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Higher Levels of Galectin-1 and Galectin-3 in Young Subjects with Autism Spectrum Disorder Compared to Unaffected Siblings and Healthy Controls

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Objective: Despite being highly genetic, the etiology of autism spectrum disorder (ASD), has not yet been clarified. Recent research has focused on the role of neuroinflammation and immune system dysfunction in the pathophysiology of neurodevelopmental disorders including ASD. Galectin-1 and galactin-3 are considered among the biomarkers of neuroinflammation and there has been recent reports on the potential role of galectins in the etiology of neurodevelopmental disorders. However, there has been no study examining the relationship between ASD and galectin levels. Methods: Current study aimed to investigate galectin-1 and galectin-3 serum levels in young subjects with ASD comparing with their unaffected siblings and healthy controls. Results: We found significantly higher levels of galectin-1 in case group compared to both unaffected siblings and healthy controls, and higher levels of galectin-3 in case group compared to healthy controls. However, there was no significant association between galectin-1 and galectin-3 levels with the severity of ASD. Conclusion: Findings of our study may support neuroinflammation hypothesis in the etiology of ASD and the potential role of galectin-1 and galectin-3 as biomarkers.

Abstract

Objective: Despite being highly genetic, the etiology of autism spectrum disorder (ASD), has not yet been clarified. Recent research has focused on the role of neuroinflammation and immune system dysfunction in the pathophysiology of neurodevelopmental disorders including ASD. Galectin-1 and galactin-3 are considered among the biomarkers of neuroinflammation and there has been recent reports on the potential role of galectins in the etiology of neurodevelopmental disorders. However, there has been no study examining the relationship between ASD and galectin levels. Methods: Current study aimed to investigate galectin-1 and galectin-3 serum levels in young subjects with ASD comparing with their unaffected siblings and healthy controls. Results: We found significantly higher levels of galectin-1 in case group compared to both unaffected siblings and healthy controls, and higher levels of galectin-3 in case group compared to healthy controls. However, there was no significant association between galectin-1 and galectin-3 levels with the severity of ASD. Conclusion: Findings of our study may support neuroinflammation hypothesis in the etiology of ASD and the potential role of galectin-1 and galectin-3 as biomarkers.

참고문헌 (54)

