본문 바로가기
KERD
논문KCI 등재

Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Objective: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. Methods: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. Results: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. Conclusion: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.

Abstract

Objective: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. Methods: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. Results: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. Conclusion: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.

참고문헌 (30)

  1. Headache Classification Committee of the InternationalHeadache Society (IHS), "The International Classification of Headache Disorders, 3rd edition (beta version)", Cephalalgia, 33, pp.629~808 (2013)
  2. Mulder EJ, "Genetic and environmental influences on migraine: a twin study across six countries", Twin Res, 6, pp.422~431 (2003)
  3. Hamel E, "Serotonin and migraine: biology and clinical implications", Cephalalgia, 27, pp.1293~1300 (2007)
  4. Shih-Hsien Lin, "Serotonin and Mental Disorders: A Concise Review on Molecular Neuroimaging Evidence", Clinical Psychopharmacology and Neuroscience, 12(3), pp.196~202 (2014), 대한정신약물학회
  5. Ferrari MD, "Serotonin metabolism in migraine", Neurology, 39, pp.1239~1242 (1989)
  6. Hannon J, "Molecular biology of 5-HT receptors", Behav Brain Res, 195, pp.198~213 (2008)
  7. Sokolov A, "The role of serotonin receptors in migraine headaches", Neurochem J, 5, pp.92~99 (2011)
  8. Albert PR, "Transcriptional regulation of the 5-HT1A receptor: implications for mental illness", Philos Trans R Soc Lond B Biol Sci, 367, pp.2402~2415 (2012)
  9. Ates O, "Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population", J Neurol Sci, 326, pp.64~67 (2013)
  10. Lemonde S, "Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide", J Neurosci, 23, pp.8788~8799 (2003)
  11. Marziniak M, "A functional serotonin transporter gene polymorphism is associated with migraine with aura", Neurology, 64, pp.157~159 (2005)
  12. Fehr C, "The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy", Psychiatry Res, 97, pp.1~10 (2000)
  13. Huang YY, "Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism", Neuropsychopharmacology, 28, pp.163~169 (2003)
  14. Mundo E, "Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder?", Am J Psychiatry, 157, pp.1160~1161 (2000)
  15. Racchi M, "Familial migraine with aura: association study with 5-HT1B", 1D, 5-HT2C, and hSERT polymorphisms, 2004, pp.44, 311~317
  16. Cao J, "Association of the HTR2A gene with alcohol and heroin abuse", Hum Genet, 133, pp.357~365 (2014)
  17. Erdal ME, "Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine", J Neurol Sci, 188, pp.99~101 (2001)
  18. Filippini N, "Influence of serotonin receptor 2A His452Tyr polymorphism on brain temporal structures:a volumetric MR study", Eur J Hum Genet, 14, pp.443~449 (2006)
  19. Schott BH, "Genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans", PLoS One, 6, pp.e15984~ (2011)
  20. Kusumi M, "Serotonin 2C receptor gene Cys23Ser polymorphism:a candidate genetic risk factor of migraine with aura in Japanese population", Acta Neurol Scand, 109, pp.407~409 (2004)
  21. Okada M, "Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution", Mol Psychiatry, 9, pp.55~64 (2004)
  22. Oterino A, "Genetic association study and metaanalysis of the HTR2C Cys23Ser polymorphism and migraine", J Headache Pain, 8, pp.231~235 (2007)
  23. Bah J, "Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight", Metabolism, 59, pp.1156~1163 (2010)
  24. Reynolds GP, "Pharmacogenetics of treatment in first-episode schizophrenia: D3and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response", Eur Neuropsychopharmacol, 15, pp.143~151 (2005)
  25. Yuan X, "Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes", Diabetologia, 43, pp.373~376 (2000)
  26. Corominas R, "Association study of the serotoninergic system in migraine in the Spanish population", Am J Med Genet B Neuropsychiatr Genet, 153B, pp.177~184 (2010)
  27. Guglielmo R, "A possible new option for migraine management: agomelatine", Clin Neuropharmacol, 36, pp.65~67 (2013)
  28. Hill MJ, "5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activity", Brain Res, 1149, pp.14~17 (2007)
  29. Yang XS, "No association of C-1019G promoter polymorphism of 5-HT1A receptor gene with migraine", Eur J Neurol, 13, pp.533~535 (2006)
  30. Naito Y, "Association of the A-1438G polymorphism in serotonin 2A receptor in migraine with aura among Japanese patients", Biol Pharm Bull, 33, pp.1751~1753 (2010)

관련 논문AI추천

Migraine Susceptibility Genes in Han Chinese of Fujian ProvinceGen-bin Huang, Jing Yang, Long-teng Yao, Luo-yuan Cao, Qi-fang Lin, Xian-guo Fu, Yong-tong Xin, Zi-chun Chen대한신경과학회 · Journal of Clinical Neurology2017 · 제13권 제1호Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura김영인, 김중석, 박정욱, 신혜은, 이광수대한신경과학회 · Journal of Clinical Neurology2007 · 제3권 제1호Association between the G252A Tumor Necrosis Factor-β Gene Polymorphism and Medication-Overuse HeadacheHideyo Kasai, Hirotaka Katoh, Masakazu Ishii, Mitsuru Kawamura, Shunichi Shimizu, Tomomi Onaya, Yuji Kiuchi대한신경과학회 · Journal of Clinical Neurology2012 · 제8권 제4호Polymorphism of the Glutamate Transporter Protein EAAT2 and Migraine Transformation into Chronic Daily Headache박정욱, 신혜은, 이광수, 한수정대한신경과학회 · Journal of Clinical Neurology2011 · 제7권 제3호만성 긴장형두통 및 편두통 환자들에서 세로토닌 수송체 다형성과 위해 회피 인성차원김영인, 김중석, 박정욱, 이광수대한신경과학회 · 대한신경과학회지2005 · 제23권 제2호Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of TaiwanChia-Lin Tsai, Chih-Sung Liang, Fu-Chi Yang, Guan-Yu Lin, Kuo-Sheng Hung, Ming-Chen Tsai, Po-Kuan Yeh, Yi Liu, Yu-Chin An, Yu-Kai Lin대한신경과학회 · Journal of Clinical Neurology2024 · 제20권 제4호

이 간행물의 다른 논문 (14건)