본문 바로가기
KERD
논문KCI 등재

Efficacy of Asenapine in Drug-resistant Psychotic Patients with Dopamine Supersensitivity Psychosis: Two Cases

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Dopamine supersensitivity psychosis (DSP) is an unstable clinical condition observed in individuals with schizophrenia who have been treated with an antipsychotic medication at a high dosage and/or for a long period. An up-regulation of dopamine D2 receptors (DRD2) is thought to be involved in the essential pathology of DSP. An antipsychotic agent with both tight binding to DRD2 and a long half-life is generally effective for treating DSP, but a patient who meets the criteria of treatment-resistant schizophrenia sometimes needs treatment with clozapine. We report the case details of two patients whose DSP was not controlled with several antipsychotics but was successfully controlled with asenapine. Asenapine binds to a broad range of dopamine receptors and serotonin receptors, and it is thus distinct from other atypical antipsychotics. The unique profile of asenapine may contribute to the control of severe DSP symptoms in individuals with schizophrenia.

Abstract

Dopamine supersensitivity psychosis (DSP) is an unstable clinical condition observed in individuals with schizophrenia who have been treated with an antipsychotic medication at a high dosage and/or for a long period. An up-regulation of dopamine D2 receptors (DRD2) is thought to be involved in the essential pathology of DSP. An antipsychotic agent with both tight binding to DRD2 and a long half-life is generally effective for treating DSP, but a patient who meets the criteria of treatment-resistant schizophrenia sometimes needs treatment with clozapine. We report the case details of two patients whose DSP was not controlled with several antipsychotics but was successfully controlled with asenapine. Asenapine binds to a broad range of dopamine receptors and serotonin receptors, and it is thus distinct from other atypical antipsychotics. The unique profile of asenapine may contribute to the control of severe DSP symptoms in individuals with schizophrenia.

참고문헌 (26)

