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올란자핀-발프로에이트 병용 치료 시 발생한 가역적 호중구 감소증 2예

Two Cases of Reversible Neutropenia Associated with Olanzapine-Valproate Combination Treatment

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초록

The novel antipsychotic, olanzapine, has structural and pharmacological properties similar to clozaine. Antipsychotic drugs, as well as mood stabilizers, can cause neutropenia, which can progress to life-threatening agranulocytosis if the medication is not discontinued. We report two cases of reversible neutropenia associated with a olanzapine-valproate combination treatment. This report suggests that patients treated with the combination of olanzapine and valproate should be monitored for the occurrence of leukopenia and neutropenia.

Abstract

The novel antipsychotic, olanzapine, has structural and pharmacological properties similar to clozaine. Antipsychotic drugs, as well as mood stabilizers, can cause neutropenia, which can progress to life-threatening agranulocytosis if the medication is not discontinued. We report two cases of reversible neutropenia associated with a olanzapine-valproate combination treatment. This report suggests that patients treated with the combination of olanzapine and valproate should be monitored for the occurrence of leukopenia and neutropenia.

참고문헌 (24)

  1. Alvir JM, "Clozapine-induced agranulocytosis. Incidence and risk factors in the United States", N Engl J Med, 329, pp.162~167 (1993)
  2. Casey DE, "The relationship of pharmacology to side effects", J Clin Psychiatry, 58(Supple 10), pp.55~62 (1997)
  3. Beasley CM, "Safety of olanzapine", J Clin Psychiatry, 58(Suppl 10), pp.13~17 (1997)
  4. Thinn SS, "Reversible delayed onset olanzapine-associated leucopenia and neutropenia in a clozapinenaive patient on concomitant depot antipsychotic", J Clin Psychopharmacol, 27, pp.394~395 (2007)
  5. Cordes J, "Reversible neutropenia during treatment with olanzapine: three case reports", World J Biol Psychiatry, 5, pp.230~234 (2004)
  6. Su JA, "Olanzapine-induced agranulocytosis in systemic lupus erythematosus: a case report", Gen Hosp Psychiatry, 29, pp.75~77 (2007)
  7. Stip E, "Fatal agranulocytosis: the use of olanzapine in a patient with schizophrenia and myelodysplasia", Prog Neuropsychopharmacol Biol Psychiatry, 31, pp.297~300 (2007)
  8. Sayin A, "Prolongation of clozapine-induced leucopenia with olanzapine treatment", Prog Neuropsychopharmacol Biol Psychiatry, 30, pp.958~959 (2006)
  9. Shankar BR, "Quetiapine-induced leukopenia and thrombocytopenia", Psychosomatics, 486, pp.530~531 (2007)
  10. Burckart GJ, "Neutropenia following acute chlorpromazine ingestion", Clin Toxicol, 18, pp.797~801 (1981)
  11. Tohen M, "Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk", Am J Psychiatry, 152, pp.413~418 (1995)
  12. Teter CJ, "Olanzapine-induced neutropeina in patients with history of clozapine treatment: two case reports from a state psychiatric institution", J Clin Psychiatry, 61, pp.872~873 (2000)
  13. Thangadurai P, "Reversible neutropenia with olanzapine following clozapine-induced neutropenia", Am J Psychiatry, 163, pp.1298~ (2006)
  14. Duggal HS, "Psychotropic drug-induced neutropenia", Drugs Today (Barc), 41, pp.517~526 (2005)
  15. Steinwachs A, "Two cases of olanzapine-induced reversible neutropenia", Pharmacopsychiatry, 32, pp.154~156 (1999)
  16. Rahman A, "Evaluating the incidence of leukopenia and neutropenia with valproate, quetiapine, or the combination in children and adolescents", Ann Pharmacother, 43, pp.822~830 (2009)
  17. Duggal HS, "Olanzapine-induced neutropeina: mechanism and treatment", J Clin Psychopharmacol, 24, pp.234~235 (2004)
  18. Pantelis C, "Increased risk of neutropaenia and agranulocytosis with sodium valproate used adjunctively with clozapine", Aust N Z J Psychiatry, 35, pp.544~545 (2001)
  19. Liu ZC, "Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells", J Pharmacol Exp Ther, 275, pp.1476~1483 (1995)
  20. Gardner I, "A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo", Mol Pharmacol, 53, pp.999~1008 (1998)
  21. Uetrecht JP, "Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis", Chem Res Toxicol, 8, pp.226~233 (1995)
  22. Waldhauser L, "Oxidation of propilthiouracil to reactive metabolites by activated neutrofils. Implications for agranulocytosis", Drug Metab Dispos, 19, pp.354~359 (1991)
  23. Gardner I, "A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes", Mol Pharmacol, 53, pp.991~998 (1998)
  24. Dettling M, "Genetic determinants of drug-induced agranulocytosis: potential risk of olanzapine?", Pharmacopsychiatry, 32, pp.110~112 (1999)

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