  1. American Psychiatric Association, "Diagnostic and statistical manual of mental disorders (DSM-5-TR)" (2013), American Psychiatric Association Publishing
  2. Centers for Disease Control and Prevention, "Prevalence of autism spectrum disorders — autism and developmental disabilities monitoring network, 14 sites, United States, 2008", MMWR Surveill Summ, 61, pp.1~19 (2012)
  3. Pendergrass S, "Uncovering the etiology of autism spectrum disorders: Genomics, bioinformatics, environment, data collection and exploration, and future possibilities", Pac Symp Biocomput, pp.422~426 (2014)
  4. Eissa N, "Role of neuroinflammation in autism spectrum disorder and the emergence of brain histaminergic system. Lessons also for BPSD?", Front Pharmacol, 11, pp.886~ (2020)
  5. Vargas DL, "Neuroglial activation and neuroinflammation in the brain of patients with autism", Ann Neurol, 57, pp.67~81 (2005)
  6. Suzuki K, "Microglial activation in young adults with autism spectrum disorder", JAMA Psychiatry, 70, pp.49~58 (2013)
  7. Morgan JT, "Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism", Biol Psychiatry, 68, pp.368~376 (2010)
  8. Tetreault NA, "Microglia in the cerebral cortex in autism", J Autism Dev Disord, 42, pp.2569~2584 (2012)
  9. Garbett K, "Immune transcriptome alterations in the temporal cortex of subjects with autism", Neurobiol Dis, 30, pp.303~311 (2008)
  10. Chez MG, "Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children", Pediatr Neurol, 36, pp.361~365 (2007)
  11. Chez MG, "Immune therapy in autism : Historical experience and future directions with immunomodulatory therapy", Neurotherapeutics, 7, pp.293~301 (2010)
  12. Albenzio M, "Milk nutrition and childhood epilepsy : an ex vivo study on cytokines and oxidative stress in response to milk protein fractions", J Dairy Sci, 101, pp.4842~4852 (2018)
  13. Monji A, "Cytokines and schizophrenia : microglia hypothesis of schizophrenia", Psychiatry Clin Neurosci, 63, pp.257~265 (2009)
  14. Takano T, "Role of microglia in autism : Recent advances", Dev Neurosci, 37, pp.195~202 (2015)
  15. Colonna M, "Microglia function in the central nervous system during health and neurodegeneration", Annu Rev Immunol, 35, pp.441~468 (2017)
  16. Xu N, "Inflammatory cytokines : Potential biomarkers of immunologic dysfunction in autism spectrum disorders", Mediators Inflamm, 2015, pp.531518~ (2015)
  17. Ashwood P, "Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome", Brain Behav Immun, 25, pp.40~45 (2011)
  18. Klin A, "Biomarkers in autism spectrum disorder: Challenges, advances, and the need for biomarkers of relevance to public health", Focus(Am Psychiatr Publ), 16, pp.135~142 (2018)
  19. Shen L, "Biomarkers in autism spectrum disorders : Current progress", Clin Chim Acta, 502, pp.41~54 (2020)
  20. Semih Erden, "Investigation of Relaxin-3 Serum Levels in terms of Social Interaction, Communication, and Appetite as a Biomarker in Children with Autism", Clinical Psychopharmacology and Neuroscience, 20(1), pp.135~142 (2022), 대한정신약물학회[DOI]
  21. Barondes SH, "Galectins. Structure and function of a large family of animal lectins", J Biol Chem, 269, pp.20807~20810 (1994)
  22. Chen HL, "Glycobiology of the nervous system", pp.517~542 (2014), Springer
  23. Elola MT, "Galectins : Matricellular glycan-binding proteins linking cell adhesion, migration, and survival", Cell Mol Life Sci, 64, pp.1679~1700 (2007)
  24. Shin T, "The pleiotropic effects of galectin-3 in neuroinflammation : A review", Acta Histochem, 115, pp.407~411 (2013)
  25. Starossom SC, "Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration", Immunity, 37, pp.249~263 (2012)
  26. McGraw J, "Regulation of neuronal and glial galectin-1expression by peripheral and central axotomy of rat primary afferent neurons", Exp Neurol, 195, pp.103~114 (2005)
  27. Wada M, "Decreased galectin-1 immunoreactivity of the skin in amyotrophic lateral sclerosis", J Neurol Sci, 208, pp.67~70 (2003)
  28. Dumic J, "Galectin-3 : An open-ended story", Biochim Biophys Acta, 1760, pp.616~635 (2006)
  29. Sciacchitano S, "Galectin-3 : One molecule for an alphabet of diseases, from A to Z", Int J Mol Sci, 19, pp.379~ (2018)
  30. Lalancette-Hébert M, "Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury", J Neurosci, 32, pp.10383~10395 (2012)
  31. Rahimian R, "Galectin-3 : Mediator of microglia responses in injured brain", Drug Discov Today, 23, pp.375~381 (2018)
  32. Caniglia JL, "Immunopathology of galectin-3 : An increasingly promising target in COVID-19", F1000Res, 9, pp.1078~ (2020)
  33. Ünal F, "Reliability and validity of the schedule for affective disorders and schizophrenia for school-age children-present and lifetime version, DSM-5November 2016-Turkish adaptation (K-SADS-PL-DSM-5-T)", Turk Psikiyatri Derg, 30, pp.42~50 (2019)
  34. İncekaş Gassaloğlu S, "Validity and reliability analysis of Turkish version of childhood autism rating scale", Turk Psikiyatri Derg, 27, pp.266~274 (2016)
  35. Kaufman J, "K-SADSPL", J Am Acad Child Adolesc Psychiatry, 39, pp.1208~ (2000)
  36. Kaufman J, "K-SADS-PL DSM-5: November 2016", Yale University, ~ (2016)
  37. Schopler E, "Toward objective classification of childhood autism : Childhood autism rating scale(CARS)", J Autism Dev Disord, 10, pp.91~103 (1980)
  38. Kajitani K, "Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation", Psychopharmacology(Berl), 234, pp.2919~2927 (2017)
  39. Borovcanin MM, "IL-33", ST2 pathway and galectin-3as a new analytes in pathogenesis and cardiometabolic risk evaluation in psychosis, 2018, pp.9, 271~
  40. Yüksel RN, "Galectin-1 and galectin-3 levels in patients with schizophrenia and their unaffected siblings", Psychiatr Q, 91, pp.715~725 (2020)
  41. King DR, "Relationship between novel inflammatory biomarker galectin-3 and depression symptom severity in a large community-based sample", J Affect Disord, 281, pp.384~389 (2021)
  42. Wu L, "A novel function of microRNA let-7d in regulation of galectin-3 expression in attention deficit hyperactivity disorder rat brain", Brain Pathol, 20, pp.1042~1054 (2010)
  43. Wu LH, "Circulating microRNA let-7d in attention-deficit", hyperactivity disorder, 2015, pp.17, 137~146
  44. Ümit Is¸ ık, "Serum Galectin-3 Levels in Children with Attention-Deficit", Hyperactivity Disorder, 2020, pp.17(3), 256~261[DOI]
  45. Lucchina L, "Altered peripheral and central inflammatory responses in a mouse model of autism", Autism Res, 7, pp.273~289 (2014)
  46. Calcia MA, "Stress and neuroinflammation: A systematic review of the effects of stress on microglia and the implications for mental illness", Psychopharmacology(Berl), 233, pp.1637~1650 (2016)
  47. Salatino M, "Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer", Expert Opin Biol Ther, 8, pp.45~57 (2008)
  48. Kajitani K, "Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus", Cell Death Differ, 16, pp.417~427 (2009)
  49. Iwamoto M, "The Galectin-1 level in serum as a novel marker for stress", Glycoconj J, 27, pp.419~425 (2010)
  50. Jiang HR, "Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis", J Immunol, 182, pp.1167~1173 (2009)
  51. Chen SS, "Downregulating galectin-3 inhibits proinflammatory cytokine production by human monocyte-derived dendritic cells via RNA interference", Cell Immunol, 294, pp.44~53 (2015)
  52. Desmedt V, "Galectin-3 in renal pathology : More than just an innocent bystander", Am J Nephrol, 43, pp.305~317 (2016)
  53. Ouyang J, "Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma", Blood, 121, pp.3431~3433 (2013)
  54. Saresella M, "An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children", Biol Psychiatry, 66, pp.978~984 (2009)

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