Ultradian Rest-activity Rhythms Induced by Quinpirole in Mice Using Wavelet Analysis
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective: Ultradian rhythms are biological rhythms with periods of a few seconds to a few hours. Along with circadian rhythms, ultradian rhythms influence human physiology. However, such rhythms have not been studied as intensively as circadian rhythms. This study aimed to identify ultradian rest-activity rhythms induced by the dopamine D2/D3 agonist quinpirole in mice. Methods: We used 10 mice from the Institute of Cancer Research. Quinpirole was administered at a dose of 0.5 mg/kg. We assessed free rest-activity using infrared detectors and conducted wavelet analysis to measure the period and its variation. We also used the paired t test to compare ultradian rhythm patterns. Results: Quinpirole did not significantly change total 24-hour locomotor activity (p = 0.065). However, it significantly increased locomotor activity during the dark phase (p = 0.001) and decreased it during the light phase (p = 0.016). In the continuous wavelet transform analysis, the mean period was 5.618 hours before quinpirole injection and 4.523 hours after injection. The period showed a significant decrease (p = 0.040), while the variation remained relatively consistent before and after quinpirole injection. Conclusion: This study demonstrated ultradian rest-activity rhythms induced by quinpirole using wavelet analysis. Quinpirole-induced ultradian rhythms exhibited rapid oscillations with shortened periods and increased activity during the dark phase. To better understand these changes in ultradian rhythms caused by quinpirole, it is essential to compare them with the effects of other psychopharmacological agents. Furthermore, investigating the pharmacological impact on ultradian rest-activity rhythms may have valuable applications in clinical studies.
Abstract
Objective: Ultradian rhythms are biological rhythms with periods of a few seconds to a few hours. Along with circadian rhythms, ultradian rhythms influence human physiology. However, such rhythms have not been studied as intensively as circadian rhythms. This study aimed to identify ultradian rest-activity rhythms induced by the dopamine D2/D3 agonist quinpirole in mice. Methods: We used 10 mice from the Institute of Cancer Research. Quinpirole was administered at a dose of 0.5 mg/kg. We assessed free rest-activity using infrared detectors and conducted wavelet analysis to measure the period and its variation. We also used the paired t test to compare ultradian rhythm patterns. Results: Quinpirole did not significantly change total 24-hour locomotor activity (p = 0.065). However, it significantly increased locomotor activity during the dark phase (p = 0.001) and decreased it during the light phase (p = 0.016). In the continuous wavelet transform analysis, the mean period was 5.618 hours before quinpirole injection and 4.523 hours after injection. The period showed a significant decrease (p = 0.040), while the variation remained relatively consistent before and after quinpirole injection. Conclusion: This study demonstrated ultradian rest-activity rhythms induced by quinpirole using wavelet analysis. Quinpirole-induced ultradian rhythms exhibited rapid oscillations with shortened periods and increased activity during the dark phase. To better understand these changes in ultradian rhythms caused by quinpirole, it is essential to compare them with the effects of other psychopharmacological agents. Furthermore, investigating the pharmacological impact on ultradian rest-activity rhythms may have valuable applications in clinical studies.
