Changes of Locomotor Activity by Dopamine D2, D3 Agonist Quinpirole in Mice Using Home-cage Monitoring System
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Objective: As dopamine is closely linked to locomotor activities, animal studies on locomotor activities using dopaminergic agents were widely done. However, most of animal studies were performed for a short period that there is a lack of longitudinal study on the effects of dopaminergic agents on locomotor activities. This study aimed to examine the longterm effect of a dopamine D2, D3 agonist quinpirole on locomotor activities in mice using a home-cage monitoring system. Methods: The locomotor activities of Institute Cancer Research mice were measured by infrared motion detectors in home-cages under the 12-hour dark and 12-hour light condition for three days after the quinpirole injection. Quinpirole was injected at a concentration of 0.5 mg/kg intraperitoneally in the beginning of the dark phase. The locomotor activities before and after the quinpirole administration were compared by the Wilcoxon signed-rank test and one-way repeated measures ANOVA. Results: After the quinpirole administration, the 24-hour total locomotor activity did not change (p = 0.169), but activities were significantly increased in the 12-hour dark phase sum (p = 0.013) and decreased in the 12-hour light phase sum (p = 0.009). Significant increases in the activities were observed in the dark-light difference (p = 0.005) and dark-light ratio (p = 0.005) as well. Conclusion: This study suggests that quinpirole injection entrains the circadian rest-activity rhythm of locomotor activities. Therefore, quinpirole can be a drug that mediates locomotor activity as a dopamine agonist as well as a modulator of the circadian rhythms.
Abstract
Objective: As dopamine is closely linked to locomotor activities, animal studies on locomotor activities using dopaminergic agents were widely done. However, most of animal studies were performed for a short period that there is a lack of longitudinal study on the effects of dopaminergic agents on locomotor activities. This study aimed to examine the longterm effect of a dopamine D2, D3 agonist quinpirole on locomotor activities in mice using a home-cage monitoring system. Methods: The locomotor activities of Institute Cancer Research mice were measured by infrared motion detectors in home-cages under the 12-hour dark and 12-hour light condition for three days after the quinpirole injection. Quinpirole was injected at a concentration of 0.5 mg/kg intraperitoneally in the beginning of the dark phase. The locomotor activities before and after the quinpirole administration were compared by the Wilcoxon signed-rank test and one-way repeated measures ANOVA. Results: After the quinpirole administration, the 24-hour total locomotor activity did not change (p = 0.169), but activities were significantly increased in the 12-hour dark phase sum (p = 0.013) and decreased in the 12-hour light phase sum (p = 0.009). Significant increases in the activities were observed in the dark-light difference (p = 0.005) and dark-light ratio (p = 0.005) as well. Conclusion: This study suggests that quinpirole injection entrains the circadian rest-activity rhythm of locomotor activities. Therefore, quinpirole can be a drug that mediates locomotor activity as a dopamine agonist as well as a modulator of the circadian rhythms.
참고문헌 (31)
- Vivek Verma, "Classic Studies on the Interaction of Cocaine and the Dopamine Transporter", Clinical Psychopharmacology and Neuroscience, 13(3), pp.227~238 (2015), 대한정신약물학회
- Kayo Akiyama, "Music Enhances Drunkenness: A Phenomenon Related to Increased Dopaminergic Function", Clinical Psychopharmacology and Neuroscience, 8(3), pp.156~159 (2010), 대한정신약물학회
- Victoria S. Dalton, "Rapid Changes in D1 and D2 Dopamine Receptor Binding in Striatal Subregions after a Single Dose of Phencyclidine", Clinical Psychopharmacology and Neuroscience, 9(2), pp.67~72 (2011), 대한정신약물학회
- Kelly MA, "Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations", J Neurosci, 18, pp.3470~3479 (1998)
