in impaired skin: a case report", J ECT, 29, pp.147~148 (2013)
- Vercammen A, "Transcranial direct current stimulation influences probabilistic association learning in schizophrenia", Schizophr Res, 131, pp.198~205 (2011)
- Ribolsi M, "Perceptual pseudoneglect in schizophrenia: candidate endophenotype and the role of the right parietal cortex", Schizophr Bull, 39, pp.601~607 (2013)
- Göder R, "Effects of transcranial direct current stimulation during sleep on memory performance in patients with schizophrenia", Schizophr Res, 144, pp.153~154 (2013)
- Sommer IE, "Transcranial stimulation for psychosis: the relationship between effect size and published findings", Am J Psychiatry, 169, pp.1211~ (2012)
- Slotema CW, "Meta-analysis of repetitive transcranial magnetic stimulation in the treatment of auditory verbal hallucinations: updateand effects after one month", Schizophr Res, 142, pp.40~45 (2012)
- Hasan A, "Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation", Behav Brain Res, 224, pp.15~22 (2011)
- Hasan A, "Impaired long-term depression in schizophrenia: a cathodal tDCS pilot study", Brain Stimul, 5, pp.475~483 (2012)
- Hasan A, "Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation", Eur Arch Psychiatry Clin Neurosci, 262, pp.415~423 (2012)
- Hasan A, "Impaired motor cortex responses in non-psychotic first-degree relatives of schizophrenia patients: a cathodal tDCS pilot study", Brain Stimul, 6, pp.821~829 (2013)
- Nawani H, "Neural basis of tDCS effects on auditory verbal hallucinations in schizophrenia: A case report evidence for cortical neuroplasticity modulation", J ECT (2013)
- Hasan A, "Impairments of motor-cortex responses to unilateral and bilateral direct current stimulation in schizophrenia", Front Psychiatry, 4, pp.121~ (2013)
- Hasan A, "Modulating neural plasticity with non-invasive brain stimulation in schizophrenia", Eur Arch Psychiatry Clin Neurosci, 263, pp.621~631 (2013)
- Nitsche MA, "Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation", J Physiol, 527(Pt 3), pp.633~639 (2000)
- Liebetanz D, "Pharmacological approach to the mechanisms of transcranial DC-stimulation- induced after-effects of human motor cortex excitability", Brain, 125, pp.2238~2247 (2002)
- Antal A, "Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans", Brain Stimul, 3, pp.230~237 (2010)
- Fritsch B, "Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning", Neuron, 66, pp.198~204 (2010)
- Kalmady SV, "Relationship between brain-derived neurotrophic factor and schneiderian first rank symptoms in antipsychotic-naïve schizophrenia", Front Psychiatry, 4, pp.64~ (2013)
- Chib VS, "Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex", Transl Psychiatry, 3, pp.e268~ (2013)
- Krause B, "The effect of transcranial direct current stimulation: a role for cortical excitation", inhibition balance?, 2013, pp.7, 602~
- Behrendt RP, "Hallucinations in schizophrenia, sensory impairment, and brain disease: a unifying model", Behav Brain Sci, 27, pp.771~787 (2004)
- Demirtas-Tatlidede A, "Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?", Neuropharmacology, 64, pp.566~578 (2013)
- Ditye T, "Modulating behavioral inhibition by tDCS combined with cognitive training", Exp Brain Res, 219, pp.363~368 (2012)
- Palm U, "Transcranial random noise stimulation for the treatment of negative symptoms in schizophrenia", Schizophr Res, 146, pp.372~373 (2013)
- Villamar MF, "Technique and considerations in the use of 4x1 ring high-definition transcranial direct current stimulation (HD-tDCS)", J Vis Exp, (77), pp.e50309~ (2013)
- Park JH, "A novel array-type transcranial direct current stimulation (tDCS) system for accurate focusing on targeted brain areas", Magnetics, IEEE Transactions, 47, pp.882~885 (2011)