  1. Iyo M, "Optimal extent of dopamine D2 receptor occupancy by antipsychotics for treatment of dopamine supersensitivity psychosis and late-onset psychosis", J Clin Psychopharmacol, 33, pp.398~404 (2013)
  2. Chouinard G, "Severe cases of neuroleptic-induced supersensitivity psychosis. Diagnostic criteria for the disorder and its treatment", Schizophr Res, 5, pp.21~33 (1991)
  3. Chouinard G, "Antipsychotic-induced dopamine supersensitivity psychosis : pharmacology, criteria, and therapy", Psychother Psychosom, 86, pp.189~219 (2017)
  4. Kimura H, "Rationale and neurobiological effects of treatment with antipsychotics in patients with chronic schizophrenia considering dopamine supersensitivity", Behav Brain Res, 403, pp.113126~ (2021)
  5. Takase M, "Dopamine supersensitivity psychosis and dopamine partial agonist : a retrospective survey of failure of switching to aripiprazole in schizophrenia", J Psychopharmacol, 29, pp.383~389 (2015)
  6. Rajkumar RP, "Supersensitivity psychosis and its response to asenapine in a patient with delusional disorder", Case Rep Psychiatry, 2014, pp.215732~ (2014)
  7. Takao N, "Treatment-resistant schizophrenia characterised by dopamine supersensitivity psychosis and efficacy of asenapine", BMJ Case Rep, 14, pp.e242495~ (2021)
  8. Chouinard G, "Risperidone and clozapine in the treatment of drug-resistant schizophrenia and neuroleptic-induced supersensitivity psychosis", Prog Neuropsychopharmacol Biol Psychiatry, 18, pp.1129~1141 (1994)
  9. Nakata Y, "Efficacy of clozapine on dopamine supersensitivity psychosis in schizophrenia", Int Clin Psychopharmacol, 32, pp.169~173 (2017)
  10. Kimura H, "Potential treatment strategy of risperidone in long-acting injectable form for schizophrenia with dopamine supersensitivity psychosis", Schizophr Res, 145, pp.130~131 (2013)
  11. Kimura H, "A prospective comparative study of risperidone long-acting injectable for treatment-resistant schizophrenia with dopamine supersensitivity psychosis", Schizophr Res, 155, pp.52~58 (2014)
  12. Kimura H, "Risperidone long-acting injectable in the treatment of treatment-resistant schizophrenia with dopamine supersensitivity psychosis : results of a 2-year prospective study, including an additional 1-year follow-up", J Psychopharmacol, 30, pp.795~802 (2016)
  13. Tachibana M, "Effectiveness of blonanserin for patients with drug treatment-resistant schizophrenia and dopamine supersensitivity : a retrospective analysis", Asian J Psychiatr, 24, pp.28~32 (2016)
  14. Niitsu T, "A randomized-controlled trial of blonanserin and olanzapine as adjunct to antipsychotics in the treatment of patients with schizophrenia and dopamine supersensitivity psychosis : the ROADS study", Asian J Psychiatr, 53, pp.102369~ (2020)
  15. Kobayashi R, "Successful rechallenge with paliperidone after clozapine treatment for a patient with dopamine supersensitivity psychosis", SAGE Open Med Case Rep, 8, pp.2050313~ (2020)
  16. Shigenori Tadokoro, "Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report", Clinical Psychopharmacology and Neuroscience, 15(1), pp.79~81 (2017), 대한정신약물학회[DOI]
  17. Kanahara N, "Combination therapy of electroconvulsive therapy and aripiprazole for dopamine supersensitivity psychosis", Schizophr Res, 202, pp.398~400 (2018)
  18. Kanahara N, "The effectiveness of very slow switching to aripiprazole in schizophrenia patients with dopamine supersensitivity psychosis : a case series from an open study", Int Clin Psychopharmacol, 35, pp.338~344 (2020)
  19. Meiji Seika Pharma Co., Ltd, "The manual of Sycrest sublingual tablets 5mg, 10mg Interview Form" (2020), Meiji Seika Pharma Co., Ltd
  20. Charron A, "5-HT2 receptors modulate the expression of antipsychotic-induced dopamine supersensitivity", Eur Neuropsychopharmacol, 25, pp.2381~2393 (2015)
  21. Hashimoto T, "Lack of dopamine supersensitivity in rats after chronic administration of blonanserin : comparison with haloperidol", Eur J Pharmacol, 830, pp.26~32 (2018)
  22. Gray JA, "The pipeline and future of drug development in schizophrenia", Mol Psychiatry, 12, pp.904~922 (2007)
  23. Baba S, "Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range", J Pharmacol Sci, 127, pp.326~331 (2015)
  24. Shahid M, "Asenapine : a novel psychopharmacologic agent with a unique human receptor signature", J Psychopharmacol, 23, pp.65~73 (2009)
  25. Shinichiro Ochi, "Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report", Clinical Psychopharmacology and Neuroscience, 17(4), pp.559~563 (2019), 대한정신약물학회[DOI]
  26. Takekita Y, "Divergence of dose-response with asenapine : a cluster analysis of randomized, double-blind, and placebo control study", CNS Spectr, 27, pp.369~377 (2022)

관련 논문AI추천

Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report갠지하시모토, Masaomi Iyo, Naho Nonomura, Nobuhisa Kanahara, Shigenori Tadokoro대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2017 · 제15권 제1호Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case ReportHideaki Shimizu, Jun-ichi Iga, Saori Inoue, Shinichiro Ochi, Shu-ichi Ueno, Yuta Yoshino대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제4호Aripiprazole Long-acting Injectable Two-injection Start to Manage Supersensitivity Psychosis: A Case ReportHazal Yavuzlar Civan대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2025 · 제23권 제4호Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two CasesAgostina Giardini, Domenico De Berardis, Federica Vellante, Felice Iasevoli, Gabriella Rapini, Ida De Lauretis, Laura Orsolini, Luigi Olivieri, Marco Alessandrini, Massimo Di Giannantonio, Michele Fornaro, Nicola Serroni, Paolo Cottura, Sabatino Trotta대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제1호Cariprazine — an Alternative Treatment for Clozapine-resistant Schizophrenia?Adam Montgomery, Luiz Dratcu, Marianna Rogowska대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제1호Clinical Usefulness of Amisulpride Add-on Therapy in Schizophrenia Patients without Treatment Response to Second-generation Antipsychotics조서은, 조성진, Chi Un Pae, Kyoung-Sae Na, Seung-Gul Kang대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제1호

이 간행물의 다른 논문 (20건)