- Giros B, "Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter", Nature, 379, pp.606~612 (1996)
- Kobayashi K, "Dopamine deficiency in mice", Brain Dev, 22(Suppl 1), pp.S54~S60 (2000)
- Chang CK, "Inhibition of the dopamine system in rat amygdala attenuates the picrotoxin-induced locomoter hyperactivity and hypertension", Clin Exp Pharmacol Physiol, 31, pp.284~288 (2004)
- Missale C, "Dopamine receptors : From structure to function", Physiol Rev, 78, pp.189~225 (1998)
- Beaulieu JM, "The physiology, signaling, and pharmacology of dopamine receptors", Pharmacol Rev, 63, pp.182~217 (2011)
- Stuchlik A, "Manipulation of D2 receptors with quinpirole and sulpiride affects locomotor activity before spatial behavior of rats in an active place avoidance task", Neurosci Res, 58, pp.133~139 (2007)
- Van Hartesveldt C, "Effects of intracerebral quinpirole on locomotion in rats", Eur J Pharmacol, 214, pp.27~32 (1992)
- Mattingly BA, "Effects of daily SKF 38393, quinpirole, and SCH 23390 treatments on locomotor activity and subsequent sensitivity to apomorphine", Psychopharmacology(Berl), 110, pp.320~326 (1993)
- McDougall SA, "MK801-induced locomotor activity in preweanling and adolescent male and female rats: Role of the dopamine and serotonin systems", Psychopharmacology(Berl), 237, pp.2469~2483 (2020)
- Himanshu, "A Review of Behavioral Tests to Evaluate Different Types of Anxiety and Anti-anxiety Effects", Clinical Psychopharmacology and Neuroscience, 18(3), pp.341~351 (2020), 대한정신약물학회[DOI]
- Shieh KR, "Formosan wood mice(Apodemus semotus)exhibit more exploratory behaviors and central dopaminergic activities than C57BL", 6 mice in the open field test, 2020, pp.63, 27~34
- Blum ID, "A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal", Elife, 3, pp.e05105~ (2014)
- Bourguignon C, "Control of rest : Activity by a dopaminergic ultradian oscillator and the circadian clock", Front Neurol, 8, pp.614~ (2017)
- Iannello F, "Non-intrusive high throughput automated data collection from the home cage", Heliyon, 5, pp.e01454~ (2019)
- Jeonghyun Park, "Prediction of Locomotor Activity by Infrared Motion Detector on Sleep-wake State in Mice", Clinical Psychopharmacology and Neuroscience, 19(2), pp.303~312 (2021), 대한정신약물학회[DOI]
- Yoo Rha Hong, "Machine Learning Algorithms for the Prediction of Locomotor Activity by an Infrared Motion Detector on the Sleep-wake States in Mice", Clinical Psychopharmacology and Neuroscience, 21(2), pp.279~287 (2023), 대한정신약물학회[DOI]
- Klein CJMI, "Measuring locomotor activity and behavioral aspects of rodents living in the home-cage", Front Behav Neurosci, 16, pp.877323~ (2022)
- Nakajima R, "Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice", Neuropsychopharmacol Rep, 39, pp.223~237 (2019)
- Nakajima R, "Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice", Neuropsychopharmacol Rep, 41, pp.111~116 (2021)
- Eilam D, "The ontogeny of exploratory behavior in the house rat(Rattus rattus) : The mobility gradient", Dev Psychobiol, 21, pp.679~710 (1988)
- Eilam D, "Biphasic effect of D-2 agonist quinpirole on locomotion and movements", Eur J Pharmacol, 161, pp.151~157 (1989)
- Van Hartesveldt C, "Ontogeny of biphasic locomotor effects of quinpirole", Pharmacol Biochem Behav, 48, pp.781~786 (1994)
- Akhisaroglu M, "Diurnal rhythms in quinpirole-induced locomotor behaviors and striatal D2", D3 receptor levels in mice, 2005, pp.80, 371~377
- Whitaker NG, "Disposition and biotransformation of quinpirole, a new D-2 dopamine agonist antihypertensive agent, in mice, rats, dogs, and monkeys", Drug Metab Dispos, 15, pp.107~113 (1987)
- 김정아, "Implications of Circadian Rhythm in Dopamine and Mood Regulation", Molecules and Cells, 40(7), pp.450~456 (2017), 한국분자세포생물학회
- Gaytan O, "Diurnal differences in sensitization to methylphenidate", Brain Res, 864, pp.24~39 (2000)
- Amato D, "Compulsive-like effects of quinpirole on drinking behavior in rats are inhibited by substituting ethanol for water", Behav Brain Res, 177, pp.340~346 (2007)