Efficacy of Adenine in the Treatment of Leukopenia and Neutropenia Associated with an Overdose of Antipsychotics or Discontinuation of Lithium Carbonate Administration: Three Case Studies
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Because adenine is effective for managing cases of radiation-induced and drug-induced leukopenia, it may be effective in cases of antipsychotic-induced leukopenia and neutropenia. Here, we report our experience with patients with leukopenia and neutropenia caused by an antipsychotic overdose or discontinuation of lithium carbonate, in whom adenine administration ameliorated the white blood cell and neutrophil counts. The progress of patients suggests that adenine is effective in cases of leukopenia and neutropenia associated with lithium carbonate discontinuation and an antipsychotic overdose.
Abstract
Because adenine is effective for managing cases of radiation-induced and drug-induced leukopenia, it may be effective in cases of antipsychotic-induced leukopenia and neutropenia. Here, we report our experience with patients with leukopenia and neutropenia caused by an antipsychotic overdose or discontinuation of lithium carbonate, in whom adenine administration ameliorated the white blood cell and neutrophil counts. The progress of patients suggests that adenine is effective in cases of leukopenia and neutropenia associated with lithium carbonate discontinuation and an antipsychotic overdose.
참고문헌 (9)
- Lecoq R, "Anti-agranulocytic vitamin B4", Int Z Vitaminforsch Beih, 27, pp.291~300 (1957)
- Paolino W, "Effects of adenine on blood disease due to benzene poisoning", Panminerva Med, 2, pp.5~8 (1960)
- Fukui H, "Successful treatment of neuroleptic-induced neutropenia by adenine", Jpn J Psychiatr Treat, 16, pp.1085~1088 (2001)
- Ippei Takeuchi, "Effect of Adenine on Clozapine-induced Neutropenia in Patients with Schizophrenia: A Preliminary Study", Clinical Psychopharmacology and Neuroscience, 13(2), pp.157~162 (2015), 대한정신약물학회
- Mayfield D, "The clinical laboratory and electroencephalographic effects of lithium", J Psychiatr Res, 4, pp.207~219 (1966)
- Murphy DL, "Leukocytosis during lithium treatment", Am J Psychiatry, 127, pp.1559~1561 (1971)
- Shopsin B, "Lithium and leukocytosis", Clin Pharmacol Ther, 12, pp.923~928 (1971)
- Bille PE, "Studies on the haematologic and cytogenetic effect of lithium", Acta Med Scand, 198, pp.281~286 (1975)
- Watanabe S, "Leukocytosis during lithium treatment and its correlation to serum lithium level", Folia Psychiatr Neurol Jpn, 28, pp.161~165 (1974)
