Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice
1
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Objective: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. Methods: MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Beginning on the sixth day of MK-801 treatment, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minutes prior to MK-801 for the final 4 days. Spatial memory performance was measured using a Morris water maze (MWM) test for 9 days (four trials/day). Immunohistochemistry with bromodeoxyuridine (BrdU) was used to identify newborn cells labeled in tissue sections from the dentate gyrus of the hippocampus. Results: MK-801 administration over 9 days significantly impaired memory performance in the MWM test compared to untreated controls (p<0.05) and these deficits were blocked by treatment with olanzapine (p<0.05) but not haloperidol. The administration of MK-801 also resulted in a decrease in the number of BrdU-labeled cells in the dentate gyrus (28.6%; p<0.01), which was prevented by treatment with olanzapine (p<0.05) but not haloperidol. Conclusion: These results suggest that olanzapine has a protective effect against cognitive impairments induced by MK-801 in mice via the stimulating effects of neurogenesis.
Abstract
Objective: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. Methods: MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Beginning on the sixth day of MK-801 treatment, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minutes prior to MK-801 for the final 4 days. Spatial memory performance was measured using a Morris water maze (MWM) test for 9 days (four trials/day). Immunohistochemistry with bromodeoxyuridine (BrdU) was used to identify newborn cells labeled in tissue sections from the dentate gyrus of the hippocampus. Results: MK-801 administration over 9 days significantly impaired memory performance in the MWM test compared to untreated controls (p<0.05) and these deficits were blocked by treatment with olanzapine (p<0.05) but not haloperidol. The administration of MK-801 also resulted in a decrease in the number of BrdU-labeled cells in the dentate gyrus (28.6%; p<0.01), which was prevented by treatment with olanzapine (p<0.05) but not haloperidol. Conclusion: These results suggest that olanzapine has a protective effect against cognitive impairments induced by MK-801 in mice via the stimulating effects of neurogenesis.
참고문헌 (50)
- Stahl SM, "Stahl's essential psychopharmacology", pp.247~253 (2008), Cambridge University Press
- Citrome L, "Unmet needs in the treatment of schizophrenia:new targets to help different symptom domains", J Clin Psychiatry, 75(Suppl 1), pp.21~26 (2014)
- Yatham LN, "Atypical antipsychotics in bipolar depression: potential mechanisms of action", J Clin Psychiatry, 66(Suppl 5), pp.40~48 (2005)
- Keefe RS, "Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial", Arch Gen Psychiatry, 64, pp.633~647 (2007)
- Meltzer HY, "Psychopharmacology", pp.1277~1286 (1995), Raven Press
- Lieberman JA, "Antipsychotic drug effects on brain morphology in first-episode psychosis", Arch Gen Psychiatry, 62, pp.361~370 (2005)
- Thompson PM, "Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia", Proc Natl Acad Sci U S A, 98, pp.11650~11655 (2001)
- Bai O, "Protective effects of atypical antipsychotic drugs on PC12cells after serum withdrawal", J Neurosci Res, 69, pp.278~283 (2002)
- Luo C, "Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress", Brain Res, 1063, pp.32~39 (2005)
- Wang HD, "Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat", Neuropsychopharmacology, 29, pp.1230~1238 (2004)
- Wei Z, "Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide", J Neurosci Res, 73, pp.364~368 (2003)
- Wei Z, "Atypical antipsychotics attenuate neurotoxicity of betaamyloid(25-35) by modulating Bax and Bcl-X(l", s) expression and localization, 2003, pp.74, 942~947
- Yulug B, "Olanzapine attenuates brain damage after focal cerebral ischemia in vivo", Brain Res Bull, 71, pp.296~300 (2006)
- Behl C, "Haloperidolinduced cell death--mechanism and protection with vitamin E in vitro", Neuroreport, 7, pp.360~364 (1995)
- Noh JS, "Haloperidol-induced neuronal apoptosis: role of p38and c-Jun-NH(2)-terminal protein kinase", J Neurochem, 75, pp.2327~2334 (2000)
- Ogren SO, "Phencyclidine- and dizocilpineinduced hyperlocomotion are differentially mediated", Neuropsychopharmacology, 11, pp.167~177 (1994)
- Corbett R, "Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors", Psychopharmacology (Berl), 120, pp.67~74 (1995)