참고문헌 (29)
- Kleitman N, "Biological rhythms and cycles", Physiol Rev, 29, pp.1~30 (1949)
- Asher G, "Beyond circadian rhythms : emerging roles of ultradian rhythms in control of liver functions", Hepatology, 77, pp.1022~1035 (2023)
- Fishbein AB, "Circadian disruption and human health", J Clin Invest, 131, pp.e148286~ (2021)
- Jagannath A, "The genetics of circadian rhythms, sleep and health", Hum Mol Genet, 26, pp.R128~R138 (2017)
- Walker WH 2nd, "Circadian rhythm disruption and mental health", Transl Psychiatry, 10, pp.28~ (2020)
- Ruan W, "Circadian rhythm as a therapeutic target", Nat Rev Drug Discov, 20, pp.287~307 (2021)
- Dong D, "Circadian rhythm in pharmacokinetics and its relevance to chronotherapy", Biochem Pharmacol, 178, pp.114045~ (2020)
- Closa D, "Short-term oscillations of aortic core temperature and thermogenic organ blood flow in the rat", Exp Physiol, 78, pp.243~253 (1993)
- Diatroptov ME, "Ultradian rhythms of body temperatures in male Wistar rats maintained under conditions of constant illumination", Bull Exp Biol Med, 167, pp.735~739 (2019)
- Stroh T, "Subcellular dynamics of somatostatin receptor subtype 1 in the rat arcuate nucleus : receptor localization and synaptic connectivity vary in parallel with the ultradian rhythm of growth hormone secretion", J Neurosci, 2, pp.8198~8205 (2009)
- Dowse H, "Ultradian components in the locomotor activity rhythms of the genetically normal mouse, Mus musculus", J Exp Biol, 213(Pt 10), pp.1788~1795 (2010)
- Beukeboom R, "Activity vs exploration : locomotion in a known and unknown environment differs in Atlantic cod juveniles(Gadus morhua)", Behav Processes, 202, pp.104736~ (2022)
- Van Hartesveldt C, "Effects of intracerebral quinpirole on locomotion in rats", Eur J Pharmacol, 214, pp.27~32 (1992)
- Park J, "Prediction of locomotor activity by infrared motion detector on sleep-wake state in mice", Clin Psychopharmacol Neurosci, 19, pp.303~312 (2021)
- Blum ID, "A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal", Elife, 3, pp.e05105~ (2014)
- Lee JH, "Optimization of analysis of circadian rest-activity rhythm using cosinor analysis in mice", Psychiatry Investig, 19, pp.380~385 (2022)
- Lee JH, "Analysis of ultradian rest-activity rhythms using locomotor activity in mice", Kosin Med J, 37, pp.127~133 (2022)
- Leise TL, "Wavelet-based time series analysis of circadian rhythms", J Biol Rhythms, 26, pp.454~463 (2011)
- Leise TL, "Wavelet analysis of circadian and ultradian behavioral rhythms", J Circadian Rhythms, 11, pp.5~ (2013)
- Leise TL, "Wavelet-based analysis of circadian behavioral rhythms", Methods Enzymol, 551, pp.95~119 (2015)
- Cheon Y, "Can residual symptoms during inter-episode period after partial remission in bipolar I disorder have cyclic patterns with specific frequencies?", Psychiatry Investig, 15, pp.330~334 (2018)
- Bourguignon C, "Control of rest : activity by a dopaminergic ultradian oscillator and the circadian clock", Front Neurol, 8, pp.614~ (2017)
- Park J, "Changes of locomotor activity by dopamine D2, D3 agonist quinpirole in mice using home-cage monitoring system", Clin Psychopharmacol Neurosci, 21, pp.686~692 (2023)
- Park J, "Influences of dopamine D2, D3 agonist quinpirole dosage on locomotor activity measured by open-field test", Mood Emot, 20, pp.59~64 (2022)
- Hong YR, "Machine learning algorithms for the prediction of locomotor activity by an infrared motion detector on the sleep-wake states in mice", Clin Psychopharmacol Neurosci, 21, pp.279~287 (2023)
- Wirz-Justice A, "Disturbed circadian rest-activity cycles in schizophrenia patients : an effect of drugs?", Schizophr Bull, 27, pp.497~502 (2001)
- Moon E, "Effects of antipsychotics on circadian rhythms in humans : a systematic review and meta-analysis", Prog Neuropsychopharmacol Biol Psychiatry, 108, pp.110162~ (2021)
- Eilam D, "Biphasic effect of D-2 agonist quinpirole on locomotion and movements", Eur J Pharmacol, 161, pp.151~157 (1989)
- Solanto MV, "Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder : a review and integration", Behav Brain Res, 94, pp.127~152 (1998)