- Moghaddam B, "Glutamatergic animal models of schizophrenia", Ann N Y Acad Sci, 1003, pp.131~137 (2003)
- Javitt DC, "Recent advances in the phencyclidine model of schizophrenia", Am J Psychiatry, 148, pp.1301~1308 (1991)
- Noda Y, "Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia", Br J Pharmacol, 116, pp.2531~2537 (1995)
- Noda Y, "Repeated phencyclidine treatment induces negative symptomlike behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic functions", Neuropsychopharmacology, 23, pp.375~387 (2000)
- Ahlander M, "A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat", Neuropsychopharmacology, 21, pp.414~426 (1999)
- Eyjolfsson EM, "Repeated injection of MK801: an animal model of schizophrenia?", Neurochem Int, 48, pp.541~546 (2006)
- Zhu XJ, "Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulatingcyclic AMP response element binding protein phosphorylation", Neuroscience, 141, pp.827~836 (2006)
- Fumagalli F, "Effect of antipsychotic drugs on brainderived neurotrophic factor expression under reduced N-methyl-D-aspartate receptor activity", J Neurosci Res, 72, pp.622~628 (2003)
- Hou Y, "Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice", Prog Neuropsychopharmacol Biol Psychiatry, 30, pp.1486~1495 (2006)
- Kant GJ, "Effects of MK-801 on learning and memory as assessed using a novel water maze", Pharmacol Biochem Behav, 39, pp.479~485 (1991)
- Zuo DY, "Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior", Life Sci, 78, pp.2172~2178 (2006)
- Ahn KJ, "DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects", Neurobiol Dis, 22, pp.463~472 (2006)
- Park SW, "Antidepressant-like effects of the traditional Chinese medicine kami-shoyo-san in rats", Psychiatry Clin Neurosci, 61, pp.401~406 (2007)
- Parent JM, "Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus", J Neurosci, 17, pp.3727~3738 (1997)
- Terry AV Jr, "Differential effects of chronic haloperidol and olanzapine exposure on brain cholinergic markers and spatial learning in rats", Psychopharmacology (Berl), 164, pp.360~368 (2002)
- Terry AV Jr, "Differential effects of haloperidol, risperidone, and clozapine exposure on cholinergic markers and spatial learning performance in rats", Neuropsychopharmacology, 28, pp.300~309 (2003)
- Terry AV Jr, "Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in rats", J Pharmacol Exp Ther, 318, pp.709~724 (2006)
- Mandillo S, "Repeated administration of phencyclidine, amphetamine and MK-801selectively impairs spatial learning in mice: a possible model of psychotomimetic drug-induced cognitive deficits", Behav Pharmacol, 14, pp.533~544 (2003)
- Zemanova A, "Visuospatial working memory is impaired in an animal model of schizophrenia induced by acute MK-801: an effect of pretraining", Pharmacol Biochem Behav, 106, pp.117~123 (2013)
- Willis CL, "Antioxidants attenuate MK-801-induced cortical neurotoxicity in the rat", Neurotoxicology, 28, pp.161~167 (2007)
- Maeda K, "Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine", J Pharmacol Sci, 103, pp.299~308 (2007)
- Storozheva ZI, "Delayed effects of NMDA receptor antagonist MK-801 on storage and reconsolidation of spatial memory in rats", Bull Exp Biol Med, 153, pp.605~608 (2012)
- Keilhoff G, "Increased neurogenesis in a rat ketamine model of schizophrenia", Biol Psychiatry, 56, pp.317~322 (2004)
- Cameron HA, "Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus", J Neurosci, 15, pp.4687~4692 (1995)
- Dong C, "Ketamine alters the neurogenesis of rat cortical neural stem progenitor cells", Crit Care Med, 40, pp.2407~2416 (2012)
- Li N, "mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists", Science, 329, pp.959~964 (2010)
- Xu H, "Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus", Hippocampus, 16, pp.551~559 (2006)
- Green W, "Treatment with olanzapine increases cell proliferation in the subventricular zone and prefrontal cortex", Brain Res, 1070, pp.242~245 (2006)
- Kodama M, "Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat", Biol Psychiatry, 56, pp.570~580 (2004)
- Halim ND, "Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus", Neuropsychopharmacology, 29, pp.1063~1069 (2004)
- Kim NR, "Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH-SY5Y cells", Prog Neuropsychopharmacol Biol Psychiatry, 32, pp.633~642 (2008)
- Lee JG, "Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.1001~1006 (2010)
- Park SW, "Effects of antipsychotic drugs on BDNF, GSK-3β, and β-catenin expression in rats subjected to immobilization stress", Neurosci Res, 71, pp.335~340 (2011)
